Yale Kavli Institute for Neuroscience

@kavliatyale.bsky.social

We aim to understand how genes, molecules, cells, and neural circuits interact to give rise to brain development and behavior, and to apply this knowledge to advance treatments for brain disorders. https://medicine.yale.edu/kavli/

Congratulations to Evelyn Jiang for receiving the 2026 Kavli Institute for Neuroscience Undergraduate Thesis Prize! In the Demb Lab, she investigated the molecular mechanisms underlying vision, focusing on the role of dynamin proteins in vesicle recycling at retinal synapses.👁️🧠

Quote from Evelyn Jiang: "I hope to continue pursuing ophthalmology research, particularly in clinical and translational settings. I spent this summer working in science outreach at the University of Guelph and will be attending medical school at the University of Toronto in the fall!“

Congratulations to Jack Cloherty for receiving the 2026 Kavli Institute for Neuroscience Undergraduate Thesis Prize! In the lab of Le Zhang, PhD, Jack was introduced to (and fascinated by) the biological mechanisms and immune interactions that underlie neurodegenerative diseases.

Quote from Jack Cloherty: "I'll be spending the next two years teaching high school science through Teach for America. I am endlessly glad for the people and ideas that Yale Neuroscience has introduced me to, and hope to return to neurodegenerative disease and immune interactions as a physician in the future."

Special congratulations to Yvonne Hsu, 1st author of the paper! Yvonne received a Kavli Postdoctoral Fellowship in 2021, focused on the development of the “little brain” of the heart, which kick-started this project. 🧠♥️🧪

Yale Neuroscience@yaleneuro.bsky.social · 3mo ago

A new @nature.com study from Rui Chang's lab uses lineage tracing, 3D imaging, single-cell transcriptomics, and genetic perturbations to show how organ-specific neural circuits are formed. They reveal that organs help shape their own nervous systems.

Complexity in the brain may begin with surprisingly simple patterns. In a new Yale study, physicist Christopher Lynn examined individual neurons and found that, despite their complexity, their behavior may follow simpler patterns than expected. Learn more: bit.ly/4dZvgeA

A digital illustration of a neural network, featuring an interconnected web of glowing neurons and synapses. The central neuron is prominent, with vibrant orange branches extending outward. Surrounding the neuron are translucent spheres connected by blue lines, representing a network.

Our new preprint is out! We examined the associations between multimodal brain measures (structure, microstructure, function) and psychopathology domains to predict adolescent functioning using the ABCD Study. In collab with @yiplab.bsky.social and co!

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 3mo ago

Distinct associations between multimodal brain measures and psychopathology domains predict adolescent functioning https://www.biorxiv.org/content/10.64898/2026.06.03.729937v1

(Re)discover the scientific journey of Rafael Perez, 2022-2023 Kavli Institute at Yale Postdoctoral Award for Academic Diversity awardee and newest recipient of the @kavlifoundation.org Scholar Program.

The Kavli Foundation@kavlifoundation.org · 4mo ago

Meet our newest #KavliScholar: Dr. Rafael E. Perez, Assoc. Research Scientist in the Dept. of Psychiatry and Neurology at Yale School of Medicine. Perez investigates how experience affects opioid analgesia, tolerance and addiction. Learn more: www.kavlifoundation.org/people/rafae... #KavliNeuro

When an animal moves, their neurons' axons have to stretch and bend. How do these axons keep their integrity? In a new study, @yaleneuro.bsky.social's Shaul Yogev 🥼 uncovers how mechanical forces trigger an axonal response that maintains axon integrity and microtubule continuity.

External mechanical force drives axonal cytoskeletal rearrangements

Axons experience strong mechanical forces due to animal movement. These forces serve as sensory cues in mechanosensory neurons, but their impact on ot…

sciencedirect.com

Often a brake, sometimes a gas pedal. The neurotransmitter GABA typically inhibits brain activity. But in a new study published in #Neuron, researchers in the @mhigley.bsky.social lab show that GABA may, in certain circumstances, enhance neuronal activity.

The Brain’s Braking System Can Sometimes Become a Gas Pedal, Study Finds

A neurotransmitter known to quiet activity in the brain can sometimes do the opposite, researchers find, offering implications for psychiatric treatment.

medicine.yale.edu

Spotlight on Yong-Hui Jiang, MD, PhD, Yale Genetics & @yaleneuro.bsky.social 🔦 His team is developing a genome-editing🧬platform that could implement targeted therapies for neurodevelopmental disorders directly in the brain🧠 Read the project & Jiang's journey!👇

Yong-Hui Jiang: Unlocking Genetic Mysteries to Treat Brain Disorders

Yong-Hui Jiang’s research has uncovered the biology of neurogenetic disorders like Angelman syndrome and autism. His genome-editing work could lead to targeted

medicine.yale.edu

In a @cp-cellstemcell.bsky.social study, researchers led by @yaleschoolofmed.bsky.social's In-Hyun Park 👨‍🔬 created pineal gland organoids 🧠 🧫 that release melatonin and are functional in vivo—offering a new way to study sleep dysfunction💤 in conditions like Angelman syndrome.

Meet Pineal Gland Organoids, a New Tool for Studying Sleep

Researchers have made miniature versions of the pineal gland. They’re helping explain the sleep challenges that come with conditions like Angelman syndrome and

medicine.yale.edu

A new study led by @yale.edu's Becca Levy & Martin Slade 🥼 found that nearly 50% of adults aged 65+ showed improvement in cognition, physical function, or both, over time and that these improvements were more likely among individuals with positive age beliefs! 🧠💪 More 👇

New study challenges notion that aging means decline, finds many older adults improve over time

Aging in later life is often portrayed as a steady slide toward physical and cognitive decline. But a new study by scientists at Yale University suggests an

ysph.yale.edu