If you or someone you know is interested in joining a fun and productive lab (JP Armache laboratory at Penn State University) to work on exciting projects, please follow or share the link below. psu.wd1.myworkdayjobs.com/PSU_Academic...
Postdoctoral Position
APPLICATION INSTRUCTIONS: CURRENT PENN STATE EMPLOYEE (faculty, staff, technical service, or student), please login to Workday to complete the internal application process. Please do not apply here, a...
psu.wd1.myworkdayjobs.com
Hands up if you love chromatin & structural biology 🙋♂️ On Friday April 24th we will be joined by @kjarmache.bsky.social from NYU for his webinar 'Chromatin-Modifying Complexes in Gene Activation and Silencing'. Register here: us06web.zoom.us/webinar/regi... @activemotifusa.bsky.social
We are excited to be recruiting into 3 Associate Professorship's in @oxfordbiochemistry.bsky.social. Come join us as a colleague and benefit from our vibrant and multidisciplinary environment. Reach out to me if you have any questions. Please repost! (tinyurl.com/48deybuu) (tinyurl.com/4pdvjaft).
Are you a structural biologist pushing the boundaries of molecular science with an ambitious research programme? Join our Structural Studies Division as a tenure-track Group Leader, with core funding, world-leading facilities & enthusiastic colleagues. Apply by 16 MAR www.nature.com/naturecareer...
Very cool story! Congrats Lluis and team
Lluis Morey@lluismorey.bsky.social · 6mo agoVery excited to share our new Molecular Cell paper on missense mutations in Polycomb genes and how they can disrupt chromatin regulation to drive neurodevelopmental disorders. A huge thank you to everyone involved, and to our amazing collaborators! www.cell.com/molecular-ce...
MECHANISMS, EPIGENETICS, CHROMATIN and DISEASE! Amazing speakers, fun organizers (@ckadoch.bsky.social and I) and excellent venue! Just ~1 month until our Keystone Symposia on Epigenetics and Gene Regulation in Health and Disease! Join us! www.keystonesymposia.org/conferences/...
Congrats JP, Mike and Jess and colleagues on the paper. Very interesting work.
Jean-Paul Armache@valendraica.bsky.social · 7mo agoA wonderful collaboration between Jess Tyler lab, @epicypher.bsky.social, @gcloner.bsky.social, James Kadonaga and our lab at PSU. In this article, we provide the significance of the nucleosome acidic patch. doi.org/10.64898/202...
Last chance to save $250! Register by Jan. 6 (11:59 pm MST) for the Keystone Symposium Epigenetics & Gene Regulation in Health and Disease. Hear from organizers @kjarmache.bsky.social & @ckadoch.bsky.social 🎥 youtu.be/sLfyuQuH8F0 🔗 hubs.la/Q03ZfFF80 #KSEpigenetics26 #Epigenetics #GeneRegulation
KSQA: Dr Karim-Jean Armache / Dr. Cigall Kadoch (Epigenetics and Gene Regulation)
YouTube video by KeystoneSymposia
youtu.be
⏰ Deadline Nov 4 (11:59pm MDT)! Submit your short talk abstract or scholarship app for Epigenetics & Gene Regulation in Health & Disease (Feb 15–18, 2026, Santa Fe). Join @kjarmache.bsky.social & @ckadoch.bsky.social ! 🎥 youtu.be/sLfyuQuH8F0 keysym.us/KSEpigenetic... #KSEpigenetics26
KSQA: Dr Karim-Jean Armache / Dr. Cigall Kadoch (Epigenetics and Gene Regulation)
YouTube video by KeystoneSymposia
youtu.be
@ckadoch.bsky.social and I are excited to welcome you to Geneva for the 2026 Keystone Symposium on Epigenetics and Gene Regulation in Health and Disease — short talk and poster slots are still open. Don’t miss the deadlines. Video: youtu.be/sLfyuQuH8F0
KSQA: Dr Karim-Jean Armache / Dr. Cigall Kadoch (Epigenetics and Gene Regulation)
YouTube video by KeystoneSymposia
youtu.be
Come join us in Geneva for everything epigenetics and gene regulation. It will be a great meeting! Please repost! www.keystonesymposia.org/conferences/...
Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities | Keystone Symposia
Join us at the Keystone Symposia on Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities, March 2026, in Geneva, with field leaders!
keystonesymposia.org
Honored to be named the Laura and Isaac Perlmutter Endowed Chair in Biochemistry at NYU Grossman School of Medicine. Grateful to my mentors, lab members, and the NYU community—and most of all, to my amazing family for their constant support!
This will be *the* place to be to hear about hot-off-the-press new findings from academic and industry leaders, bridging basic chromatin and gene regulatory mechanisms with new precision medicine approaches! Don’t miss it!! @kjarmache.bsky.social and I are looking forward to welcoming you!
Karim-Jean Armache@kjarmache.bsky.social · 10mo agoJoin us in Geneva (March, 2026) for the Keystone Symposium Epigenetics & Gene Regulation in Health and Disease, co-organized with @ckadoch.bsky.social — linking epigenetic mechanisms with therapeutic innovation. Apply for a short talk! #KSEpigenetics26 #epigenetics #chromatin #KeystoneSymposia
Join us in Geneva (March, 2026) for the Keystone Symposium Epigenetics & Gene Regulation in Health and Disease, co-organized with @ckadoch.bsky.social — linking epigenetic mechanisms with therapeutic innovation. Apply for a short talk! #KSEpigenetics26 #epigenetics #chromatin #KeystoneSymposia
Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities | Keystone Symposia
Join us at the Keystone Symposia on Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities, March 2026, in Geneva, with field leaders!
keysym.us
Our Department is recruiting as well. As a public institution we can’t afford professional quality videos so this post will have to suffice😱.
The Francis Crick Institute@crick.ac.uk · 10mo agoWe're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions. Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research. Apply now ➡️ www.crick.ac.uk/careers-stud...
The Emerging Leader Award program “lets people follow where the science goes,” says 2019 winner Andrew Lane. That flexibility has allowed him to bring discoveries from bench to bedside with impressive speed. Learn more in our 2024 Annual Report: 2024.themarkfoundation.org/an-emerging-...
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions. Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research. Apply now ➡️ www.crick.ac.uk/careers-stud...
On behalf of @ckadoch.bsky.social and myself, we are pleased to present our upcoming @KeystoneSymposia, #KSEpigenetics26 Epigenetics and Gene Regulation in Health and Disease, March 2-5, in Geneva, Switzerland. keysym.us/KSEpigenetic...
Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities | Keystone Symposia
Join us at the Keystone Symposia on Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities, March 2026, in Geneva, with field leaders!
keysym.us
2nd Meeting on Epigenetics & Epigenomics - 24th - 26th September, Brussels 🇧🇪 Speakers Line-up looks fantastic including @adelmanlab.bsky.social @kjarmache.bsky.social @mariekeoudelaar.bsky.social @tinekelenstra.bsky.social @lucianodicroce.bsky.social www.xcellsconferences.com/epigenetics2...
Epigenetics 2025 | Xcells Conferences
xcellsconferences.com
As the incoming Chair of Biochemistry and Biophysics at Weill Cornell Medicine, I am looking for a Director of Research. Exciting opportunity for a PhD scientist to shape the future of this new Department! Apply here: jobs.weill.cornell.edu/NY/job/New-Y...
Director of Research, Biochemistry & Biophysics
Director of Research, Biochemistry & Biophysics
jobs.weill.cornell.edu
Excited for this summer’s NYC Chromatin Club! Grad students & postdocs: submit your abstracts for a chance to present a poster or talk. Come connect w/ fellow epigenetic New Yorkers! #NYCChromatinClub @dshechter.bsky.social @vivrisca.bsky.social @epicypher.bsky.social @kjarmache.bsky.social
Great work! Congrats Anja and colleagues!
The Groth lab@grothlab.bsky.social · last yr.𝐇𝐨𝐰 𝐝𝐨 𝐜𝐞𝐥𝐥𝐬 𝐫𝐞𝐦𝐞𝐦𝐛𝐞𝐫 𝐰𝐡𝐨 𝐭𝐡𝐞𝐲 𝐚𝐫𝐞 𝐚𝐟𝐭𝐞𝐫 𝐃𝐍𝐀 𝐫𝐞𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧? Our new study “Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability” is out in 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘴. Led by @lleonie.bsky.social @biranalva.bsky.social 🧵 More below👇
Structural biology of native transcription complexes! Congrats JP and team!
Jean-Paul Armache@valendraica.bsky.social · last yr.We did a thing... We purified native transcriptional complexes from Drosophila embryos, obtaining +/- stalk Pol II elongation complexes, native nucleosomes, as well as a nucleosome elongation complex. For more details please check out: doi.org/10.1101/2025...
Congratulations to all authors on this very interesting work! Regarding EZH1, it aligns well with what our group and Danny Reinberg's group have proposed based on structural and functional data.
Adrian Bracken@adrianbracken.bsky.social · 2y agoPlease see 🧵by @evhealy.bsky.social about our new paper exploring the role of PRC1 and PRC2 in non-dividing cells 👇
Congrats Ale, Zawar and colleagues! This is great work.
Alessandro Vannini@alessandrovannini.bsky.social · 2y agoExcited to share the (hard) work of @zawarshah.bsky.social in its final form: www.nature.com/articles/s41... A lot of insights into RNA Polymerase selectivity at snRNAs promoters !! As these promoters are often used for heterologous expression of RNAs (ie guide RNAs), you better know how they work
Please see our paper in Nature on read-write mechanisms of H2AK119 ubiquitination by Polycomb repressive complex I. Congrats to the whole team, especially Victoria and huge thanks to our collaborator JP Armache! Also big thanks to Mark Foundation for Cancer Research for the support! rdcu.be/dZ5HZ
Read–write mechanisms of H2A ubiquitination by Polycomb repressive complex 1
Nature - Cryo-electron microscopy and biochemical studies elucidate the read–write mechanisms of non-canonical PRC1-containing RYBP in histone H2A lysine 119 monoubiquitination and their...
rdcu.be
Well done! Congrats Rob and colleagues.
Rob Klose@robklose.bsky.social · 2y agoHere it is! Congratuations to @jesskelley.bsky.social @edimitrova.bsky.social @neilblackledge.bsky.social @aleksszczurek.bsky.social and the rest of the team (Maciej, Amy, and Hieu). This was a fab collaboration with Arminja Kettenbach. Also see a lovely complementary paper from Fei Chen's group.
This paper marks our trilogy on H2AK119Ub mechanisms. We have now characterized: PRC1 (the Writer), BAP1/ASXL1 (the Eraser) and DNMT3A1 (the Reader) of H2AK119Ub in collaboration with the amazing labs of Chao Lu, JP Armache, Diego Pasini, Mike Keogh and the Epicypher and Evgeny Nudler.
