www.bbc.co.uk/news/article... Ranked worst, but 77% of surveyed people were satisfied? I’m sorry, but who did they survey exactly? Surely, not anyone who commutes with @crosscountryuk.bsky.social. I can tell you first hand that they are epitome of human misery. 🤡

Birmingham-based CrossCountry ranked Britain's worst train operator

Transport Focus asks it to reduce delays and provide better information during disruption.

bbc.co.uk

Recruiting a postdoc to join my lab at @lshtm.bsky.social to work in an MRC porgramme grant funded project to dissect the gut colonziation by Klebsiella. In vivo and in vitro models, and new approaches to identify Klebsiella factors involved. jobs.lshtm.ac.uk/vacancy.aspx...

Job Opportunity at LSHTM: Research Fellow

The London School of Hygiene & Tropical Medicine (LSHTM) is one of the world’s leading public health universities. Our mission is to improve health and health equity in the UK and worldwide; working i...

jobs.lshtm.ac.uk

Having read through nearly 200 applications for my Wellcome Trust-funded PDRA post, one simple advice I can give to applicants is make your CV more concise and digestible.

Woman Rubs Eyes: Can't Unsee

ALT: Woman Rubs Eyes: Can't Unsee

static.klipy.com

One week left to apply for two 3-year postdocs in the lab on molecular mechanisms of Burkholderia pathogenesis. Posts associated with Magdalen College. Our lab is based in the Dunn School of Pathology with amazing collaborators at Oxford and MORU magdalencareers.pinpointhq.com/postings/c90...

Calleva Centre Postdoctoral Researchers- The deadly enigma of melioidosis: Decoding the pathogenesis of Burkholderia pseudomallei.

Job Opening: Calleva Centre Postdoctoral Researchers- The deadly enigma of melioidosis: Decoding the pathogenesis of Burkholderia pseudomallei. at Magdalen College in Central Oxford.

magdalencareers.pinpointhq.com

I don’t think I’ve had a single on time @crosscountryuk.bsky.social train for the past week. How are you still allowed to operate? 😭

Ryan Reynolds' Facepalm: Hopeless Andrew Paxton Moment

ALT: Ryan Reynolds' Facepalm: Hopeless Andrew Paxton Moment

static.klipy.com

Brilliant new review in Plos Pathogens looking at how RND efflux pumps contribute to virulence from @ilyasalav.bsky.social and Corella Detweiler. This one is going to be super useful for efflux folks! 🤩https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1014228

How resistance-nodulation-division (RND) efflux pumps contribute to virulence

In Gram-negative bacteria, multi-subunit efflux pumps transport molecules across the inner membrane, periplasm, and outer membrane to the extracellular environment. These efflux pumps include the Resi...

journals.plos.org

Our recent review on the role of RND efflux pumps in bacterial virulence made it to the front page of @plos.org Pathogens! 😄

Excited to share @csdetweiler.bsky.social and my review article in @plos.org Pathogens exploring how resistance-nodulation-division (RND) efflux pumps contribute to bacterial virulence. journals.plos.org/plospathogen...

How resistance-nodulation-division (RND) efflux pumps contribute to virulence

In Gram-negative bacteria, multi-subunit efflux pumps transport molecules across the inner membrane, periplasm, and outer membrane to the extracellular environment. These efflux pumps include the Resi...

journals.plos.org

Excited to share @csdetweiler.bsky.social and my review article in @plos.org Pathogens exploring how resistance-nodulation-division (RND) efflux pumps contribute to bacterial virulence. journals.plos.org/plospathogen...

How resistance-nodulation-division (RND) efflux pumps contribute to virulence

In Gram-negative bacteria, multi-subunit efflux pumps transport molecules across the inner membrane, periplasm, and outer membrane to the extracellular environment. These efflux pumps include the Resi...

journals.plos.org

Our paper is finally out! 🥳 If you want to know how a single Salmonella effector rewires the whole macrophage transcriptional landscape by hijacking one host transcription factor, check our latest research! Thanks to the @thurstonlab.bsky.social and @peterwshill.bsky.social labs for an amazing work!

Salmonella effector SteE reprograms the macrophage regulatory network to drive specific hyperactivation of STAT3 target genes

The ability of Salmonella Typhimurium to exploit macrophages as a niche for survival, replication, and dissemination is central to its pathogenesis. T…

sciencedirect.com

I’m looking to hire a talented postdoctoral research assistant to work with me on my Wellcome Trust-funded project at the @dunnschool.bsky.social If you’re interested in bacterial pathogenesis and host-pathogen interactions, please apply below! my.corehr.com/pls/uoxrecru...

New paper! We have written a (hopefully) simple primer on microbial energy metabolism - how do bacteria harvest energy from their environment, and how does this impact their behaviour? www.microbiologyresearch.org/content/jour...

Microbial Primer: Bacterial energy metabolism

All cells need energy to perform their functions. This primer introduces energy metabolism in bacteria, with a focus on key pathways and examples from model organisms, while acknowledging that bacteri...

microbiologyresearch.org

Applications are officially OPEN for the 2027 Gordon Research Conference on Multidrug Efflux Systems. 📅 When: March 21–26, 2027 📍 Where: Ventura, California 🔗 Apply here: www.grc.org/multi-drug-e... #GRC #MultidrugEfflux

'Decision in process'

homer simpson from the simpsons is adjusting his tie in a doorway .

ALT: homer simpson from the simpsons is adjusting his tie in a doorway .

media.tenor.com

My main postdoc paper is now out in @natureportfolio.nature.com npj Antimicrobials and Resistance! www.nature.com/articles/s44.... Using flow cytometry, we show that the nucleoside analogues azidothymidine, didanosine, stavudine, and trifluridine reduced transfer of AMR plasmids pCT and pKpQIL (1/3)

Meet Rundy! We adopted him back in January and he’s already taken over my life! 😃🥰

And the preprint is out! www.biorxiv.org/content/10.6... We compared plasmid conjugation in liquid and on solid across 13 AMR plasmids with different types of conjugative pili.

Tatiana Dimitriu@tatianadimitriu.bsky.social · 4mo ago

First paper submitted fully from the lab!

I thought finding reviewers was the major bottleneck when submitting a paper, but now it seems journals struggle to find willing and able editors too...

a close up of a stuffed monkey wearing a green shirt and blue overalls .

ALT: a close up of a stuffed monkey wearing a green shirt and blue overalls .

media.tenor.com

Starry night in Leamington Spa ✨

Does anyone have experience with fixing Salmonella cells prior to flow cytometry as my current institution does not run BSL-2 organisms in their flow machines. I need to measure intracellular dye accumulation, but worried about the effects of fixation on membrane permeability/integrity #academicsky

me on editorial manager as soon as I submit a paper

a person is using a bosch drill to drill the f5 and f6 keys

ALT: a person is using a bosch drill to drill the f5 and f6 keys

media.tenor.com

We were deeply saddened to learn of the death of Professor Jeff Cole, a long-standing member who held many positions in the Society. Jeff was elected an Honorary Member in 2011. You can read his full obituary here: microb.io/46xYzkz

I’ve spent a lot of time over the past two years thinking about genome evolution and how recent research revealing complex gene-gene interactions has complicated traditional ‘gene-centric’ genomic approaches to evolution. So here is a review that consolidates these thoughts! rdcu.be/e6pHY

Epistasis and co-adaptation in bacterial genome evolution

Nature Reviews Genetics - Bacterial genome evolution is shaped by epistasis, which can constrain or promote specific evolutionary paths. The authors review how integrating the effects of epistatic...

rdcu.be

I am deeply saddened by Jeff's passing. Jeff lived and breathed microbiology, and was still very much part of the microbiology community in @imibirmingham.bsky.social until a few weeks ago. He was supportive to students and staff and will be sorely missed by many, here in Birmingham and elsewhere

Institute of Microbiology and Infection @imibirmingham.bsky.social · 5mo ago

It is with deep sadness that we share the passing of Professor Jeff Cole. An esteemed academic, Jeffs research on bacterial adaptation to oxygen and nitrosative stress made a lasting impact on the field. He mentored nearly 60 doctoral students, our thoughts are with his family, friends & colleagues

It’s 2026 and reviewers still want RT-PCR to ‘confirm’ RNAseq data

a woman is standing in front of a blackboard with the words sideways written on it

ALT: a woman is standing in front of a blackboard with the words sideways written on it

media.tenor.com

#NatMicroPicks More than just pumps? 🦠💊 Bacterial efflux pumps not only block drug entry but also disrupt intracellular drug–target interactions by preventing repeated drug rebinding #MicroSky www.science.org/doi/10.1126/...

Efflux pumps control intracellular drug-target kinetics by limiting rebinding in bacteria

Efflux pumps disrupt antibiotic rebinding inside bacterial cells, amplifying multidrug resistance.

science.org

Say hi to Rundy everyone! We rescued him as a stray from Cyprus through a charity. He’s the sweetest boy! 🥰

Loved being @ox.ac.uk last wk for OxBacNet & seeing so many past @imibirmingham.bsky.social friends! Presented @microbesng.bsky.social's poster: “To long read or not to long read” showing how ONT long-read sequencing outperforms Illumina for plasmid de novo assembly & #AMR gene detection #MicroSky

I find that I always have to fight harder for a fair/higher salary, compared to my friends in industry. That shouldn’t be the case. I trained hard for many years and should be paid accordingly.

Nature@nature.com · 7mo ago

Academia too often has a ‘passion first, money second’ culture. Overcoming this mindset is crucial for building a happy career go.nature.com/4bvaCCh

The coolest finding of my PhD is finally out! E. coli has a 7th RND pump that is present in phylogroups B2/D/E/F but absent in A/B1/C. As a result EefABC has been absent in all K-12 RND studies! Co-authored by the very talented Dr. Lizzy Darby. @jessicamablair.bsky.social doi.org/10.1099/mgen...

The Resistance-Nodulation-Division efflux pump EefABC is highly conserved within lineages of E. coli commonly associated with infection

Resistance-nodulation-division (RND) efflux pumps confer multidrug resistance in Gram-negative bacteria and are critical for many physiological functions including virulence and biofilm formation. The...

doi.org