👋 Hi antiphage defense community, we are soon releasing an update of DefenseFinder. We are doing our best to include all the great discoveries from the community, but with so much going on we might miss things. Please answer wt preprints/papers with new systems or mail/git them to us. 🙏

OUT NOW - Streptomyces secretes a siderophore that sensitizes competitor bacteria to phage infection www.nature.com/articles/s41...

Streptomyces secretes a siderophore that sensitizes competitor bacteria to phage infection - Nature Microbiology

A secondary metabolite sensitizes competitor Bacillus subtilis to a wide panel of lytic phages by sequestering iron and preventing the activation of Spo0A.

nature.com

We found that many bacterial species use exogenous peptidoglycan fragments - released by lysis of neighboring cells - as a general danger signal, triggering a danger response that protects bacteria against many dangers: biofilm formation. Details here 👇 www.nature.com/articles/s41...

Bacteria use exogenous peptidoglycan as a danger signal to trigger biofilm formation - Nature Microbiology

Peptidoglycan released by neighbouring kin or non-kin cell lysis induces physiological changes that protect from a range of stresses, including phage predation.

nature.com

'But a new systematic analysis of what some call the “dark proteome” suggests scientists have missed thousands of nontraditional genes that lurk in previously overlooked stretches of the genome and make smaller than average proteins.' www.science.org/content/arti...

‘Dark proteome’ survey reveals thousands of new human genes

Database confirms that overlooked segments of the genome code for a multitude of tiny proteins

science.org

Excited to share this new publication where we review the current stand of Phage-Plasmids (P-Ps), check it out! @fnobrega.bsky.social portlandpress.com/essaysbioche...

Characteristics of phage-plasmids and their impact on microbial communities

Abstract. Bacteria host various foreign genetic elements, most notably plasmids and bacteriophages (or phages). Historically, these two classes were seen as separate, but recent research has shown con...

portlandpress.com

Get ready to dance, our paper – Phage DisCo: targeted discovery of bacteriophages by co-culture – has been pre-printed! 🪩 This has been a really fun project to work on with @sianowen.bsky.social, @baym.lol, @nquinoneso.bsky.social, and our two talented undergrads Kesther and Carmen!

bioRxiv Microbiology@biorxiv-microbiol.bsky.social · 2y ago

Phage DisCo: targeted discovery of bacteriophages by co-culture https://www.biorxiv.org/content/10.1101/2024.11.22.624878v1

Ever thought that only tailed phages really matter? Our latest paper reveals that non-Caudoviricetes prophages could be more important than you'd expect. Curious? Read more here: academic.oup.com/ismej/advanc...

Prophages in Vibrio

Abstract. Although tailed bacteriophages (phages) of the class Caudoviricetes are thought to constitute the most abundant and ecologically relevant group o

academic.oup.com