New preprint! How does a cell "know" how big to make its nucleus? This has puzzled biologists since the 1800’s. We show the answer is physics: colloid osmotic pressure. 🧵1/5

bioRxiv Biophysics@biorxiv-biophys.bsky.social · 2w ago

Nuclear size and physical properties of the nucleoplasm are determined by colloid osmotic pressure at the nuclear envelope https://www.biorxiv.org/content/10.64898/2026.07.21.739918v1

Very honored to be featured in Cytoskeleton Spotlight! If you would like to learn a bit more about me and my research, but also discover the answers to critical questions such as which cytoskeletal protein I would swap places with for a day be sure to check it out! @cytoskeljournal.bsky.social

I have the print copy!! It's so exciting to see my art on the cover and @henrydebelly.bsky.social's paper in print! Thanks Orion! @oweinerlab.bsky.social!

🪲🪰 Our preprint is out! This was a team effort with @wolframponisch.bsky.social, @matthewabenton.bsky.social and Ewa Paluch. We asked whether Drosophila and Tribolium use the same cell behaviours to fold their embryos during gastrulation. 🧵👇 www.biorxiv.org/content/10.6...

Morphospace analysis reveals divergent cellular behaviours driving tissue internalisation during insect gastrulation

During gastrulation, embryonic epithelia undergo large-scale remodelling to internalise the mesoderm. Whether the cellular mechanisms underlying these tissue deformations are conserved across species ...

biorxiv.org

Thrilled to share new collaborative work with the lab of Leah Edelstein-Keshet and @oweinerlab.bsky.social , led by Edwin Huras 👏

We made the cover 🤩 !! Check out this incredible painting by @kahsage.bsky.social !!

The first webinar in our #FocalPlaneFeatures #CellMigration webinar series is tomorrow (Thursday 11 June) at 15:00 BST (UTC+1). Join us via Zoom to hear from @juanmagararc.bsky.social, @kyohalie.bsky.social & @djcohen.bsky.social. focalplane.biologists.com/2026/05/29/n...

Very excited to be sharing our new paper, just out in Nature Cell Biology! The big question we investigate: How do migrating cells put their front 🔴 and back 🔵 in the right place?

Check out Evelyn's latest work. This is a beautiful story on how Arachidonic Acid regulates neutrophil swarm initiation. Come for the science, stay for the incredibly beautiful figures and movies 🤩

Evelyn Strickland@strickland-evelyn.bsky.social · 4mo ago

What if you got to work with some of your best friends on a science project? I can't publish how fun this was, but I can show you the data (🧵)! Last week, we posted our second neutrophil swarming paper to bioRxiv and I wanted to post my favorite videos here~ www.biorxiv.org/content/10.6...

Learn more about CRI's newest investigator @henrydebelly.bsky.social and his #relentlessdiscovery to define the molecular controls of membrane fluidity in order to influence immune and #cancer cell function. 👇 cri.utsw.edu/meet-dr-henr... 🧪

Meet Dr. Henry De Belly - Children's Medical Center Research Institute (CRI) | Dallas Texas

Henry De Belly, Ph.D., the newest CRI faculty member, launched the De Belly Lab in early 2026 and joins the CRI Tissue Regeneration Program. Henry grew up in France and earned a bachelor’s in immunolo...

cri.utsw.edu

My lab @cri-utsw.bsky.social is looking for a highly motivated postdoct interested in mechanobiology! We are building a highly collaborative and interdisciplinary team working on how mechanical forces shape immune and cancer cell behavior. Come do cool science with me! lnkd.in/gKEXWUGy

Got these evil-looking pipette aids for the lab and damn are they cool

🚨NEW PI ALERT🚨 @henrydebelly.bsky.social is in the house, and look at that *fresh* new office. Clean slate for his next #relentlessdiscovery in CRI's Tissue Regeneration Program (TRP). Onward! Read more about his new lab 👉 cri.utsw.edu/faculty/henr... 🧪 @haozhulab.bsky.social

Today marks the end of my postdoctoral training at @oweinerlab.bsky.social at UCSF and the beginning of a new chapter @cri-utsw.bsky.social

Super excited to share that I will be starting my lab at UT Southwestern Medical Center this January! We will explore how lysosomes drive cellular metabolism and signaling to better understand disease to develop new therapies for cancer and neurodegeneration. More info here: aakritijainlab.com

Privileged to have been involved in this great story led by Franklin from the Burkhardt's lab, showing the role of S1P in controlling naive T cell motility! www.biorxiv.org/content/10.1...

S1P induces bleb-based T cell motility via S1PR1-dependent activation of RhoA and WNK1

In vivo, the chemokine CCL19 and its receptor CCR7 control T cell retention in lymph nodes, while the lipid chemoattractant spingosine-1-phosphate (S1P) drives T cell egress from lymphoid organs. CCL1...

biorxiv.org

Thrilled to announce the launch of my lab @cri-utsw.bsky.social at UTSW this January! We will explore how cells sense and respond to mechanical forces, focusing on membrane mechanics to reveal how tension and signaling work together to shape cell behavior.

Children's Research Institute at UT Southwestern@cri-utsw.bsky.social · 10mo ago

We're growing! Our newest Investigator @henrydebelly.bsky.social will join the CRI Tissue #Regeneration Program in January 2026. Learn more about Henry ➡️ cri.utsw.edu/faculty/henr... and 📌apply to research in his lab cri.utsw.edu/careers

@henrydebelly.bsky.social @oweinerlab.bsky.social elegantly showed how migrating cells exhibit a long-range mutual activation and partitioning of GTPases at both the front and back of the cell, functioning as an integrated mechano-chemical system. He’s also recruiting for his new lab!🧑‍🔬#MBIMPG2025

Ever wished to become an actin star? 😎 Then try getting suspended above a non-adhesive substrate. www.nature.com/articles/s41...

A multicellular star-shaped actin network underpins epithelial organization and connectivity - Nature Communications

The combined role of cellular junctions and actomyosin networks in tissues remains unclear. Here, the authors identify a tissue-scale star-shaped network of actomyosin that preserves cell shape, limit...

nature.com

I'm thrilled to announce that my lab is opening this August in the Department of Cell & Tissue Biology @ UCSF! We will study airway stem cells and explore how they generate multiciliated cells (my favorite!) to keep pathogens and debris out of the lung. Check out choksilab.org for more!

CTB welcomes new Assistant Professor Semil Choksi @semilc.bsky.social to the department! The Choksi Lab will study how airway stem cells generate multiciliated cells - and how this process goes wrong in respiratory disease. His lab is opening this August. Visit choksilab.org to learn more!

#Science Bluesky, do your thing: We're organising the International Symposium on Mechanobiology (ISMB) 2026 in #Glasgow & we're looking for research groups in Latin America & Africa who are doing great work in #Mechanobiology or adjacent areas. Can you indicate some names to me?

All of NIH funding to Northwestern University is frozen. This pause includes noncompeting approved funding, new and competing grants with fundable scores. No reimbursements for money already spent have been received since March. This situation is rarely reported so please Please get the word out!

I am a proud HHMI Gilliam Fellow alumn. The HHMI funded me at a critical time in my career - a real inflection point that made me realize that I had a place and future in science. I always looked to the HHMI as a safety net to those historically excluded by academia, 1/4

🚨📣 New preprint alert! Excited to share my new postdoc work on direct force and mechanical properties measurements in live embryos! A great team effort with A. Chamolly (theory), under the supervision of F. Corson and @jeromegros.bsky.social 📄 www.biorxiv.org/content/10.1... #devbio #mechanics

Direct measurements of active forces and material properties unveil the active mechanics of early embryogenesis

Despite progress in probing tissue mechanics, direct long-term measurements in live embryonic epithelia are lacking. This limits our understanding of amniote embryonic morphogenesis, which takes place...

biorxiv.org

SO excited to share that a major part of the postdoctoral work in @robzonculab.bsky.social lab is now published: “Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins” www.science.org/doi/10.1126/...

Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins

Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset...

science.org

In Memoriam: Wolfenson, Giannone, and Schwartz recall the life and many contributions of Michael Sheetz, who passed away on January 30, 2025. rupress.org/jcb/article/...

born too late to get a two Western blot Nature paper, born too early to be a science TikTokker, born just in time to start a postdoc during a global pandemic and look for faculty positions during a historic hiring freeze

As scientist I am going through difficult times (this is understatement of the year for me!!). Past one and half months have been horrible, however I am trying to pick myself up and super excited to share my postdoc work with the community! #cellmigration www.biorxiv.org/content/10.1...

CD44 and Ezrin restrict EGF receptor mobility to generate a novel spatial arrangement of cytoskeletal signaling modules driving bleb-based migration

Cells under high confinement form highly polarized hydrostatic pressure-driven, stable leader blebs that enable efficient migration in low adhesion, environments. Here we investigated the basis of the...

biorxiv.org

Huge crowds in SF today for #standupforscience. inspiring stories, not only from scientists like @carolynbertozzi.bskyverified.social, but also people who have lived through life-saving/changing experiences as a direct consequence of federally-funded scientific research 💪🏽