For the last 5 years, my lab has focused on developing mutational scanning methods and learning how to answer specific questions in protein biology. @matthewkhoward.bsky.social and I wrote a review on experimental decisions and future directions for our nascent field! doi.org/10.1146/annu...

Mechanistic Mutational Scanning to Uncover the Secret Life of Proteins

Deep mutational scanning (DMS) has emerged as a transformative tool for dissecting individual protein function and broader cell biology. DMS methods enable comprehensive interrogation of sequence–func...

annualreviews.org

We're excited that plasmid for HYlight2, our improved sensor for fructose 1,6-bisphosphate, are now available on @addgene.bsky.social Pre-print here: www.biorxiv.org/content/10.6...

🚀 Marie Curie Postdoc: Call for Interest – Target mitochondrial AURKA/PHB2 in breast cancer Express interest to co-write a proposal with us! Ideal for mitochondrial biology & quantitative imaging experts. 📅 Interest deadline: 31 May 2026 📩 Apply here: euraxess.ec.europa.eu/jobs/hosting...

Call for Expression of Interest to host a Marie Curie Postdoctoral Fellow: Exploring the effects of next-generation pharmacological inhibitors of mitochondrial turnover by mitophagy in cancer cells

euraxess.ec.europa.eu

📢 Applications are open! Join us in October to explore next-generation fluorescent proteins, biosensors & imaging advances + machine learning and computational approaches to accelerate design. 🛏️ Meals & lodging covered; no registration fee Apply by May 21 ➡️ janelia.news/FPS26 @agtebo.bsky.social

We’re excited to announce the next Fluorescent Proteins & Biological Sensors conference! Abstract submissions are now open—hope to see you there. www.janelia.org/you-janelia/...

New preprint! Our work together with @agtebo.bsky.social : our 'NanoBlocks' strategy to generate fluorescent biosensors from binders such as nanobodies. Proof-of-concept sensors with ALFA nanobody & Erbin PDZ domain shows the concept in vitro, in cells, and for FACS. www.biorxiv.org/cgi/content/...

NanoBlocks: creating fluorescent biosensors from affinity binders using competitive binding

Genetically-encoded fluorescent biosensors have revolutionized our understanding of complex systems by permitting the in situ observation of chemical activities. However, only a comparatively small se...

biorxiv.org

Interested in metabolism? So are we! My lab has been exploring the cell biology of energy metabolism in the nervous system, and we are looking for postdocs. Cool sensors and microscopy, great work environment. Please help me spread the word!

We are recruiting for a project extending our current work using machine learning for fluorescent biosensors at Janelia! We have both experimental and computational positions posted: hhmi.wd1.myworkdayjobs.com/en-US/Extern... hhmi.wd1.myworkdayjobs.com/en-US/Extern...

AI Engineer - Metabolic Sensor Design

Primary Work Address: 19700 Helix Drive, Ashburn, VA, 20147 Current HHMI Employees, click here to apply via your Workday account. Intro: AI@HHMI: HHMI is investing $500 million over the next 10 years ...

hhmi.wd1.myworkdayjobs.com

📢We're #hiring Group Leaders! Apply to lead a lab at Janelia & advance biology using theory, computational modeling & machine learning. 🔹5-year renewable appointment 🔹Pioneer new tools & approaches 🔹Collaborate across disciplines Apply by Nov. 4👉 https://janelia.link/groupleader

Applications are now open for the 4th edition of the “Ecole de Physique des Houches” on Fluorescence Markers for Advanced Microscopies, a WE-Heraeus seminar. March 15th-20th 2026 Join us to learn everything you wanted to know about Fluorescent Markers for advanced microscopies.

"I'm still in shock. I know that there have been political issues around Harvard in recent weeks, but antibiotic resistance isn't one of them." My conversation with Harvard microbiologist @baym.lol, one of many researchers there who just lost millions in fed. grants. www.wbur.org/news/2025/05...

Antibiotic research at Harvard lab threatened by federal funding cuts

Microbiologist Michael Baym studies antibiotic resistance at Harvard Medical School. He lost millions in federal funding this week.

wbur.org

$95 b return on a $37 b investment. Federally funded research is a good return - even without, you know, remarkably effective new treatments for cancer, curing genetic disorders, making progress and improving the lives of those with neurodegenerative disease, etc. www.forbes.com/sites/michae...

NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report

National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.

forbes.com

🧪Rhobo6, a light microscopy probe developed by the Pedram Lab & collaborators, gives scientists an unprecedented look at the extracellular matrix—the collection of organized molecular structures that fills the spaces between cells in our bodies. www.janelia.org/news/looking...

Looking between cells

Before arriving at Janelia three years ago, Postdoctoral Scientist Antonio Fiore was designing and building optical instruments like microscopes and spectrometers. Fiore, a physicist by training,

janelia.org

the lab is recruiting scientists! we are particularly excited about engineering fluorescent proteins and biosensors using high-throughput assays and machine learning. questions? please get in touch!

As West Virginia University plans to cut apparently its entire foreign language program, it's whole graduate program in math and a slew of other traditional liberal arts, it seems worth resurfacing my NYTimes piece from last April:

Opinion | Colleges Should Be More Than Just Vocational Schools

Elected officials have pushed vocational programs at the expense of the liberal arts. That’s hurting America.

nytimes.com

I asked an Indigenous colleague in Hawai'i where people can donate to and these were his suggestions (1/2): Hawaiʻi People's Fund: https://hawaiipeoplesfund.networkforgood.com/projects/200566-maui-aloha-the-people-s-response-fund ʻĀina Momona: https://secure.actblue.com/donate/kokuamaui

Maui Aloha: The Peopleʻs Response

Support our frontline grassroots heroes mobilizing to mālama ʻohana affected by the wildfires on Maui Hawaiʻi People’s Fund stands in solidarity and full support with those individuals and organ...

hawaiipeoplesfund.networkforgood.com