Happy to share the first preprint from our lab, led by @arrosan.bsky.social, in collaboration with @ccb-lab.bsky.social. We identify a conserved cohesin-interacting motif in Red1 required for its recruitment, DSB formation, and Mek1 activation. www.biorxiv.org/content/10.6... #meiosis #recombination

Cohesin–axis interaction via a conserved Red1 motif promotes domain-specific DSB formation and Mek1 activation

Faithful chromosome segregation during meiosis I requires tight control of interhomolog recombination. In budding yeast, the meiotic chromosome axis, built on Rec8-containing cohesin together with Red...

biorxiv.org

Congrats to Chase Morgan @phagemorgan.bsky.social and the phage team!

Vivek Mutalik@vivekmutalik.bsky.social · 4mo ago

The phage nucleus synergizes with an anti-defense protein to resist bacterial immunity: Cell Reports www.cell.com/cell-reports...

Congratulations to Doi Basu @dwaipayanbasu.bsky.social for publishing his first first-author paper from the lab! The cryoEM structure of a tubulin-like protein from bacteriophage Goslar forms "microtubules" with nine protofilaments! authors.elsevier.com/a/1mM253SNvc...

Happy to see our research on SMC Wadjet published in Molecular Cell. We showed DNA loop extrusion (LE) by a bacterial SMC, confirming LE is conserved across all life forms. Wadjet's LE activity is crucial for recognizing and restricting foreign plasmids, serving as a defense mechanism. 🧬🔬🧪

Structural diversity and oligomerization of bacterial ubiquitin-like proteins https://www.biorxiv.org/content/10.1101/2024.11.21.623966v1

Structural diversity and oligomerization of bacterial ubiquitin-like proteins https://www.biorxiv.org/content/10.1101/2024.11.21.623966v1

Bacteria possess a variety of operons with homology to eukaryotic ubiquitination pathways that encod

biorxiv.org

Mechanistic basis for protein conjugation in a diverged bacterial ubiquitination pathway https://www.biorxiv.org/content/10.1101/2024.11.21.623953v1

Mechanistic basis for protein conjugation in a diverged bacterial ubiquitination pathway https://www.biorxiv.org/content/10.1101/2024.11.21.623953v1

Ubiquitination is a fundamental and highly conserved protein post-translational modification pathway

biorxiv.org