Extrinsic factors can create a local tissue environment that encourages restoration @science.org www.science.org/doi/10.1126/... www.science.org/doi/10.1126/... @canaztekin.bsky.social www.science.org/doi/10.1126/... @storerlab.bsky.social @scicambridge.bsky.social @kevinchalut.bsky.social

It was really fun to work on this collaboration with @storerlab.bsky.social and Byron - I think we are really starting to see that ECM is more than just a scaffolding. It's really driving tissue function in important ways, like in this application of tissue repair.

Mekayla Storer@storerlab.bsky.social · 4mo ago

Proud to share this work with @kevinchalut.bsky.social and Byron Mui. Why do some injuries scar while others regenerate? Using digit tip models, we show the ECM is a key driver. HA-rich ECM promotes regeneration, and boosting it can shift healing away from fibrosis. www.science.org/doi/10.1126/...

🚨 New Preprint from the Paluch & Chalut Labs 🚨 Ana Raffaelli et al show that the stiffness of substrate (in vitro) / basal membrane (in vivo) determine how cells interpret biochemical signals (BMP4) and which fates they acquire #mechanobiology #hESCs #substratemechanics doi.org/10.64898/202...

Excited to share this new work from Ana Raffaelli, in collaboration with Ewa Paluch's lab and involving several of my colleagues at Cyclana Bio. In this paper, we show that basement membrane mechanics instructs developmental signalling and fate patterning. www.biorxiv.org/content/10.6...

Excited to share our work on epithelial multilayering - identifying why stem cell stay in the basal layer and how and why differentiating cells move up. Great collab with @manningresearch.bsky.social and Niessen labs! Check out preprint and great summary below www.biorxiv.org/content/10.6...

Manning Research Group@manningresearch.bsky.social · 6mo ago

Excited to highlight a new preprint about mechanical contributions to tissue homeostasis, from the Manning group in collaboration with the amazing Carien Niessen and Sara Wickstrom @sarawickstrom.bsky.social labs, spearheaded by Dr. Somiealo Azote: www.biorxiv.org/content/10.6...

Very excited that the lab's first paper is out! We showed that in stem cells, Aurora B controls abscission dynamics by regulating microtubules stability and MCAK recruitment. Very happy with this streamlined version of our 2024 preprint. www.cell.com/cell-reports...

Aurora B controls microtubule stability to regulate abscission dynamics in stem cells

Mouse embryonic stem cells remain connected by bridges for hours after cell division. In this paper, Kodba et al. show that a high Aurora B activity at the bridge leads to microtubule stabilization. S...

cell.com

We are really proud to share the first 'Pre-Print' from the Storer lab driven by the fantastic Byron Mui, and co-lead by the innovative Kevin Chalut, on tissue mechanics, ECM and regeneration. A big thanks also to our collaborators in the Franze Lab. www.biorxiv.org/content/10.1...

Hyaluronic Acid and Emergent Tissue Mechanics Orchestrate Digit Tip Regeneration

Tissue regeneration is a dynamic process requiring coordinated cell fate decisions to restore structure and function. For instance, the tips of human and rodent digits fully regrow after amputation, a...

biorxiv.org