A new RNA-based method may help insulin-producing cells survive transplantation. In @sigtrans-sttt.bsky.social, researchers show treated cells restored their blood supply faster, requiring fewer donor islets to normalize blood glucose 🧪 news.ki.se/rna-technolo...

In the rare disease #progeria, blood vessels deteriorate prematurely. A new study shows how different cell types in the vascular wall undergo progressive changes and accumulate mutations over time. Published in Genome Medicine 🧪 news.ki.se/somatic-muta...

A new study in Journal of Experimental & Clinical Cancer Research shows that sodium selenite can reinforce epithelial features and dampen EMT-associated plasticity in pancreatic cancer. The effect was dose- and context-dependent in patient-derived tissues. #PancreaticCancer 🧪

A pilot RCT shows that early double sequential defibrillation in out-of-hospital cardiac arrest is feasible and appears safe, with signals of higher 30‑day survival — informing a larger ongoing trial. Published in Heart. #CardiacArrest 🧪

Patients with #COVID19 can show several different antiviral immune response patterns which may influence how the disease develops. This is shown in a study published in Genome Medicine, highlighting the importance of interactions between the #immunesystem and #metabolism 🧪 news.ki.se/biological-d...

Biological differences linked to severe COVID-19

Patients with COVID-19 can show several different antiviral immune response patterns, which may influence how the disease develops. This is shown in a new study from Karolinska Institutet, published i...

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A healthier #diet may be associated with a lower risk of #dementia among older adults, including those with blood biomarkers indicating an increased biological risk of #Alzheimer's disease pathology, a new study in @jamanetworkopen.com shows 🧪 news.ki.se/healthier-di...

#Obesity is common but often underdiagnosed and linked to a high cardiovascular burden and a markedly increased risk of future cardiovascular disease and premature death. A KI study in Diabetes, Obesity and Metabolism points to a need for improved detection and treatment 🧪 news.ki.se/high-risk-of...

High risk of cardiovascular disease in obesity

Obesity is common but often underdiagnosed in Swedish healthcare and is associated with a high cardiovascular burden and a markedly increased risk of future cardiovascular disease and premature death....

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Systematic reviews and #meta-analyses form the basis for #healthcare and health policy, but access to the data on which the results are based is often lacking. This is shown in a new policy forum article published in the journal @plosmedicine.org 🧪 news.ki.se/lack-of-acce...

Pooled sputum testing with Xpert MTB/RIF Ultra could reduce #Tuberculosis diagnostic cartridge use by 46.5% in Vietnam while maintaining acceptable sensitivity and high specificity, a new study published in @cmijournal.bsky.social shows. #diagnostics #GlobalHealth 🧪 doi.org/10.1016/j.cm...

The thresholds for #kidney function currently used to diagnose chronic kidney disease – #CKD – reflect a true increase in the risk of serious illness, a new study in @jama.com shows 🧪 news.ki.se/risk-thresho...

The 2026 call for Assistant Professorships at Karolinska Institutet is now open. We are recruiting 21 outstanding early-career scientists across a wide range of research areas. Join our team of excellence! ki.se/en/about-ki/...

A population-based study in @jinternmed.bsky.social shows that falls, respiratory infections and heart attacks after age 60 are linked to steeper #frailty trajectories. Preventing acute events, particularly falls, before age 75 may promote healthier #ageing 🧪 onlinelibrary.wiley.com/doi/10.1111/...

<em>Journal of Internal Medicine</em> | Wiley Online Library

Background We aimed to examine the relationship between acute events and frailty trajectories of community-dwelling adults aged 60 and older. Methods We included 3146 participants, aged 60+, from .....

onlinelibrary.wiley.com

#PCOS has been renamed #PMOS (polyendocrine metabolic ovarian syndrome). In @natmed.nature.com, @elisabetsv.bsky.social and others argue that disease names shape care and funding. The new name may reduce delays, stigma and siloed care. #Endocrinology #Diabetes #CVD 🧪 www.nature.com/articles/s41...

Chronic immune diseases are driven by several #inflammatory processes happening simultaneously in different parts of the tissue, a new study in Immunity shows 🧪 Research by @ejvillablanca.bsky.social et al. news.ki.se/chronic-bowe...

Karolinska Institutet continues to grow a global community of excellence. In summer 2026, KI will open a call for multiple new Assistant Professor positions in medicine and health. ki.se/en/about-ki/...

Researchers at KI and @kthuniversity.bsky.social have identified rare DNA changes during fetal development that can lead to bicuspid aortic valve, where the aortic valve forms with only two cusps instead of three. Published in @natcomms.nature.com 🧪 #cardiology #genetics news.ki.se/genetic-stud...

Genetic study reveals cause of common heart valve defect

New clues from genetic research may help explain what causes the most common heart defect present at birth. Researchers at KTH Royal Institute of Technology and Karolinska Institutet have identified r...

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Despite new diagnostic methods and expanded #vaccination programmes, many children in #Uganda continue to suffer from severe brain infections. This is shown in a new study published in The Lancet Regional Health – Africa. news.ki.se/early-warnin...

Addressing iron status may be relevant for #dementia prevention and healthy #ageing, suggests a KI study published in BMC Medicine @bmc.springernature.com. Both absolute and functional iron deficiency were linked to higher dementia risk in older adults. 🧪 #aging doi.org/10.1186/s129...

Iron deficiency and dementia risk: evidence from the Swedish population-based cohort study AMORIS - BMC Medicine

Background Iron deficiency (ID) is proposed to be involved in cognitive aging and dementia; however, empirical data is lacking to support this hypothesis. We examined the association between absolute and functional ID and incident dementia diagnosis. Methods Data from 70,935 individuals aged ≥ 50 years from the Swedish AMORIS cohort, who had blood measurements indicative of iron status between 1985–1996, were used. Participants were followed for incident dementia diagnosis recorded in National Patient Register (inpatient and specialist outpatient) and Prescribed Drug Register (dispensed anti-dementia drugs) for up to 15 years. Two exposure groups were defined: absolute iron deficiency (serum ferritin < 30 ug/L) and functional iron deficiency (transferrin saturation < 20% and serum ferritin ≥ 30 ug/L). The reference group included individuals with measurements in the normal range of hemoglobin, serum iron, and total iron binding capacity. Results A total of 4,994 individuals received a dementia diagnosis over a mean of 12.6 years. Compared with the reference group, absolute and functional ID was associated with increased dementia diagnosis (adjusted hazard ratio (HR) = 1.24, 95% confidence interval (CI): 1.18–1.42; HR = 1.21, 95% CI: 1.05–1.39, respectively), after adjusting for age, sex, education, and comorbidities. The associations were essentially consistent across subgroups, and when further adjusting for kidney function, body mass index, and smoking in subsamples. Conclusions Even though absolute and functional iron deficiency has different underlying mechanisms, we found that both conditions are associated with an increased risk of dementia. Considering that iron deficiency is a pervasive but often neglected health issue in older adults, resolving iron deficiency may be relevant for dementia prevention.

doi.org

A new blood test may improve the mapping of mosquito-borne diseases like dengue, Zika and chikungunya, which are spreading to new regions as temperatures rise. Study from KI and @pasteur.fr published in @natcomms.nature.com today by @vyman.bsky.social et al 🧪 #GlobalHealth news.ki.se/new-blood-te...

Gut bacteria appears linked to how much latent #HIV remains in the blood during antiretroviral therapy, a study in Gut Pathogens shows. Findings suggest the gut #microbiome may influence how much virus persists in the body 🧪 news.ki.se/gut-bacteria...

Anaemia detected in healthcare is associated with an increased risk of both cancer and higher mortality. This is shown in a new population-based study published in BMJ Oncology. The findings may help guide clinical follow-up of patients with anaemia in routine care 🧪 news.ki.se/anaemia-link...

The results of a major international collaboration on scientific reliability are presented in three articles in @nature.com. Around half of previously published research results in #SocialScience and #BehaviouralScience could not be replicated in new experiments 🧪 news.ki.se/half-of-soci...

More patients with heart failure receive the recommended four-drug therapy, but adherence and persistence still need improvement. Better adherence is linked to lower risk of hospitalisation and cardiovascular death, a new study shows in European Heart Journal 🧪 news.ki.se/more-patient...

M-CHAT does not catch all children with #autism in the neonatal high-risk group, shows a study in @jamanetworkopen.com. The researchers see a need to supplement the test with other assessment methods 🧪 news.ki.se/screening-te...

Factors in the blood of patients with #dermatomyositis can impair muscle function by activating a specific inflammatory pathway, finds a KI study published in @ard.eular.org. The results suggest that drugs that block this signalling could counteract muscle weakness 🧪 news.ki.se/clue-to-how-...

Clue to how muscles weaken in dermatomyositis opens door to new drug treatments

Factors in the blood of patients with dermatomyositis can impair muscle function by activating a specific inflammatory pathway. This is shown in a new study from Karolinska Institutet published in Ann...

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Two new KI studies published in @cp-immunity.bsky.social have mapped immune gene variation across multiple global populations and shown how these variations affect the ability to form neutralising antibodies, for example against the #influenza virus 🧪 #Immunology #Genetics news.ki.se/large-mappin...

Large mapping of hereditary differences in the immune system

Inherited variations in antibody genes can affect how we respond to infections and vaccines, show two new studies from Karolinska Institutet published in the journal Immunity. The researchers have map...

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Early treatment for #RheumatoidArthritis leads to significant improvements in pain, fatigue, and quality of life – regardless of whether patients receive biologic drugs or conventional therapy. New KI study published in @thelancetrheum.bsky.social 🧪 #Rheumatology news.ki.se/early-initia...

Early initiation of treatment alleviates symptoms in rheumatism

Early treatment for rheumatoid arthritis leads to significant improvements in pain, fatigue, and quality of life — regardless of whether patients receive biologic drugs or conventional therapy. This i...

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KI researchers have created a detailed map showing how genetic activity is controlled in individual cells of the adult human #brain and #spinalcord. Oligodendroglia retain an epigenetic memory of developmental programs long after these genes are no longer active 🧪 news.ki.se/new-map-reve...

New map reveals how adult brain cells remember their origins

Researchers at Karolinska Institutet have created the first detailed map showing how genetic activity is controlled in individual cells of the adult human brain and spinal cord. The study, published i...

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Gonçalo Castelo-Branco@gocastelobranco.bsky.social · 5mo ago

Our latest in @natneuro.nature.com, lead by Mukund Kabbe, providing single cell epigenomic maps of the human brain and spinal cord with snATAC and our NanoCUT&Tag and finding epigenetic memory in oligodendroglia of developmental programs! www.nature.com/articles/s41...

A study published in @nature.com today presents a new method that makes it possible to generate CAR-T cells inside the body. Several types of #cancer were treated in mice without the immune cells needing to be extracted and processed in a laboratory 🧪 #immunotherapy news.ki.se/immune-cells...

Researchers have developed a rapid and cost efficient sequencing method that can identify antibiotic resistance within the same working day. The technique, called s5PSeq, measures how bacterial ribosomes respond within minutes after exposure to an antibiotic 🧪 news.ki.se/rapid-sequen...