Jeff Saucerman
@jsauce7.bsky.social
Professor of Biomedical Engineering and Cardiovascular Medicine at UVA. Systems biology to discover drugs for heart disease. Hiking with my dog in Shenandoah NP, around Charlottesville. https://engineering.virginia.edu/faculty/jeffrey-saucerman
My painting of some fun math that we found to be key in cardiac development. We showed that the abrupt switch from mesoderm to cardiac progenitor is driven by a pair of saddle node bifurcations. #sciart
Happy New Year! Just 5 days until the 4th Netflux and Network Biology Virtual Conference on Jan 7, 1-5 pm ET. Please share. Agenda and free registration at: tinyurl.com/netfluxnet2026
Accepted ms on modeling human atrial disease posted @dev-journal.bsky.social just now. Congratulations to @irfankathiriya.bsky.social @jsauce7.bsky.social and team! @gladstoneinst.bsky.social @ucsfanesthesia.bsky.social journals.biologists.com/dev/article-...
Reduced TBX5 dosage undermines developmental control of atrial cardiomyocyte identity in a model of human atrial disease
While atrial septal defects (ASDs) and atrial fibrillation (AF) present differently, there is evidence that they share some genetic basis. Here, we used directed differentiation of human induced pluri...
journals.biologists.com
Always fun collaborating on networks of cardiac development with Irfan, @benoitbruneau.bsky.social, and team!
Benoit Bruneau@benoitbruneau.bsky.social · 8mo agogood new this morning: manuscript accepted! Final form of this pubmed.ncbi.nlm.nih.gov/40894762/ coming soon to @dev-journal.bsky.social. Congratulations to everyone from @ucsanfrancisco.bsky.social @ucsfanesthesia.bsky.social @gladstoneinst.bsky.social, and Alex Clark in @jsauce7.bsky.social's lab.
The 4th Netflux and Network Biology Virtual Conference is coming, Jan 7! Talks on network modeling across methods and biological systems. Free! tinyurl.com/netfluxnet2026
Announcing the 4th Netflux and Network Biology Virtual Conference, Jan 7! Free registration and abstract submission (Dec 12). Live demo of the new user-friendly Netflux webapp, student talks, keynote by Suzanne Gaudet (Novartis): bit.ly/4i1eQD6
Sauce lab dressed for Halloween as favorite proteins! 🎃👻🕷️. I was a serotonin receptor bound to LexaPro for Taylors recent paper.
How do signaling pathways differentially control cell size vs. shape? In a new preprint led by Alice Luanpaisanon, we iterate between experimental and computational methods to discover such pathways. 1/ www.biorxiv.org/content/10.1...
Paradoxically, heart failure involves both cell death and growth. How does a cell decide? In a paper at JMCC Plus led by Bryan Chun and Lavie Ngo, we find that rather than dying following hypertrophy, stressed cardiomyocytes commit early to either grow or die. www.sciencedirect.com/science/arti...
@j-muncie-vasic.bsky.social and @benoitbruneau.bsky.social show that MEF2C is not a one trick pony- it distinctly regulates different regions of heart tube formation. Glad @aclark.bsky.social and I could contribute gene regulatory networks that predict mechanisms.
Jon Muncie-Vasic@j-muncie-vasic.bsky.social · 11mo agoExcited to share that our manuscript “MEF2C controls segment-specific gene regulatory networks that direct heart tube morphogenesis” is now online @genesdev.bsky.social ! genesdev.cshlp.org/content/earl... (1/n)
Happy to share our latest preprint, "Network Modeling Predicts How DYRK1A Inhibition Promotes Cardiomyocyte Cycling after Ischemic/Reperfusion Injury", in collaboration with Matthew Wolf's lab, led by Bryce Murillo and Alex Young! www.biorxiv.org/content/10.1...
Do large language models understand how cells work? To find out, we built a pipeline that generates logic-based models of signaling networks using general purpose LLMs GPT, Gemini, or Claude. We benchmarked LLM-generated networks against 3 large-scale literature-curated and validated networks. 1/
On my way to AHA #BCVS25 in Baltimore! Come see Bryce Murillo present on a drug for DYRK1A that induces cardiomyocyte cell cycling in network models, isolated cardiomyocytes, and after myocardial infarction. Wed 9:39 am.
A few pics from my trip to Egypt. Cairo, Luxor, Alexandria
"The Faculty Senate expresses no confidence in the Board of Visitors for not protecting the University and its president from outside interference, ..." www.forbes.com/sites/michae...
University Of Virginia Faculty Vote No Confidence In Governing Board
The University of Virginia Faculty Senate has voted it has no confidence in the school’s Board of Visitors by a margin of 46 to 6, with 8 senators abstaining.
forbes.com
Public comment on this new "no animal only studies" is open here: www.fda.gov/news-events/... It closes next Monday.
FDA-NIH Workshop: Reducing Animal Testing
The FDA is hosting a workshop on reducing animal testing. The workshop is open to current FDA and NIH employees.
fda.gov
Eliza Bliss-Moreau@eblissmoreau.bsky.social · last yr.The line between “no Medicaid for you” and “the only option for access to ‘health care’ if you don’t have insurance is participating in risky, untested interventions” is a short one. Animal models are the bridge from bench to bedside.
On June 17, 2012, following the unjustified forced resignation of an effective university president, the University of Virginia’s Faculty Senate voted 68 to 2 to demand her reinstatement. Nine days later, the president was reinstated. Today the Faculty Senate votes on the same issue again.
