One of this morning's talks is @kevin-dean.bsky.social explaining how to do cyclic IF for ExM #I2KxBINA

I’m excited to share that I’ll be joining the Mindspan Institute in Cambridge this November as Founding Head of Integrated Imaging Systems, working with an incredible team to tackle one of the most ambitious projects in neuroscience. mindspaninstitute.org

I'm shocked.

It's an exciting day for #Fiji users! Now read and write @zarr.dev v3 and #OMEZarr v0.5. Don't want a million tiny files in your #zarr? Shard that sucker! Read the details here forum.image.sc/t/fiji-can-r...

Fiji can read and write Zarr3 & OME-Zarr v0.5 (new N5 release!)

Updating your Fiji-Latest installation will give you the newest versions of the N5 library, enabling OME-Zarr v0.5 / Zarr v3 support with sharding! What's new? Reading zarr 3 datasets (sharded and u...

forum.image.sc

New preprint! Using multiscale ExM/OPM/ASLM, we show that oncogenic drivers leave distinct 3D architectural fingerprints in intact liver tissue: NRAS primarily remodels cell shape, whereas CTNNB1 shifts mitochondrial architecture toward a pericentral-like state. tinyurl.com/kepy33m6

Deciphering the Multiscale Morphology of Somatic Oncogenic Alterations in Hepatocellular Carcinoma

Somatic oncogenic mutations are typically defined by their molecular alterations, yet how they reorganize cellular architecture within intact tissues remain largely unknown. Here, we demonstrate that ...

biorxiv.org

A fun activity… get some goggles, have something floating just beneath the surface of a pool, and adjust your viewing angle under water. See total internal reflection in action.

We’re adding Blender-based tutorials on optical alignment to ALTAIR: thedeanlab.github.io/altair/getti... Our goal is to make optical alignment more intuitive and accessible for both experts and non-experts working with optical systems. Have an idea for a guide? Let me know!

Faculty search announcement 2026: Tenure-Track Assistant Professor in Microbiology at UT Southwestern in Dallas. We seek candidates working in microbial pathogenesis (broadly defined). Come join our community! (1/5) www.utsouthwestern.edu/departments/...

How do places like this exist?

Very excited to be sharing our new paper, just out in Nature Cell Biology! The big question we investigate: How do migrating cells put their front 🔴 and back 🔵 in the right place?

We’re hiring an optical systems engineer / scientist to help build and disseminate Altair, our open, modular light-sheet microscopy platform. Ideal for someone with serious hands-on experience in optical design, Zemax, CAD, alignment, and microscopy. Apply here: www.linkedin.com/jobs/view/44...

Data bite: Why science is becoming less innovative www.economist.com/the-world-in... from The Economist

The world in brief | The Economist

Catch up quickly on the global stories that matter

economist.com

Some stars burn bright, and go dark too soon. Take care of yourself, and seek help when you need it.

We got multiple times the feedback that oblique plane microscopes are too complex. So how about a detection train with only two photographic lenses? www.biorxiv.org/content/10.6...

Kevin Dean@kevin-dean.bsky.social · 5mo ago

Altair Direct View OPM Preprint! We built a simplified direct-view oblique-plane microscope for imaging big, optically accessible specimens with a single-objective light-sheet geometry. Delivers... • ~5.4 mm field of view • ~2.6 μm, ~3.4 μm, and ~17.8 μm resolution in X/Y/Z

Altair Direct View OPM Preprint! We built a simplified direct-view oblique-plane microscope for imaging big, optically accessible specimens with a single-objective light-sheet geometry. Delivers... • ~5.4 mm field of view • ~2.6 μm, ~3.4 μm, and ~17.8 μm resolution in X/Y/Z

Some great tutorials here! www.youtube.com/@LiveCellIma...

Live Cell Image Analysis

We are leaders of two NIH-funded research centers with national outreach in cancer cell imaging (grants RM1GM145399 and U54CA268072). This channel provides demonstrations and tutorials for the u-quant...

youtube.com

It’s a Commodore weekend.

🔬🔦In this Imaging spotlight, Kevin Dean @kevin-dean.bsky.social and team tell us about their motivation for designing Altair-LSFM, describe its key features, how to setup and use the system and their planned developments. focalplane.biologists.com/2026/03/09/i...

Imaging spotlight: Altair-LSFM - FocalPlane

Imaging spotlight: Altair-LSFM - News

focalplane.biologists.com

Photon unlimited contrast. Axially swept light-sheet microscopy using scattering and fluorescence contrast mechanisms. www.spiedigitallibrary.org/conference-p...

I’ve been experimenting with AI agents for coding, and honestly: anyone calling it “AI slop” hasn’t really dabbled with the drug. Give these things the right tools and they absolutely shine. Have an idea? Build it.

www.nature.com/articles/s44...

Smart microscopy: adaptive microscope control to improve the way we see life - npj Imaging

npj Imaging - Smart microscopy: adaptive microscope control to improve the way we see life

nature.com

Altair-LSFM – new high-resolution, open-source, sample-scanning approach to light-sheet fluorescence microscopy for sub-cellular imaging 📹 @john-haug.bsky.social et al @kevin-dean.bsky.social lab UT Southwestern Medical Center in @elife.bsky.social ➡️ bpod.org.uk/archive/2026... with John Ankers

bpod.org.uk

BPoD | Easy Cell

BPoD (Biomedical Picture of the Day) is a free educational resource showcasing biomedical imagery. Managed by the MRC Laboratory of Medical Sciences the website aims to engage the general public. Imag...

bpod.org.uk

We’re excited to announce the next Fluorescent Proteins & Biological Sensors conference! Abstract submissions are now open—hope to see you there. www.janelia.org/you-janelia/...

Today’s bounty

In @elife.bsky.social: A high-resolution, easy-to-build light-sheet microscope for subcellular imaging doi.org/10.7554/eLif...

A high-resolution, easy-to-build light-sheet microscope for subcellular imaging

An accessible light-sheet microscope delivers subcellular-resolution, multicolor volumetric, and live-cell imaging, lowering barriers to state-of-the-art performance.

doi.org

We have two funded postdoctoral positions available. Topics encompass: -Next gen light-sheet fluorescence microscopy instrumentation -Structured illumination microscopy and other approaches to extend the resolution limit. -Nonlinear microscopy combined with adaptive optics / phase conjugation

You know a grant is due shortly when your children stop sleeping through the night, and school gets closed for multiple days.

DNA PAINT in a drosophila embryo. I'm impressed. www.cell.com/biophysj/ful...

Navigate can now run entirely with ASI's Tiger Controller, eliminating the NI data acquisition board altogether, simplifying the optoelectronics, and providing deterministic frame-to-frame operation. Documentation coming soon... github.com/TheDeanLab/n...

GitHub - TheDeanLab/navigate: navigate - open source light-sheet microscope controls

navigate - open source light-sheet microscope controls - TheDeanLab/navigate

github.com