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Paul Kristian LaFosse

@lafosse.bsky.social

Postdoc @ HHMI Janelia w/ Pachitariu + Stringer Lab. Former PhD at NIH/UMD. 🧠⚡

8 Posts129 Follower162 Folgt
Mark Histed@markhisted.org · 5mo ago

My travel to Cosyne was barred by the Trump admin, so I'm here on my personal dime. I care about the COSYNE community, I committed to co-chairing. And I always learn here. But the worst part about this travel ban is my lab colleagues— students and fellows—couldn't come. /1

Mark Histed@markhisted.org · 9mo ago

Our lab had a poster at the #SFN2025 meeting in San Diego, but the #NIH people were not able to attend. I wanted to call in Haleigh Mulholland, postdoctoral fellow (2nd pic). Haleigh was a major driver behind this project, and I encourage anyone with questions to reach out to her. /1

Search Results Print Page Share Page Session PSTR025 - Visual System: Plasticity and Repair PSTR025.14 / K8 - Pattern-specific plasticity in visual cortex is gated by acetylcholine Add to Itinerary November 15, 2025, 1:00 PM - 5:00 PM SDCC Halls B-H Presenter at Poster Sat., Nov. 15, 2025 2 - 3:00 p.m. Session Type Poster Grant Support NIH BRAIN Initiative Grant U19NS107464 Grant Support NIMH Intramural Research Program ZIAMH0020967 Citation *P. K. LAFOSSE1, H. N. MULHOLLAND2, Z. ZHOU2, M. H. HISTED2; 1Janelia / HHMI, Ashburn, VA; 2Natl. Inst. of Mental Hlth., NIH / NIMH, Bethesda, MD. Pattern-specific plasticity in visual cortex is gated by acetylcholine. Program No. PSTR025.14. 2025 Neuroscience Meeting Planner. San Diego, CA. : Society for Neuroscience, 2025. Online. Authors *P. K. LAFOSSE1, H. N. MULHOLLAND2, Z. ZHOU2, M. H. HISTED2; 1Janelia / HHMI, Ashburn, VA; 2Natl. Inst. of Mental Hlth., NIH / NIMH, Bethesda, MD Disclosures P.K. LaFosse: None. H.N. Mulholland: None. Z. Zhou: None. M.H. Histed: None. Abstract To navigate the world, animals must readily adapt to new sensory information. In the cortex, this information is represented as dynamic patterns of activity across networks of neurons, which are refined with learning. The classic Hebbian theory of learning posits that coactivated neurons become functionally coupled via synaptic strengthening, possibly enabling network computations useful for behavior such as pattern amplification. However, recent work shows that photostimulation of neurons alone without behavioral engagement is not sufficient to induce plasticity (Akitake, Douglas et al., 2023), suggesting plasticity may require both neuronal coactivation and neuromodulatory signals. Acetylcholine (ACh), involved in arousal and attention and broadly released throughout the cortex, plays an important role in learning and may gate this form of behavior-dependent plasticity in neural circuits (Gold, 2003; Kang et al., 2014). To test this, we aimed to …Haleigh Mulholland, was not able to attendPaul LaFosse, presented at SFN 2025
Mark Histed@markhisted.org · 9mo ago

Sigh. NIH normally sends several hundred scientists to the SFN annual meeting to learn, exchange info, come up with new ideas, and advance science. (The exchange of ideas is the very core of the scientific enterprise.) This year, no one from NIH will attend due to the gov't implosion.

Society for Neuroscience@sfn.org · 9mo ago

Enjoy a broad range of lectures and network with experts in the field at #SfN25! 🧠 Gain valuable insights and tools to enhance your research and career. Browse through to lectures and build your itinerary in the 2025 Neuroscience Meeting Planner 🔗 vist.ly/4de72 #neurosky #neuroskyence

Mark Histed@markhisted.org · 10mo ago

The brain is incredibly densely connected. Human cerebral cortex may have as many as *one trillion* connections. Most of those cortical connections are recurrent, inside each area. What do they do? New paper from me in Annual Reviews: 🧪 🧠📈 1/ www.annualreviews.org/content/jour...

Active Filtering: A Predictive Function of Recurrent Circuits of Sensory Cortex | Annual Reviews

Our brains encode many features of the sensory world into memories: We can sing along with songs we have heard before, interpret spoken and written language composed of words we have learned, and reco...

annualreviews.org