A new Crnic Institute study reveals people with Down syndrome show consistent signs of liver dysfunction across the lifespan.With support from the Global Down Syndrome Foundation, this research offers hope for simple, actionable interventions to support better health. Learn more at bit.ly/4jQOLHD.

Excited to share this work. A huge effort from many team members, led by former @cuhmggp.bsky.social PhD student and current @crnicinstitute.bsky.social Post-doc, Dr. Lauren Dunn! Altered hepatic metabolism in Down syndrome: Cell Reports www.cell.com/cell-reports...

Altered hepatic metabolism in Down syndrome

Dunn et al. show that individuals with Down syndrome display widespread evidence of altered hepatic function in the plasma proteome and metabolome, typified by elevated plasma bile acids. Using a mous...

cell.com

Congratulations to Dr. Paula Arya, Dr. Joaquin Espinosa and Dr. Kelly Sullivan for leading a new study published in iScience entitled "Interferon signaling modulates Down syndrome-associated Alzheimer’s disease pathology in a mouse model." Read more at https://bit.ly/3Io31cK.

As Postdoc Appreciation Week ends, we celebrate our three outstanding postdocs at the Crnic Institute. Thank you, Dr. Brian Niemeyer, Dr. Sara Sherman and Dr. Ariel Timkovich, for your invaluable contributions. Our mission to advance Down syndrome research wouldn’t be possible without you!

We need research heroes! Researchers at the Crnic Institute and Boys Town National Research Hospital are working together to better understand hearing and balance in people with Down syndrome from September 8-13 at Children's Hospital Colorado. Learn more: bit.ly/HearinginDS

Registration is open for the annual Crnic Institute Down Syndrome Research Symposium on September 15, 2025! This in-person event will take place on the 2nd floor of the Anschutz Health Sciences Building. Register today at https://bit.ly/DS-Symposium.

Congratulations to Dr. Kelly Sullivan, director of the Crnic Institute’s Experimental Models Program and associate professor at @cupediatrics.bsky.social‬, on presenting ”The Interferonopathy of Down Syndrome,” and to Rachel Shropshire for winning Top Student Poster at this year’s DSMIG Symposium!

The 2026 Program will heavily emphasize co-occurring conditions and tissue systems affected by T21. We encourage diversity in the composition of symposia speakers with respect to geography, academic rank, and gender. Society members at all career stages are welcome to submit symposia.

Kelly Sullivan@kellydsullivan.bsky.social · last yr.

The theme for the 6th International Conference of the Trisomy 21 Research Society will be, “T21: Insights from Across the Lifespan”. Each symposium will consist of four speakers in a 2-hour block and should include both basic and translational components to foster discussion among research teams.

The theme for the 6th International Conference of the Trisomy 21 Research Society will be, “T21: Insights from Across the Lifespan”. Each symposium will consist of four speakers in a 2-hour block and should include both basic and translational components to foster discussion among research teams.

Kelly Sullivan@kellydsullivan.bsky.social · last yr.

Planning for next years T21RS International Conference in Denver is under way! Call for Symposia will open on August 15. If you have any questions, please don't hesitate to reach out. www.t21rs.org/5th-t21rs-in...

Planning for next years T21RS International Conference in Denver is under way! Call for Symposia will open on August 15. If you have any questions, please don't hesitate to reach out. www.t21rs.org/5th-t21rs-in...

Are you bravely deciding to do a postdoc in the US? And also interested in some combination of genomics, immunology, and transposons? If so, consider applying to my lab at the BioFrontiers Institute in Boulder, Colorado! jobs.colorado.edu/jobs/JobDeta... 🧪🧬 #TESky #interferosky

New research opportunity! Researchers at the Crnic Institute and Boys Town National Research Hospital are working together in Dallas, TX, to better understand hearing and balance in people with Down syndrome. Compensation is provided. Learn more and schedule an appointment at bit.ly/HearinginDS.

Some news....Rome is not fully burned down. T32 PhD Training Grant was officially awarded, and two weeks ago, the NIH offered more support than requested to increase the # trainees in the unique program. Office chair with me in it levitated. Calling Microbime PhD'ers to @psumbiome.bsky.social 🎓

NIH and FDA hosted a workshop on July 7 on efforts to reduce the use of animal models in research, NIH has formally announced a policy change. The agencies have invited comments through the workshop’s webpage. PLEASE COMMENT. The portal will be open until 5pm ET on Monday, July 14 (TODAY).

Congratulations to Dr. Jason Wilson of @cuhmggp.bsky.social on successfully defending his dissertation yesterday! You can check out some of his work here: www.biorxiv.org/content/10.1...

Grateful to meet with students from CU Boulder’s CU in DC program. Appreciated their thoughtful and insightful questions!

Delighted to share our updated work, led by postdoctoral fellow Dr. Maria Campaña, published in @natcomms.nature.com: rdcu.be/em66g, PDGFRalpha/beta heterodimer activation negatively affects downstream ERK1/2 signaling and cellular proliferation

PDGFRα/β heterodimer activation negatively affects downstream ERK1/2 signaling and cellular proliferation

Nature Communications - Here they show that heterodimerization of the receptor tyrosine kinases PDGFRa and PDGFRb negatively affects downstream ERK1/2 signaling and cellular proliferation, due in...

rdcu.be

Maybe someone needs to say this out loud, but computers can't model the physiology of a living organism because we don't know how many of the parts of an organism work, which is uhhh... why we do the research with the animal models?

Tal Kopan@talkopan.bsky.social · last yr.

Kennedy, who often says the administration intends to support "gold-standard science," says NIH is phasing out animal studies because “We can accomplish a lot of those goals on safety and efficacy with AI technology.”

ICYMI - “This is life and death stuff for Americans and for Coloradans.” – Rep. Jason Crow sentinelcolorado.com/metro/trump-... #TrumpCuts #COpolitics #DOGE

Trump budget cuts threaten Anschutz healthcare, research and jobs, officials say - Sentinel Colorado

"This is life and death stuff for Americans and for Coloradans." - Rep. Jason Crow

sentinelcolorado.com

Thank you Congressman @crow.house.gov for visiting the #CUAnschutz Medical Campus to learn more about our latest breakthroughs and the vital role of federal funding in driving lifesaving new medical discoveries.

It was a pleasure to have Kristina Sisneros from Regis University for her GLOBAL Inclusive Program Internship! Thank you to GLOBAL for supporting this amazing opportunity, and congratulations to Kristina on all her hard work.

Wow.

Shicheng Guo@shihcheng.bsky.social · last yr.

Activation of Wnt & STAT3 signalling allows long-term self-renewal (1), STAT3 focusses function while YAP drives biliary lineage, balancing replication & function. PMID:40240606, Nature 2025, @Nature https://doi.org/10.1038/s41586-025-08861-y #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Hi Folks! Myself and the Barberan Lab at U of A are still looking for a PhD student to work on an NSF funded project exploring effects of fire and invasion on soil microbes. We are looking for someone to start in Fall! SOON! Email me if you are interested! PLS Repost! @EsaSeeds

striking to me that this interview ends with him plaintively pleading for other university leaders to speak up: "I don’t think this is all about Princeton. It’s about what’s happening in the United States. I think this would be so much stronger if many more of my fellow presidents were speaking up."

Josh Braun@joshbraun.bsky.social · last yr.

I greatly appreciate everything that Christopher Eisgruber says in this interview, but, more than that, it's increasingly a relief to hear someone in a position of authority willing to be sane in public. #academicSky #eduSky www.nytimes.com/2025/04/09/p...

Powerful new Washington Post story up... wapo.st/426d9fT (Gift link) 1/n

Trump promised scientific breakthroughs. Researchers say he’s breaking science.

NIH funding for biomedical research has abruptly fallen by billions of dollars, with many grant decisions on hold. Trump officials say they’re reviewing the agency.

wapo.st

Are you wearing different socks to celebrate #WorldDownSyndromeDay ? Join in!!! It's fun!!!

Liz Herrieven@drlizherrieven.bsky.social · last yr.

Tomorrow is #WorldDownSyndromeDay! The 21st day of the 3rd month, aa people with Down syndrome have 3 copies of chromosome 21 instead of 2. We wear “lots of socks” to celebrate. Bright, funky, mismatched (not odd!), because different is good, and because chromosomes look a bit like socks 😊

Was very excited to host Senator Hickenlooper in my lab this past week, as well as be involved in a panel discussion around the important of federal funding for science! coloradosun.com/2025/03/19/n...

Funding cuts to CU-Anschutz could erase years of medical research contributed by patients, advocates fear

NIH funding cuts could halt years of progress on medical research contributed by patients at Colorado's CU-Anschutz campus.

coloradosun.com

Tomorrow is World Down Syndrome Day (3/21)! We have made great strides in understanding Down syndrome and improving healthspan for this amazing community, but there is much work to be done. Honored to be part of the Trisomy 21 Research Society Executive Board. www.thelancet.com/journals/lan...

Advocating for increased awareness and research on Down syndrome

World Down Syndrome Day, observed annually on March 21 and recognised by the UN since 2012, aims to raise awareness of Down syndrome to help people better understand and support those with the conditi...

thelancet.com

Be part of research progress! Our researchers are working with @boystownhospital.bsky.social to learn more on balance and hearing in #Downsyndrome. This single appointment includes balance exercises and a hearing test with results given on site. Learn more: bit.ly/3R4Ogwl

Join us this Wednesday, March 19th, for our monthly Supergroup presentations! This event is open to all Crnic Institute Members. If you are not a member and are interested in data science presentations, visit bit.ly/CrnicMember. @caylajewett.bsky.social