Benoit Bruneau
@benoitbruneau.bsky.social
Cardiac developmental biologist. Oakland and San Francisco. Hi friends! 🇨🇦
really important article. Are we feeding our discoveries (unpublished) to AI companies? Featuring our @gladstoneinst.bsky.social colleague Seth Shipman.
Carl Zimmer@carlzimmer.com · yesterdayFour days ago, a scientist was surprised by the news that Anthropic discovered new virus genes for making DNA. He says he’s been studying them for years—and feeding his data to Anthropic’s AI as part of his own research. Coincidence? Here’s my story. nyti.ms/3VSWayc
Putting the Fabulous back into Astrophysics!! (And did not break any bones!) bookshop.org/p/books/invi...
You take our bike lanes, we take the road. Toronto showed up Friday night. 📸 @geoffreybercarich via Instagram
Visually, it looks like they're just =disapparating=. Beam me up, Mr. Bug. They have a sort of hidden spring under their bellies, called a 'furca' or 'furcula'. Like having a secret catapult hidden down your trousers. I love the lowering of the antennae just before launch. 💨
All old dudes at Sugar concert at the Warfield in San Francisco
California DMV Adds Highway Chase To Road Test https://theonion.com/california-dmv-adds-highway-chase-to-road-test/
Big congrats to our postdoc Marycruz Flores Flores @mary-flores.bsky.social on receiving our campus' 2026 Graduate School Dean’s Postdoctoral Service Award @cuanschutz.bsky.social! @cupediatrics.bsky.social @cudevbio.bsky.social #zebrafish #devbio
Thrilled to see this published today! Truly special because we made the initial discovery >15 yrs ago! We found two copies of a human gene called BC200 embedded in a human poxvirus. BC200 blurs the line between gene & transposon—both functional & mutagenic! www.science.org/doi/10.1126/... 🧵1/n
Escape of the BC200 gene to a human poxvirus reveals its persistent transposition in primates
Transposable elements mobilize within and occasionally between genomes, including from host to virus. We identified two insertions of the human BC200 noncoding RNA gene in the poxvirus molluscum conta...
science.org
Odd playing posture for the Lincoln Jazz Center ensemble. Wynton Marsalis in the back
Out now in Science: Two papers from our lab reveal VIPR, an RNA-guided DNA-targeting system in bacteriophages, providing clues to the origins of CRISPR www.science.org/doi/10.1126/... www.science.org/doi/10.1126/... Congrats to Peter Yoon, @kenjmloi.bsky.social @terryzzy.bsky.social, T.Docter & team
A noncontiguous code for RNA-guided DNA recognition at the origin of CRISPR-Cas
CRISPR-Cas provides RNA-mediated adaptive immunity, but how its first RNA-guided effector arose is unclear. In this study, we report the discovery of Viral Interference Programmable Repeat (VIPR) syst...
science.org
A new discovery reveals how a SARS-CoV-2 protein reprograms immune cells to accelerate viral spread—and points to a new strategy for therapeutic intervention.
How a Single Viral Protein Hijacks Immune Cells to Supercharge COVID-19 Infection
A new discovery reveals how a SARS-CoV-2 protein reprograms immune cells to accelerate viral spread--and points to a new strategy for therapeutic intervention.
gladstone.org
1\ We know a bit about how 3D chromatin interactions are formed, but what do we know about how they are disrupted? We asked this question in our latest preprint: doi.org/10.64898/202..., focusing on the massive loss of promoter interactions during neuronal differentiation.
Developmentally programmed loss of long-range Polycomb interactions is regulated by cohesin
Distal regulatory elements (DREs), such as enhancers, can regulate genes across megabase-long distances, presumably via coming into close spatial proximity. The establishment of new transcriptional programmes during cell type transitions is associated with widespread rewiring of the spatial organisation of the genome, including gain and loss of chromatin interactions. Extensive effort has been invested into understanding how chromatin interactions are formed during development, yet the mechanisms underlying their developmental loss remain largely unclear. By leveraging chromatin accessibility-assisted footprinting, acute protein degradation and chromatin conformation capture, we show that loss of promoter interactions cannot be explained by reduced binding of sequence-specific transcription factors (TFs). Instead, we identify a subset of interactions that depend on cohesin for programmed developmental disruption. These sites are characterized by high Polycomb enrichment and TF occupancy and engage in strong long-range interactions that undergo extensive differentiation-dependent rewiring. Preventing interaction loss by acute cohesin degradation results in the preferential downregulation of associated genes. Together, these results suggest that cohesin indirectly regulates developmental loss of Polycomb interactions by enabling the acquisition of other potentially regulatory contacts in a process that may shape transcriptional programs during cell type transitions. ### Competing Interest Statement The authors have declared no competing interest. European Research Council Helmholtz Society, VH-NG-1604
doi.org
STAT's cancer reporter @angusrohan.bsky.social explains why the recently approved pancreatic cancer drug is 'basically' the biggest advancement for patients in half a century.
man that rocks! The two guitar attack is so cool and they really match in the spectacular last third
Punk Rock History@punkrockhistory.bsky.social · 2w agokick out the jams motherf⭐ckers In memory of MC5’s charismatic lead singer Rob Tyner, who passed away 35 years ago today MC5 – Kick Out The Jams – Live at Tartar Field, 1970 #punkrock #protopunk #waynekramer #MC5 #history #punkrockhistory #otd
My grandfather, who is 102 and a medical doctor, has told me about the times before polio was cured. Most years, upon returning to school after summer’s break, there would be some children would didn’t make it back to school because of polio.
Kathleen Bachynski@bachynski.bsky.social · 2w ago“On Thursday, Mr. Gorton said that “the success of the polio vaccine was a massive medical fraud” and that widespread vaccination was a “public health disaster.” He received a standing ovation… Mr. Kennedy spoke next, linking arms with the group even as measles cases continue to rise”
I am not often truly angry but this is one has tested my limits
Kathleen Bachynski@bachynski.bsky.social · 2w ago“On Thursday, Mr. Gorton said that “the success of the polio vaccine was a massive medical fraud” and that widespread vaccination was a “public health disaster.” He received a standing ovation… Mr. Kennedy spoke next, linking arms with the group even as measles cases continue to rise”
Transformative opportunity for early career faculty @hhmi-science.bsky.social #FreemanHrabowski Scholars competition opens 11/3/2026 but you can get started NOW: view application components, establish eligibility, and unlock example applications and other resources www.hhmi.org/programs/fre...
Early Career Faculty Program | Freeman Hrabowski Scholars | HHMI
The Freeman Hrabowski Scholars Program offers comprehensive support to outstanding early career faculty committed to scientific excellence in their own research, and to fostering labs that expand the ...
hhmi.org
sad to learn that Terri Grodzicker has passed. She was the founding editor of @genesdev.bsky.social and instantly made it a phenomenally important journal. Over 35 years as editor she brought the most important science to an eager audience. It is rare to find someone with such a breadth of knowledge
Pathway to Independence – an interview with Maëlle Bellec In this interview, Maëlle talks about her work on translation dynamics in development, her hopes for the programme and her career journey from vineyard to microscope. doi.org/10.1242/dev....
“What if Frog is being chased by a big animal with many sharp teeth? What if he is being eaten up?” cried Toad.
Blood test shows promise in detecting pancreatic cancer early—a ‘holy grail’ for the field www.scientificamerican.com/article/bloo...
Blood test shows promise in detecting pancreatic cancer early—a ‘holy grail’ for the field
Pancreatic cancer is typically caught in its latest stages, when it is hardest to treat
scientificamerican.com
A welcome development for Canada 🇨🇦 www.nytimes.com/2026/09/16/w...
E.U. Talks of Making Canada First ‘Associate Member’ as U.S. Ties Weaken (Gift Article)
Canada and the European Union have been confronting an increasingly challenging relationship with the United States under President Trump.
nytimes.com
That's Billion with a B.. Last night actor Michael J. Fox accepted an Emmys for his contributions to Parkinson’s disease research. To date, his has helped raise 3 billion dollars for Parkinson’s research
