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Karl Romanowicz

@kroman.bsky.social

Principal Scientist @synplexity.bsky.social Synthetic Biology and Bioinformatics

3 Posts268 Follower802 Folgt
Calin Plesa@calin.bsky.social · 6mo ago

New lab preprint: if ML struggles with extrapolation, let's expand the diversity of training data with gene synth, DNA shuffling, and ML gen.... also lots of #FluorescentProteins #ProteinEngineering #MachineLearning #SyntheticBiology 1/n

bioRxiv Synthetic Biology@biorxiv-synthbio.bsky.social · 6mo ago

High Diversity Gene Libraries Facilitate Machine Learning Guided Exploration of Fluorescent Protein Sequence Space https://www.biorxiv.org/content/10.64898/2026.03.01.706892v1

Karl Romanowicz@kroman.bsky.social · last yr.

Our new Science Advances paper is out! 🎉 The Plesa Lab's first, it builds on DropSynth technology as a proof of concept for large-scale synthetic gene libraries, showcasing a synthetic metagenomics approach to studying antibiotic resistance at scale. 👉 www.science.org/doi/10.1126/...

Exploring antibiotic resistance in diverse homologs of the dihydrofolate reductase protein family through broad mutational scanning

DropSynth technology enables scalable and cost-effective exploration of antibiotic resistance across the DHFR protein family.

science.org

Karl Romanowicz@kroman.bsky.social · 2y ago

Permafrost thaw takes center stage on Ice & Fire Climate Change podcast! 🎙️❄️🔥 S2 Ep2 "Layer" & Ep3 "Microbes Reawaken" explore carbon release & climate impacts. Hear my research! Tune in: iceandfireclimatepodcast.weebly.com/s2-permafros... #ClimateChange #PermafrostResearch #SciComm

s2: permafrost thaw

podcast is available for listening on Apple Podcasts, Spotify, Overcast, and through the Public Radio Exchange (PRX) ​ ​ or listen below. Press "More Info" in each episode player to reveal show...

iceandfireclimatepodcast.weebly.com