Congratulations @robinmagnard.bsky.social @daiannaglez.bsky.social and everyone involved from @kr-maynard.bsky.social @triciajanak.bsky.social @lcolladotor.bsky.social teams! Excited to see you all get this paper published and excited for the next steps and follow up studies!

Robin Magnard@robinmagnard.bsky.social · 7d ago

🧠🧬 What are the effects of intravenous fentanyl self-administration on the habenula and amygdala transcriptomes? In our new Addiction Biology paper, we addressed this question using a chronic long-access model in rats! Here are some highlights 🧵👇 Paper 👉 dx.doi.org/10.1111/adb....

I am so thrilled to share that i was selected to received the 2026 BBRF young investigator grant from the @bbrfoundation.bsky.social. This is meaningful for me. Thanks so much to @martinowk.bsky.social and the @lieberinstitute.bsky.social for all the support.

The dataset is openly shared and available for download here 👇 github.com/LieberInstit...

GitHub - LieberInstitute/fentanyl_rat_hb_amy

Contribute to LieberInstitute/fentanyl_rat_hb_amy development by creating an account on GitHub.

github.com

It was great working with @daiannaglez.bsky.social on this study! This is the first paper from a collaboration between @triciajanak.bsky.social, @lcolladotor.bsky.social and @kr-maynard.bsky.social labs! Stay tuned for our single-cell profiling follow-up in both males and females!

Integration with existing rodent and human single-cell datasets linked these changes to specific neuronal, glial and vascular cell types. In the amygdala, upregulated genes overlapped with schizophrenia risk genes, while downregulated genes were enriched for substance use disorder risk genes.

Bulk RNA-seq found 453 differentially expressed genes in the habenula and 3,041 in the amygdala. Upregulated genes: synaptic transmission and ion conductance in the habenula; metabolic and vesicular functions in the amygdala. Downregulated genes: extracellular matrix functions in both regions.

🧠🧬 What are the effects of intravenous fentanyl self-administration on the habenula and amygdala transcriptomes? In our new Addiction Biology paper, we addressed this question using a chronic long-access model in rats! Here are some highlights 🧵👇 Paper 👉 dx.doi.org/10.1111/adb....

Transcriptional Response to Chronic Long‐Access Fentanyl Self‐Administration in Rat Habenula and Amygdala

Chronic intravenous long-access fentanyl self-administration in rats produced transcriptional remodeling in the habenula and amygdala. Bulk RNA-sequencing identified 453 habenula and 3,041 amygdala d...

dx.doi.org

Was HOT 🌞 yesterday for long standing @lieberinstitute.bsky.social annual 🦀 feast tradition. Thanks to everyone on our teams who came out to celebrate another year of accomplishments, community and great science!

(1/10) We’re excited to share our recently published study www.sciencedirect.com/science/arti... which uncovers the spatiomolecular landscape of the human NAc, a key reward structure by integrating snRNA-seq with Visium spatial transcriptomics. 🧠 #NAcLIBD #snRNAseq #10xVisium

Spatiomolecular mapping reveals anatomical organization of heterogeneous cell types in the human nucleus accumbens

The nucleus accumbens (NAc) is a key component of the mesolimbic dopamine system that is implicated in several neuropsychiatric disorders. The NAc con…

sciencedirect.com

Excited to share our new study characterizing spatial gene expression in the human NAc led by @prashanthi-ravi.bsky.social @svitlanabach.bsky.social @rphillips3.bsky.social in collaboration with @martinowk.bsky.social @stephaniehicks.bsky.social @alexisbattle.bsky.social @lcolladotor.bsky.social.

Neuron@cp-neuron.bsky.social · last mo.

Me pregunto si conocen a alguien en #Guatemala 🇬🇹 que trabaje con datos de transcriptómica ( #scRNAseq #RNAseq #SpatialTranscriptomics) y/o use R y en especial #Bioconductor. Para ver si puedo coordinar y a dar una plática por allá. ¡Gracias! #RStats #RStatsES #ARNsec

New team photos! 2026 version with @mbarse.bsky.social, @lahuuki.bsky.social, @nick-eagles.bsky.social ^^. We also have remote member contributors 🗺️ (@daiannaglez.bsky.social, @melo-mq99.bsky.social, @gabrielramirezv.bsky.social, from LCG UNAM). Thank you @martinowk.bsky.social for hosting us!

Thrilled about our new @janaklab.bsky.social paper now out in @npp-journal.bsky.social🧠⚡ Action-sequence termination cues evoke mesolimbic dopamine activity that drives habit-like behavior. Thanks to Tricia Janak, @younavandaele.bsky.social, and @yfcheng.bsky.social! www.nature.com/articles/s41...

Sequence termination cues drive automated habit-like strategy via dopamine-mediated processes - Neuropsychopharmacology

Neuropsychopharmacology - Sequence termination cues drive automated habit-like strategy via dopamine-mediated processes

nature.com

Summary of Key Changes in OMB’s Proposed Federal Financial Assistance Rule. Russell Vought is going destroy American Science. elizabethginexi.substack.com/p/summary-of...

Summary of Key Changes in OMB’s Proposed Federal Financial Assistance Rule

Russell Vought is going destroy American Science

elizabethginexi.substack.com

Si conocen a mexicano/as 🇲🇽 en @jhu.edu (o afiliada/os) y/o profesionistas en Baltimore, avísenme. Organizo un grupo de WA de mexas en Balto que estoy buscando revivir. Voy a aprovechar que estoy organizando una fiesta con mariachis 🎺 🎤 y así intentar fomentar nuestra pequeña comunidad. ¡Gracias!

Schizophrenia’s defining features—perception, thought, cognition—are inseparable from human language and self-awareness. These cannot be reproduced in other animals. Yesterday, in SAO's #WorldSchizophreniaDay article, we celebrated the research that's moving in a different direction. #SCZ #SCZDay

Lots of cognitive dissonance from reading Nature today

It's NIH grant season and I'm talking to a number of researchers with questions about the new DMSP form. Let us briefly marinate in the nonsense. (1/)

✍️ 15 Years of rOpenSci, and We’re Just Getting Started 🎉 by The rOpenSci Team rOpenSci turns 15! 🎉 We're celebrating all year long, starting with three virtual community events on June. Come connect, reflect, and help shape the next 15 years […] [Original post on hachyderm.io]

Reading thank you letters from the kids after doing a Career Day presentation at my kids elementary school, and totally chuffed by some responses: -I think you are 37 -You are so smart, you must make a million dollars -Thanks to you, I'm in love with my brain -You are cool and so is your brain :)

@gpreising.bsky.social is a long read rock star and is looking for postdocs or industry positions! bsky.app/profile/lcol...

🇲🇽 Leonardo Collado-Torres@lcolladotor.bsky.social · 3mo ago

Gabriel @gpreising.bsky.social #LFW shared work involving INECOL & Centro de Investigaciones Científicas de las Huastecas Aguazarca 🇲🇽 They studied swordtail fishes & their alternative reproductive tactics using long read data Earlier work doi.org/10.1093/evol... #BoG2026 @cshlmeetings.bsky.social

Alexis @alexisbattle.bsky.social did an awesome introduction for Jonathan’s @jkpritch.bsky.social for his #BoG2026 keynote! That was reaaaally good! 👏🏽 👏🏽 @cshlmeetings.bsky.social

En #BoG2026 hubo varixs mexicanxs 🇲🇽 o científicxs trabajando con datos de México🇲🇽 Me da gusto 😊 aprender de sus contribuciones a la ciencia. Esta vez hubo proyectos del Mexican Biobank doi.org/10.1038/s415... @cshlmeetings.bsky.social @valenomics.bsky.social Ana @xavierrocarada.bsky.social Irepan

Excited to present a poster at #bog26 this evening starting at 7:30pm! Come by poster #108 to learn about some motivating and preliminary work on a novel method to fine-map causal isoforms in TWAS leveraging tissue-specific long-read RNA-seq evidence.

Shout-out to @seantbres.bsky.social who will be presenting some really interesting work at #bog26 this evening! Using long-read, isoform-resolved placental transcriptomics, this work shows how PFAS exposure impacts placental transcriptional networks and imprinting (poster #70)

Mohamed @mabuelanin.bsky.social included a super cute slide about microtus radiation (referring to new species not ☢️) 🦫🐀 They used #CiFi cifi.dennislab.org which they developed recently. Got chromosome-level scaffolds including several T2T genome 🧬 cases #BoG2026 @cshlmeetings.bsky.social

Arang Rhie from @aphillippy.bsky.social ’s lab told us about there is hidden structural variation on the human acrocentric chromosomes This project benefited from UK Biobank using all hg38 sequences (chrUn_…) More available at doi.org/10.64898/202... #BoG2026 @cshlmeetings.bsky.social

Winston @timp0.bsky.social is guiding us through a #DNAm journey starting with his paper with @kasperdhansen.bsky.social from 2011 Nowadays with @pacbio.bsky.social and @nanoporetech.com long read DNA data you get DNAm for free! 5mC, 5hmC, brain 🧠 etc 🐇 🕳️ #BoG2026 @cshlmeetings.bsky.social

Very interesting! We looked at using perplexity to evaluate quantification estimates in the absence of a ground truth (link.springer.com/article/10.1...). Our inspiration was NLP. I think it's a potentially very useful metric overall.

Perplexity: evaluating transcript abundance estimation in the absence of ground truth - Algorithms for Molecular Biology

Background There has been rapid development of probabilistic models and inference methods for transcript abundance estimation from RNA-seq data. These models aim to accurately estimate transcript-leve...

link.springer.com

Nilah Ioannidis kickstarted #BoG2026 ’s Friday by guiding us through their explorations of how DNA 🧬 sequence prediction models actually perform with unseen sequences Goal: use these models in the clinic for personal genomics to predict individual molecular changes @cshlmeetings.bsky.social