Emilia Dimitrova
@edimitrova.bsky.social
Scientist interested in chromatin and regulation of transcription. Klose lab, University of Oxford
(1/9) Excited to share my preprint on Polycomb 3D chromatin interactions from my postdoc with @andersshansen.bsky.social! We were surprised to find that canonical PRC1 doesn't seem to be the only contributor to these interactions: www.biorxiv.org/content/10.6...
Great to see this work @mileshuseyin.bsky.social out. Enjoyed seeing some of the data when he visited our lab, looking forward to digging in the details
bioRxiv Genomics@biorxiv-genomic.bsky.social · 2w agoDissection of Polycomb complexes reveals canonical PRC1-independent 3D chromatin interactions https://www.biorxiv.org/content/10.64898/2026.10.13.758654v1
Very proud of this study! Two fundamental processes in gene expression turn out less tightly connected than thought. And their relationship may help explain some surprising vulnerabilities of cancer cells. A big thank you to Agata and Deepshika for years of hard work, and kudos to all collaborators!
Agata Stepien@agatakstepien.bsky.social · 2w agoTwo steps in gene expression that should move together… don’t. In our new paper we show that pre-mRNA cleavage and RNA polymerase II (RNAPII) termination shift in opposite directions – with a surprising link to gene expression and cancer cell vulnerability. Read more here: tinyurl.com/3pkeuctp
Dr. Amanda Fisher from the University of Oxford will be presenting groundbreaking research for this year’s P01 Symposium! Save your spot today: nyulangone.zoom.us/webinar/regi... #chromatin2026
We are all looking forward to Adele joining us! Stayed tuned, more exciting announcements soon!
Oxford Biochemistry @oxfordbiochemistry.bsky.social · 3w agoFantastic news that Adele Marston will join us in 2027 as Professor of Molecular and Cellular Biochemistry at the University of Oxford. 🎉 🎉 🎉 Read the full story 👇 bit.ly/marston_10_26
Great session next week! Not to be missed! @paul-villain.bsky.social from our neighbouring lab has a fantastic story
FragileNucleosome@fnucleosome.bsky.social · 4w ago📢🧬Join us on Wednesday, Oct 7th for the next #FragileNucleosome seminar to hear exciting chromatin stories from Moonmoon and Paul! If you still haven't registered for our series: us06web.zoom.us/webinar/regi...
On of my favourite meetings! Great opportunity to learn about UK-based science! Lovely to see @oxfordbiochemistry.bsky.social being well represented this year. Also - 3 Klose lab alumni! Gutted that I don't think I can make it to York this time!
Biochemical Society@biochemsoc.bsky.social · last mo.What’s next in transcription and chromatin biology? Find out in York, 18–20 November, as researchers come together to share the latest breakthroughs in epigenetics, genome organisation and transcriptional regulation. Book your place. https://www.eventsforce.net/biochemsoc/286/register
I really enjoyed chatting with Stefan at the recent EMBO transcription and chromatin meeting about some of my thoughts on CpG island biology!
Epigenetics Podcast@epigeneticspod.bsky.social · last mo.In this episode we speak with @robklose.bsky.social, Professor of Genetics at the University of Oxford, about how CpG islands help control gene expression and chromatin regulation during development. #podcast #epigenetics Listen here: activemotif.com/podcasts-rob...
Deadline fast approaching for the Transcription and Chromatin UK meeting - 18-20 November 2026. Submit your abstract for this exciting meeting by tomorrow for a chance to present. Hope to see you in York! 🧬
Lorraine Reese@lorraine-reese.bsky.social · 2mo agoTranscription and Chromatin UK brings together the rich transcription and epigenetics community in the UK and leading experts from abroad. Most talks will be selected from abstracts and interspersed with invited speaker presentations, submit your abstract before 18 Sept! 🧪 bit.ly/4eWyTmc
Excited to share our new preprint on in situ chromatin structure of the inactive X chromosome in differentiated female mouse embryonic stem cells. www.biorxiv.org/content/10.6... 🧵1/8
📣 Interested in non-coding disease-causing variants? Check out our review "Mechanisms underlying disease-causing variants in promoters and enhancers". Interesting mechanisms, challenges and future perspectives. Great to work with @wbickmor.bsky.social, Kun and Ryan! www.nature.com/articles/s41...
Mechanisms underlying disease-causing variants in promoters and enhancers - Nature Genetics
This Review discusses how rare-disease-causing variants in the noncoding genome impact gene regulation, why these examples are so few and how new approaches could accelerate discovery of noncoding var...
nature.com
Wendy Bickmore@wbickmor.bsky.social · 2mo agoIt was great working with students Kun and Ryan and @hannahlong.bsky.social, combing the literature to try and find examples of bona fide disease-causing variants in non-coding elements - promoters, enhancers and silencers. www.nature.com/articles/s41...
🎤 #FragileNucleosome is back next Wednesday! Hope you enjoyed the summer!Join us next 📅Wednesday to hear about 🧬fascinating research from @mpalamin.bsky.social from Krebs lab and @robertovn.bsky.social from Vos lab. To register if you haven't before: us06web.zoom.us/webinar/regi...
Delighted to finally share the preprint on this crazy project! Deleting all the major NAPs of E. coli is viable. The strain, while fragile, grows surprisingly well. But, what happens with transcription, genome compaction, genome organisation...? Find out here: www.biorxiv.org/content/10.6...
Chromatin is dispensable for bacterial life
Inside cells, DNA is intimately associated with proteins, forming chromatin. The protein constituents of chromatin vary across the tree of life: histones are the principal building blocks of chromatin...
biorxiv.org
Tobias Warnecke@tobiaswarnecke.bsky.social · 2mo agoWho needs chromatin anyway...? NOT THIS GUY! www.biorxiv.org/content/10.6... 1/n
@mileshuseyin.bsky.social and the lab have put together a comprehensive protocol for genome-wide Micro-C and for Region-Capture Micro-C in @natprot.nature.com : www.nature.com/articles/s41... See also the GitHub for a user-friendly end-to-end computational pipeline: github.com/ahansenlab/M...
Nature Protocols@natprot.nature.com · 4mo agoNew Article! Mapping 3D genome organization at nucleosome-scale with Micro-C and Region Capture Micro-C (RCMC)
Amazing new method for live-cell imaging of RNA molecules developed by Adam in the Brockdorff lab! Worth having a look at!
bioRxivpreprint@biorxivpreprint.bsky.social · 4mo agoNuclear-BRITE: an enhanced MS2 system for live-cell imaging of nuclear RNAs https://www.biorxiv.org/content/10.64898/2026.07.07.736975v1
Does every enhancer work with every promoter? With @jengreitz.bsky.social and Will Greenleaf, we revisit this long-debated question and resolve an outstanding contradiction in the field. A tour 🧵👇 www.biorxiv.org/content/10.6...
Intrinsic promoter responsiveness dictates sensitivity to transcriptional activation by enhancers
Enhancers activate specific target promoters, but whether intrinsic enhancer-promoter compatibility contributes to this specificity is debated. Recent studies using different reporter assays have reac...
biorxiv.org
"the first validated, large-scale framework for judging the quality of life science papers independently of venue, identity, and prestige...Blinded domain-expert professors sided with score three times more often than with journal rank" the-one-percent.qedscience.com 1/n
QED — The most compelling preprints of 2025
the-one-percent.qedscience.com
Gloves are off! TODAY WE RELEASE THE 1% A list of the year’s very best papers 👇 (see thread)
Best news on such a hot day! Congratulations @au-ho-yu.bsky.social and @robklose.bsky.social - an amazing achievement! Alan has done an amazing job and is currently working hard to address the reviewers' concerns! Comments came took 4 months to come back - reviewer 2 doesn't agree with g.e.d!
QED Science@qedscience.bsky.social · 4mo ago🎉 Meet The 1%. Out of 57,455 bioRxiv life science preprints, QED Science selected 574 exceptional manuscripts through blind evaluation. The 1%: the-one-percent.qedscience.com Good science deserves to be seen. @biorxivpreprint.bsky.social @openrxiv.bsky.social @richardsever.bsky.social
We looked at 57,455 preprints. No names. No institutions. No reputations. Just the science❕ In 48 hours, we reveal The 1%. #The1Percent #QEDScience #Preprints
This study led by @flavia-con.bsky.social from the Brockdorff lab is finally published at Nature Communications! www.nature.com/articles/s41... Using live-cell and single-molecule imaging, this work dissects how the epigenetic regulator #SMCHD1 interacts with chromatin during X-inactivation.
Selective interaction of SMCHD1 with chromatin is governed by LRIF1 and SMCHD1 ATPase activity - Nature Communications
SMCHD1 is a key player in X chromosome inactivation in mammals and has been linked to two human disorders. Here, the authors present insight into SMCHD1’s mode of interaction and functionality at its ...
nature.com
Guifeng Wei@guifengwei.bsky.social · last yr.Fresh preprint by @flavia-con.bsky.social from our lab uncovers how SMCHD1 finds & binds chromatin using live-cell single-molecule imaging🔬 She reveals how SMCHD1 dynamically engages chromatin, including the inactive X chromosome, to maintain gene silencing. www.biorxiv.org/content/10.1...
Yaay! Well done @bluebuleta.bsky.social and team! Great to see this work finally out! Read the paper to see how SETDB1 and HUSH regulate Xist transcription
Mafalda Almeida 🇵🇹 🇪🇺 🇬🇧@bluebuleta.bsky.social · 5mo ago🧵 Happy to share that the final version of our study is finally out in @natcomms.nature.com today: www.nature.com/articles/s41... What started as an unexpected observation—that SETDB1 depletion accelerates X chromosome silencing—led us to uncover a role for SETDB1 in regulating Xist transcription.
Unacceptable! Have people started asking for refunds? We don't use Thermo antibodies much but have a couple in the freezer (one I have to admit is good!)
Reese Richardson@reeserichardson.bsky.social · 5mo agoThermo Fisher now has a page up in response to our observations. They flatly deny that images were manipulated or fabricated while repeating that images were "optimized for presentation and clarity on the website", no lie, six times. www.thermofisher.com/us/en/home/l...
Help please! We need to do some large(ish) cell culture inhibiting E-cadherin with a monoclonal antibody. Does anyone have the DECMA-1 hybridoma cell line so we could purify our own antibody? or a similar monoclonal that would do the job. Any help greatly appreciated, just DM me. Please repost!
Congratulations @robklose.bsky.social for being elected as a Fellow of the Royal Society! royalsociety.org/news/2026/05... great news to have two outstanding scientists, Rob and Colin, from @oxfordbiochemistry.bsky.social joining the Royal society today!
Exceptional scientists elected as Fellows of the Royal Society | Royal Society
Over 90 outstanding researchers from across the world have this year been elected to the Fellowship of the Royal Society, the UK’s national academy of sciences.
royalsociety.org
Today we celebrate our colleagues Colin Kleanthous and Rob Klose as they join the Fellowship of the Royal Society, one of the highest honours in the scientific world, in recognition of their impactful contributions to knowledge. Congratulations! 👏 👏 👏 Read more ⬇️
Congratulations to Colin Kleanthous and Rob Klose on joining the Fellowship of the Royal Society
The two scientists have been selected for outstanding contributions to their fields
bit.ly
Happy 100th birthday, Sir David Attenborough! 🎂 A legendary broadcaster, natural historian and Clare College alumnus whose voice has inspired generations worldwide for decades. Thank you for a century of curiosity, wonder and unwavering dedication to life on earth.
Very importantly, one of the co-organisers @xrnchew.bsky.social is cycling to the meeting to raise awareness and funds for 'All things small and green' . Please join him or sponsor him! gofund.me/f4068dc3c
Donate to Cycling from Exeter to the 3' end (in Oxford)!, organized by Steven West
I'll be cycling from Exeter to Oxford (about 160 miles/260 km) - hopefully … Steven West needs your support for Cycling from Exeter to the 3' end (in Oxford)!
gofund.me