Carsen Stringer

@computingnature.bsky.social

group leader @ HHMIJanelia, #neuroscience + AI ๐Ÿ”ฌ #cellpose | diversity and open-science for better science | she/her | https://mouseland.github.io

๐Ÿ“ฃNew paper! How does the sleeping brain help us to integrate new experiences while managing memories from the past? For his PhD work, @sabbaspoor.bsky.social recorded hippocampal ensembles in freely moving monkeys and found something unexpected. ๐Ÿงต1/n www.nature.com/articles/s41... ๐Ÿงช๐Ÿง ๐Ÿ“ˆ๐Ÿ‘ฉโ€๐Ÿ”ฌ#OpenAccess

Experience reorganizes content-specific memory traces in macaques - Nature Neuroscience

In macaques, old memories, relative to new ones, are supported by more stable and interconnected cell assemblies. New-biased and old-biased assemblies reactivate during overnight sleep and can sometim...

nature.com

We used these reporters to image developing zebrafish peripheral nerves at high resolution over time. Here is a rendering of a myelinated sensory nerve (the posterior lateral line): myelin in green, with nfasca/NF186 marking nodes of Ranvier in magenta

we've been doing this too but more as performance art to see what we can get the bots to do. so far the answer is "anything" github.com/dwebagents/A... i think my favorite is the PR whose only text was "butter" which got us the butter mode page: dwebagents.github.io/AgentPipe/bu...

Issue in dwebagents/AgentPipe number 1878 by drewcassidy

title: [bounty: butter] butter

body: butter[PR by Votienduang2208 in response to the butter PR]

Title: Yes chef. Right away chef. Add Butter Mode

Body:

Yes chef. Right away chef.

Fixes #1878.
Summary

    Adds a new static docs/butter.html page for the butter bounty.
    Implements a self-contained Butter Mode experience with an animated butter mascot, 71% default spread meter, lifecycle states (spread, churn, melt, clarify), and interactive controls.
    Links the butter page from the docs home navigation.
    Adds npm run test:butter with static acceptance checks for the page, script, navigation link, and smoke-test API.[A website that looks exactly the same as all other LLM websites - titled "butter mode" with a stick of butter that gently rocks back and forth.]

Issue #1878: butter
Butter Mode

AgentPipe now has a dedicated butter ritual: spread, churn, melt, and clarify task throughput until the pipeline glides like warm toast. 


71%
default spread coverage for compliant toast surfaces.

0 crumbs
no needless runtime dependencies; this is static and shelf-stable.

4 states
spread, churn, melt, and clarify โ€” the complete butter lifecycle. 

[A butter controls slider controls the amount of butter spread, among a few other operations like churn, melt, and clarify]
Andras Bacsai@heyandras.dev ยท 3mo ago

We made a fake repo with fake bounties, and the bots are applying fake PRs, so we know who is fake, and we can ban them from the Coolify repo. IQ over 1000

PHASE ONE of our fight against the OMB rule is complete and YOU ALL SHOWED UP!!! HALF A MILLION COMMENTS is WILD. We absolutely exceeded our goal of 100,000! So, what happens next??? Welcome to PHASE TWO: Pressure and Preparation! 1/x

Our Impact Scholars @neuromatch.bsky.social project on ๐—ต๐—ผ๐˜„ ๐—ฟ๐—ฒ๐˜„๐—ฎ๐—ฟ๐—ฑ ๐˜ƒ๐˜€ ๐—ฒ๐˜…๐—ฝ๐—ฒ๐—ฟ๐—ถ๐—ฒ๐—ป๐—ฐ๐—ฒ ๐˜€๐—ต๐—ฎ๐—ฝ๐—ฒ ๐—ป๐—ฒ๐˜‚๐—ฟ๐—ฎ๐—น ๐—ฝ๐—ผ๐—ฝ๐˜‚๐—น๐—ฎ๐˜๐—ถ๐—ผ๐—ป ๐—ฑ๐˜†๐—ป๐—ฎ๐—บ๐—ถ๐—ฐ๐˜€ ๐—ถ๐—ป ๐—บ๐—ผ๐˜‚๐˜€๐—ฒ ๐˜ƒ๐—ถ๐˜€๐˜‚๐—ฎ๐—น ๐—ฐ๐—ผ๐—ฟ๐˜๐—ฒ๐˜… is out! โ€จ With ๐—๐—ผ๐—ต๐—ป ๐— ๐—ฎ๐—ฑ๐—ฟ๐—ถ๐—ฑ-๐—–๐—ฎ๐—ฟ๐˜ƒ๐—ฎ๐—ท๐—ฎ๐—น @johnmadridcarvajal.bsky.social, ๐—ž๐—ฎ๐˜๐—ท๐—ฎ ๐—ž๐—ฎ๐˜‚๐—ฟ๐—ถ๐—ป๐—ธ๐—ผ๐˜€๐—ธ๐—ถ, ๐—œ๐˜€๐—ต๐—ฎ๐˜๐—ฝ๐—ฟ๐—ฒ๐—ฒ๐˜ ๐—ฆ๐—ถ๐—ป๐—ด๐—ต, ๐—ฅ๐—ผ๐—ต๐—ถ๐˜ ๐—๐—ฒ๐˜€๐˜„๐—ฎ๐—ป๐˜๐—ต. ๐Ÿง  ๐Ÿ‘‰ zenodo.org/records/2064... ๐Ÿงต๐Ÿ‘‡ 1/8

Schematic of the experimental setup and our analysis. Mice experienced visual corridors containing leaf or circle patterns, with reward available only for one pattern in the rewarded cohort and no reward in the unrewarded cohort. Large-scale calcium imaging sampled neurons across V1 and higher visual areas before and after learning. Neural activity was organised into neuron ร— time ร— trial tensors and analysed with tensor component analysis. Example factors show differences between rewarded and unrewarded mice before versus after learning, including stronger separation of leaf and circle trials after rewarded learning.

๐Ÿšจ HEADS UP: If you haven't submitted a comment on the OMB proposal yet, there's still time - but it's running out! There are only 11 days left to push back against Russell Vought's attempt to give political appointees unprecedented control over federal research funding. Take Action: zurl.co/R83IO

Graphic from Stand Up for Science urging action on a federal funding proposal. Large text reads: "11 Days Left" and "Help Us Stop Vought From Destroying American Science." A portrait of Russell Vought appears beside the U.S. Capitol. A banner along the bottom reads: "Submit a comment on the OMB proposal | Link in bio to take action." The Stand Up for Science logo appears in the top left.