Andras Lakatos @LakatosLab
@lakatoslab.bsky.social
Neurobiologist & Neurologist at Cambridge. My lab focuses on the biology of astrocytes/neurons & develops human organoid disease models to study their role in neurodegeneration and traumatic injuries.
A study in Nature Medicine identified tissue-specific signs of aging and then paired it with transcriptomic data from blood to develop aging clocks that reflect tissue structural integrity and organ-level physiological fitness in health and disease. go.nature.com/4zthv0F #medsky 🧪
Our new collaborative study with Srinjan Basu, led by Alex Kingston, is in preLights!
preLights@prelights.bsky.social · 2mo agoMechanical forces don’t just shape the cortex, they instruct it 🧠 @kanishka03.bsky.social highlights recent work of @alexjkingston.bsky.social & colleagues @lakatoslab.bsky.social @srinjan.bsky.social #preprint #DevBio #preLight ⬇️ prelights.biologists.com/highlights/o...
A human corticospinal organoid-slice connectoid model informs enhancer strategies for post-injury axon regrowth
A human corticospinal organoid-slice connectoid model informs enhancer strategies for post-injury axon regrowth
Gibbons et al. present a human corticospinal organoid slice-based connectoid model, with physically separate but functionally coupled cortical and spinal regions. Allowing cell-type-specific observations, the platform uncovers a developmental maturation-dependent decline in human axon regeneration and a transcriptional program intrinsic to cortical projection neurons that, when targeted, promotes repair post-injury.
dlvr.it
When the #spinalcord is damaged, the resulting #paralysis is usually considered permanent. Now, a new #research approach using lab-grown organoid models led by @lakatoslab.bsky.social from 🇬🇧 @cam.ac.uk suggests that it actually might be reversed.
Lab-grown model shows ‘irreversible’ spinal cord damage may be reversed
Cambridge scientists have grown miniature circuits in the lab that mimic how the brain and spinal cord connect up, which underlies our movements. They used this model to show how damage to these conne...
healthcare-in-europe.com
Congrats to @lakatoslab.bsky.social, @lancasterlab.bsky.social, @sgiando.bsky.social et al. 🏛️ @camneuro.bsky.social, @cneurodept.bsky.social, @pdncambridge.bsky.social, @mrclmb.ac.uk, @scicambridge.bsky.social 💰 @ukri.org 📖 @cp-cellreports.bsky.social www.cell.com/cell-reports...
A human corticospinal organoid-slice connectoid model informs enhancer strategies for post-injury axon regrowth
Gibbons et al. present a human corticospinal organoid slice-based connectoid model, with physically separate but functionally coupled cortical and spinal regions. Allowing cell-type-specific observati...
cell.com
Lab-grown brain-spinal cord model shows ‘irreversible’ nerve damage may be reversed www.cam.ac.uk/research/new...
Lab-grown brain-spinal cord model shows ‘irreversible’ nerve damage may be reversed
Cambridge scientists have grown miniature circuits in the lab that mimic how the brain and spinal cord connect up, which underlies our movements. They used this model to show how damage to these conne...
cam.ac.uk
A human corticospinal organoid-slice connectoid model informs enhancer strategies for post-injury axon regrowth: Cell Reports www.cell.com/cell-reports...
A human corticospinal organoid-slice connectoid model informs enhancer strategies for post-injury axon regrowth
Gibbons et al. present a human corticospinal organoid slice-based connectoid model, with physically separate but functionally coupled cortical and spinal regions. Allowing cell-type-specific observati...
cell.com
Congratulations to George, Andras, @lakatoslab.bsky.social and collaborators for the publication of the human motor axis in dish! As a neurologist, it was amazing to see the corticospinal tract in vitro and how it can reveal new strategies for axon regrowth after injury. www.cell.com/cell-reports...
The first @embo.org #Astrocyte #Meeting was a success! Thanks to our excellent speakers, brilliant trainees, & DiBio @unipd.bsky.social volunteers. Looking forward to the next iteration! Laura.Civiero Matthew.Holt Olga.Sin WonSuk.Chun Keith.Murai Valentin.Nagerl @carmenfalcone.bsky.social
Stem Cell/Organoid/Assembloid session at the UK Dementia Research Institute meeting in Edinburgh - 26-28 March 2025! You can still register here: www.ukdri.ac.uk/events/stem-...
A Postdoctoral Research Associate post is available in the lab in Human Organoid Neurobiology and ALS/MND Research - see our job advert in Nature Careers www.nature.com/naturecareer...
Postdoctoral Research Associate - Cambridge, Cambridgeshire job with University of Cambridge, Department of Clinical Neurosciences | 12834804
A Postdoctoral Research Associate position is available for 2 years in human 3D organoid-based disease modelling in Amyotrophic Lateral Sclerosis (...
nature.com
Happy Christmas & Holidays to All - 2025 brings much excitement f/ @CamNeuro 1. MPhil closes for funded applications Jan 7th 2. Cam NeuroWorks Fellowship Apps close Jan 17th 3. CNS2025 takes place on April 8th 4. 8th Biennial Symposium returns on Sept 10th-11th (Opens Jan '25!)🎄
A postdoctoral Research Associate position is available in the @LakatosLab in complex human neural organoid-based ALS disease modelling at @Cambridge_Uni : www.jobs.cam.ac.uk/job/49564/ We also advertise a Research Lab Technician post: www.jobs.cam.ac.uk/job/49621/
Stem Cell Models of Neurodegeneration International Symposium - scmnd.com/Speakers.html - a meeting to join!
3D human brain organoid neuronal network analysis strategies: an exciting collaborative work led by Susanna Mierau - and more to come: www.cell.com/cell-reports...
EMBO Astrocyte Workshop - this will be a 'stellar' meeting. Join us!
