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Laura Hollis

@laurahollis.bsky.social

PhD Microbiology & Infection graduate, UoB | 🏳️‍🌈

5 Posts229 Follower108 Folgt
Ilyas Alav@ilyasalav.bsky.social · 5mo ago

My main postdoc paper is now out in @natureportfolio.nature.com npj Antimicrobials and Resistance! www.nature.com/articles/s44.... Using flow cytometry, we show that the nucleoside analogues azidothymidine, didanosine, stavudine, and trifluridine reduced transfer of AMR plasmids pCT and pKpQIL (1/3)

Mechanistic insights into plasmid transfer inhibition in Enterobacterales by nucleoside analogues - npj Antimicrobials and Resistance

npj Antimicrobials and Resistance - Mechanistic insights into plasmid transfer inhibition in Enterobacterales by nucleoside analogues

nature.com

Lilly Cummins@lillycummins.bsky.social · 7mo ago

I’ve spent a lot of time over the past two years thinking about genome evolution and how recent research revealing complex gene-gene interactions has complicated traditional ‘gene-centric’ genomic approaches to evolution. So here is a review that consolidates these thoughts! rdcu.be/e6pHY

Epistasis and co-adaptation in bacterial genome evolution

Nature Reviews Genetics - Bacterial genome evolution is shaped by epistasis, which can constrain or promote specific evolutionary paths. The authors review how integrating the effects of epistatic...

rdcu.be

Ilyas Alav@ilyasalav.bsky.social · 10mo ago

journals.asm.org/doi/10.1128/... My first corresponding author paper is now out in MMBR @asm.org! In this review, @csdetweiler.bsky.social and I assess the evidence for RND efflux pumps as virulence determinants in Gram-negative bacteria.

Beyond antibiotic resistance: evidence for resistance-nodulation-division (RND) efflux pumps as virulence determinants | Microbiology and Molecular Biology Reviews

SUMMARYEarly in evolution, cells acquired the ability to use energy to export waste and toxic products against a concentration gradient. In Gram-negative bacteria, the resistance-nodulation-cell divis...

journals.asm.org

Lilly Cummins@lillycummins.bsky.social · last yr.

🚨New pre-print 🚨 We introduce our new tool GOLD-GWAS and demonstrate its use by digging into the evolution of MRSA facilitated by SCCmec This work was led by talented PhD student @seungwonko.bsky.social who did most of the computational heavylifting 1/n www.biorxiv.org/content/10.1...

Genome co-adaptation and the evolution of methicillin resistant Staphylococcus aureus (MRSA)

Background: Antimicrobial resistance (AMR) in bacterial pathogens is a major threat to global health, rendering standard treatments ineffective and increasing the risk of severe infection or death. Re...

biorxiv.org

Lilly Cummins@lillycummins.bsky.social · 3y ago

Very happy to have completed my viva this morning 🥳 Thanks to my examiners and my supervisors @alanmcn1.bsky.social @nwheeler443.bsky.social for all their support throughout my PhD

Alan McNally@alanmcn1.bsky.social · 3y ago

Its now official that the amazing @lillycummins.bsky.social is a super phenomenal microbial genomicst. PhD viva passed with NO CORRECTIONS! Even with Jukka Corander as examiner! Thanks to Jukka, @bacterioskeptic.bsky.social and @jessicamablair.bsky.social for examining

Rebecca J Hall@drrebeccajhall.bsky.social · 3y ago

Well done for getting this out @lillycummins.bsky.social! @alanmcn1.bsky.social www.microbiologyresearch.org/content/jour...

Parallel loss of type VI secretion systems in two multi-drug-resistant Escherichia coli lineages

The repeated emergence of multi-drug-resistant (MDR) Escherichia coli clones is a threat to public health globally. In recent work, drug-resistant E. coli were shown to be capable of displacing comm...

microbiologyresearch.org