Great discussion of dietary protein and aging in @sciencenews.bsky.social today "The protein craze may not be for everyone", spurred in part by @baileyknopf.bsky.social 's new review article entitled "The hallmarks of protein and amino acid restriction in aging and longevity"

I am delighted to be able to share the latest study from the @LammingLab, “Lifelong restriction of dietary valine has sex-specific benefits for health and lifespan in mice” led by former graduate student Dr. Mariah Calubag www.nature.com/articles/s43...

Lifelong restriction of dietary valine has sex-specific benefits for health and lifespan in mice - Nature Aging

Calubag et al. report that reduced dietary intake of the branched-chain amino acid valine is sufficient to improve healthspan in both male and female mice, as well as to extend lifespan in male mice.

nature.com

I am delighted to be able to share the latest study from the @LammingLab, “Lifelong restriction of dietary valine has sex-specific benefits for health and lifespan in mice” led by former graduate student Dr. Mariah Calubag www.nature.com/articles/s43...

Lifelong restriction of dietary valine has sex-specific benefits for health and lifespan in mice - Nature Aging

Calubag et al. report that reduced dietary intake of the branched-chain amino acid valine is sufficient to improve healthspan in both male and female mice, as well as to extend lifespan in male mice.

nature.com

Online now!✨Calubag et al report that reducing dietary valine extends healthspan in male and female mice, and lifespan in male mice @lamminglab.bsky.social www.nature.com/articles/s43...

Lifelong restriction of dietary valine has sex-specific benefits for health and lifespan in mice - Nature Aging

Calubag et al. report that reduced dietary intake of the branched-chain amino acid valine is sufficient to improve healthspan in both male and female mice, as well as to extend lifespan in male mice.

nature.com

Please enjoy my new review article "Bench to bedside: is rapamycin headed for the docTOR?" Open access at: link.springer.com/article/10.1...

Terrific Department of Medicine Research, and congratulations to Dr. Yang Yeh and Bailey Knopf for winning poster awards and Dr. Mariah Calubag for receiving the DOM Outstanding Graduate Student Award!

Three amazing award winners from the Lamming Lab at the 7th Annual Midwest Aging Consortium Meeting! Congratulations to all the winners and all participants! @baileyknopf.bsky.social Yang Yeh and Amirah Nieves Medina!

Please enjoy the latest publication from our lab "Restriction of Individual Branched-Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice" advanced.onlinelibrary.wiley.com/doi/10.1002/...

Restriction of Individual Branched‐Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice

Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched-chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with...

advanced.onlinelibrary.wiley.com

Had a fantastic metabolism and aging retreat yesterday with the @judisimcox.bsky.social and @wiscosurgicalmetab.bsky.social labs!

With the end of the year upon us, it's time for the 2025 @lamminglab.bsky.social year in review! Some of our accomplishments and successes are described in the thread below.

Pleased to annouce the publication of our new collaboration with Spencer Haws and @johndenu.bsky.social "Depletion of individual dietary amino acids induce distinct metabolic and chromatin states"

Pleased to announce the publication of talented postdoc Dr. Yeh's new paper "Ketogenesis is Dispensable for the Metabolic Adaptations to Caloric Restriction"!

We are excited to share our first WiSLiM manuscript! With the help of @lamminglab.bsky.social and Dr. Cholsoon Jang, we attempt to challenge the dogmatic approach to post-bariatric surgery diet with some surprising results... @wiscsurgery.bsky.social @uwhealth.bsky.social

Cell Reports Medicine@cp-cellrepmed.bsky.social · 8mo ago

Online now: A low-protein diet drives short- and long-term improvements in metabolic health in a mouse model of sleeve gastrectomy

Perhaps the most important paper of the decade with respect to how cells sense amino acid insufficiency, finally laying to rest the idea that GCN2 is activated by uncharged tRNAs!

Susan Shao@sshaolab.bsky.social · 10mo ago

Beautiful reconstitution of amino acid stress-dependent ISR activation by my @harvardcellbio.bsky.social colleagues presenting a unifying mechanism for GCN2 activation, which requires ribosome collisions and is enhanced by cognate uncharged tRNA in the A site! www.science.org/doi/10.1126/...

We have a thesis defense to celebrate today, but first - we need to celebrate the publication of former student Dr. Michaela Trautman's opus, "Dietary isoleucine content modulates the metabolic and molecular response to a Western diet in mice" now in Mol Metab! www.sciencedirect.com/science/arti...

Our most recent work by graduate student @mariahcalubag - demonstrating the sex-specific extension of lifespan by valine restriction was presented last week at #ARDD2025 and is now available on bioRxiv! Thanks to Daniela Bakula, @scheibyeknudsenlab.bsky.social, and Alex Zhavoronkov for the invite!

"Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer's disease" from first author Dr. Reji Babygirija and with our collabs including @wiscosurgicalmetab.bsky.social is now available online! www.nature.com/articles/s41...

Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer’s disease - Nature Communications

Caloric restriction improves Alzheimer’s Disease outcomes in mice, but this diet not only reduces calories, but imposes a prolonged fast between meals. Here, the authors show this fast is essential to...

nature.com

I am pleased to report our new manuscript from graduate student Mariah Calubag and collaborators and colleagues, "Tissue-Specific Effects of Dietary Protein on Cellular Senescence Are Mediated by Branched-Chain Amino Acids" is now available! onlinelibrary.wiley.com/doi/10.1111/...

Pleased to announce the last major project from former graduate student Dr. Babygirija is now available on biorxiv - "Restriction of individual branched-chain amino acids has distinct effects on the development and progression of Alzheimer's disease in 3xTg mice" www.biorxiv.org/content/10.1...

Restriction of individual branched-chain amino acids has distinct effects on the development and progression of Alzheimers disease in 3xTg mice

Dietary protein is a critical regulator of metabolic health and aging in diverse species. Recent discoveries have determined that many benefits of a low protein diet are the result of reduced consumpt...

biorxiv.org

Another win for rapamycin: www.nature.com/articles/s41...

Effect of preoperative rapamycin supplementation on perioperative clinical frailty and cognitive performance in a murine model undergoing anesthesia and surgery - Scientific Reports

Scientific Reports - Effect of preoperative rapamycin supplementation on perioperative clinical frailty and cognitive performance in a murine model undergoing anesthesia and surgery

nature.com

Sad to learn we lost Keith Blackwell, an unsung hero of the aging field. Keith showed rapamycin extends C. elegans lifespan, that mTORC2 has diet-dependent effects on aging, and linked together skn1 TOR splicing and aging. www.legacy.com/us/obituarie...

THOMAS BLACKWELL Obituary (1957 - 2025-05-09) - Boston, MA - Boston Globe

View THOMAS KEITH BLACKWELL's obituary, send flowers and sign the guestbook.

legacy.com

Excited to collaborate with Caroline Alexander’s group and @lamminglab.bsky.social demonstrating the contribution of dietary lipids to skin lipids and their insulating properties. Proud of Raghav for leading this collaboration in my lab! @natcomms.nature.com www.nature.com/articles/s41...

Dietary lipids are largely deposited in skin and rapidly affect insulating properties - Nature Communications

The mechanisms underlying the regulation of the skin thermal barrier are poorly understood. Here the authors show that the thermal properties of the skin are reactive to diet and that skin is a target...

nature.com

Thrilled to have our story on the regulation of lysosomal lipids out in @cp-cellmetabolism.bsky.social! The work was led by two outstanding grad students Jess Davidson and Raghav Jain probing mechanistic control of energy expenditure @hhmi.org @uwbiochem.bsky.social

Cell Metabolism@cp-cellmetabolism.bsky.social · last yr.

Online now: Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV

Online now: Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV

Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV

Davidson et al. demonstrated that liver lysosomes orchestrate the metabolic adaptation to cold by rewiring lipid processing. They show that phospholipase A2 group XV (PLA2G15) breaks down bis(monoacylglycerol)phosphate (BMP) lipids to shift lysosomal function and metabolism in response to direct transcription factor EB regulation.

dlvr.it

Glad to report that this tour de force from our collaborator Caroline Alexander (with a bit of assistance from our lab in the form of Michaela Trautman) is now out: "Dietary lipids are largely deposited in skin and rapidly affect insulating properties" www.nature.com/articles/s41...

New in GeroScience, "A machine learning approach for quantifying age-related histological changes in the mouse kidney" with Susan Sheehan, Seamus Mawe, Mandy Chen, Ron Korstanje & J Matthew Mahoney 🧪🤝🖥️ 🧬 #machinelearning #ArtificialIntelligence: link.springer.com/article/10.1...

A machine learning approach for quantifying age-related histological changes in the mouse kidney - G...

The ability to quantify aging-related changes in histological samples is important, as it allows for evaluation of interventions intended to effect health span. We used a machine learning architecture...

link.springer.com

Heading to the @americanaging.bsky.social meeting with @mattyousefzadeh.bsky.social and Holly Brown-Borg!

It was an honor yesterday to hood graduate student Reji Babygirija and escort her at commencement. Big thanks to the keynote speaker for our hooding ceremony Dr. Christine Whelan who gave a highly inspiring and impactful address!

Catching up on the week - awesome @AgingMidwest meeting in Rochester, MN! Congrats to @baileyknopf for a terrific talk and winning a travel award, and @iCCup_Spec for winning a poster award!

I could not be more excited to have our lab's first story online where we report our discovery that HDACs ~reverse~ their activity to ADD acyl groups to lysine! We found this for our favorite ketone body, BHB, but this pathway controls other lysine modifications too!🧵 www.nature.com/articles/s41...

Reversible histone deacetylase activity catalyzes lysine acylation - Nature Chemical Biology

Tsusaka et al. discover that histone deacetylases, which are well known to remove protein modifications, such as lysine acetylation and β-hydroxybutyrylation, can also reverse their chemical activity ...

nature.com