Dear all, if you’re interested in DNA base excision repair, please see our new bioRxiv preprint at the link below, in which we reveal why POLB is required for rapid rates of BER in human cells, despite its catalytic redundancy several other DNA polymerases. www.biorxiv.org/cgi/content/...

DNA Polymerase beta Accelerates Cellular DNA Base Excision Repair by Suppressing Excessive PARP1 Engagement

DNA polymerase beta (POLB) is required for rapid rates of cellular DNA base excision repair (BER). However, the reason for this requirement is unclear, because other DNA polymerases can replace POLB i...

biorxiv.org

Those amazing moments when Wildlife Photographers get wildlife visitors 😍

Our work describing a phospho-activated DNA polymerase δ-RPA interaction and how RPA-ssDNA scaffolds break-induced replication is now available as published article! 📚 www.nature.com/articles/s41...

Break-induced replication is enhanced by a phospho-activated RPA-binding module in Pol32 - Nature Communications

Break-induced replication (BIR) is mediated by DNA polymerase d (Pol d). Here, the authors identify a phospho-activated RPA-binding module in Pol d which promotes BIR efficiency, providing a paradigm ...

nature.com

Fantastic to host Anna, and thank her for a terrific talk at the GDSC, today.

Uli Rass@u-rass.bsky.social · 3mo ago

A pleasure to host Ilirjana Bajrami from @crick.ac.uk @westlabcrick.bsky.social at the Genome Centre in Sussex @gdsc-sussex.bsky.social today for a fantastic talk on the effects of PARPi at centromeric DNA.

Complementary Holliday Junction observations now available to absorb from @martinxaver.bsky.social and coauthors! www.biorxiv.org/content/10.6...

NealeLab@labneale.bsky.social · 5mo ago

Fantastic to share the work of @whgittens.bsky.social and Tom Powell. World-first detection of Topoisomerase 3 activity on chromosomes in vivo. Top3 maps to meiotic hotspots then migrates, indicating that branched Holliday junctions migrate codirectionally with transcription; resolve at the axis.

Dear all, please see link below for Milano et al, describing a role for BRCA2 (& BRCA1) in the maturation of nascent DNA strand gaps during DNA replication in the presence of PARP inhibitor. Congratulations Larissa and all ! authors.elsevier.com/a/1mtQe3vVUP...

Exciting work from the Rass lab, and colleagues at the GDSC 🥳

Uli Rass@u-rass.bsky.social · 11mo ago

My first post on bsky to share our latest research in @nature.com: “DNA2 enables growth by restricting recombination-restarted replication” - defines DNA2’s essential function & elucidates links with primordial dwarfism and cancer. Thanks to the lab, collaborators & @ukri.org @acmedsci.bsky.social

Our latest study is out in Nucleic Acids Research. FEN1 is critical for rapid single-strand break repair in G1 phase url: academic.oup.com/nar/article/...

FEN1 is critical for rapid single-strand break repair in G1 phase

Abstract. Flap endonuclease 1 (FEN1)-dependent long-patch repair has been considered a minor sub-pathway of DNA single-strand break repair (SSBR), activate

academic.oup.com

🗣️ #WomeninScience at IOCB cordially invite you to the next event in the #DanaHockoválecture series by Dr. Hana Hanzlíková ( #UniBern/ @imgprague.bsky.social @czechacademy.bsky.social). See more ► www.uochb.cz/en/event-cal... ⤵️

Our latest study is now online! A great collaboration between the @fgh-lab.bsky.social and @enriquedealava.bsky.social Labs, driven by the outstanding work of J. Olmedo-Pelayo at @ibis-investigacion.bsky.social Check it out!

EWS::FLI1-DHX9 interaction promotes Ewing sarcoma sensitivity to DNA topoisomerase 1 poisons by altering R-loop metabolism - Oncogene

Oncogene - EWS::FLI1-DHX9 interaction promotes Ewing sarcoma sensitivity to DNA topoisomerase 1 poisons by altering R-loop metabolism

nature.com

Dear all, Postdoc positions are available to work on (1) the role of DNA strand break repair proteins during DNA replication and (2) the molecular/structural biology of XRCC1 protein complexes, as part of our work on genetic diseases & cancer. Contact me if interested: k.w.caldecott@sussex.ac.uk

Dear all, over Christmas I was sadly informed that Larry Thompson died on Dec.16th. Those of you that knew Larry and his work will know how big a loss this is to the genome stability community. A brief memoriam and tribute to Larry is available in DNA Repair. authors.elsevier.com/sd/article/S...

The Genome Damage and Stability Centre at the University of Sussex has now joined BlueSky! Follow us here, for news, views and publications.

This meeting is always very very special…..don’t miss it.

Orlando D. Schärer@orlandoscharer.bsky.social · 2y ago

What are your plans for October 2025? It would be a fantastic time to visit Norway for the Endogenous DNA Damage and Repair conference with a stellar set of speaker covering a wide range of topics. www.endodnadamage.com

Dear all, my first post! I have postdoc positions available if you would like to join my lab in beautiful Sussex by the Sea! Please contact me on k.w.caldecott@sussex.ac.uk