Excited to share our latest publication, out now in @natcomms.nature.com !🧠🔍 Accumulating virtual rewards enhances both decision-making accuracy and neural value encoding in dorsal anterior cingulate cortex by dynamically shifting a goal-dependent internal reference point. doi.org/10.1038/s414...

If there’s one thing biological systems aren't, it's homogeneous. It's common knowledge that heterogeneity is everywhere, from molecular scales to people. But is the fact of just being "different" what actually matters?

Cortical traveling waves in time and space: Physics, physiology, and psychology www.sciencedirect.com/science/arti...

Cortical traveling waves in time and space: Physics, physiology, and psychology

Widefield recordings acquired with different resolutions and in diverse species have revealed that cortical activity often propagates as waves of exci…

sciencedirect.com

Small-scale biological variation across regions plays a major role in organizing global rhythmic cortical dynamics. Spatially structured heterogeneity shapes large-scale cortical dynamics in a model of the human cortex doi.org/10.1073/pnas... #neuroscience

Spatially structured heterogeneity shapes large-scale cortical dynamics in a model of the human cortex | PNAS

The human brain displays substantial spatial variability in molecular, anatomical, and physiological organization. Yet, how this heterogeneity shap...

doi.org

Spatially structured heterogeneity shapes large-scale cortical dynamics in a model of the human cortex www.pnas.org/doi/10.1073/...

Temporal fingerprints of TMS-evoked potentials across thalamocortical circuits www.biorxiv.org/content/10.6...

Temporal fingerprints of TMS-evoked potentials across thalamocortical circuits

Background: Electroencephalographic (EEG) potentials evoked by transcranial magnetic stimulation (TMS) offer a direct window into cortical dynamics. Yet, a systematic exploration of their morphologica...

biorxiv.org

Functional Whole-Brain Models: A New Framework for Unifying Brain Structure and Cognitive Function Can we build functional whole-brain models integrating structural and dynamical realism with task-performing capacity? Check our new work here: arxiv.org/abs/2605.18118 Spearheaded by Mario Senden

Functional Whole-Brain Models: A New Framework for Unifying Brain Structure and Cognitive Function

Contemporary computational neuroscience features two prominent modeling traditions. Bottom-up whole-brain modeling (WBM) builds biophysically detailed simulations of brain structure and dynamics, wher...

arxiv.org

Excited to share a new paper from our lab, just in time for Easter, where we characterize how arousal modulates different excitatory cell-types in the auditory cortex! www.science.org/doi/10.1126/...

Pupil-linked arousal heterogeneously modulates cell-type–specific sensory processing

Two-photon imaging and pupillometry reveal how arousal modulates excitatory neuron subtypes in auditory cortex.

science.org

For more than a century, the study of brain lesions has been central to understanding cognitive processes and normal brain function (e.g., Broca’s studies). However, what electrophysiological signatures emerge following a brain lesion?

Development of structure–function coupling in human brain networks during youth www.pnas.org/doi/10.1073/... Structure–function coupling in macroscale human brain networks www.nature.com/articles/s41...

Development of structure–function coupling in human brain networks during youth | PNAS

The protracted development of structural and functional brain connectivity within distributed association networks coincides with improvements in h...

pnas.org

@overleaf.com Subscription overpriced; free version extremely downgraded from what it used to be.

Neuroscience history: Were McCormick et al. (1985) the first to coin the terms "regular" and "fast" spiking? Comparative Electrophysiology of Pyramidal andSparsely Spiny Stellate Neurons of the Neocortex. J Neurophysiol.

Just published my review of neuroscience in 2025, on The Spike. The 10th of these, would you believe? This year we have foundation models, breakthroughs in using light to understand the brain, a gene therapy, and more Enjoy! medium.com/the-spike/20...

2025: A Review of the Year in Neuroscience

Enlightening the brain

medium.com

This is your brain on Ritalin. Got your attention? Stimulant medications like Ritalin (methylphenidate) do, but not in the way you might think. They don't act directly on the brain’s attention systems! Find out what's really happening in @cellpress.bsky.social. doi.org/10.1016/j.ce...

Finally got the job ad—looking for 2 PhD students to start spring next year: www.gao-unit.com/join-us/ If comp neuro, ML, and AI4Neuro is your thing, or you just nerd out over brain recordings, apply! I'm at neurips. DM me here / on the conference app or email if you want to meet 🏖️🌮

Do we need to study animals in the wild to fully understand the brain? Maybe. OTOH, I sit in front a computer all day. bigthink.com/neuropsych/n... #neuroscience

The next revolution in neuroscience is happening outside the lab

By tracking brain activity as primates move freely in the wild, neuroethology could reshape what we think we know about our own minds.

bigthink.com

New preprint out! How does criticality propagate from local neuronal circuits to whole-brain dynamics? We tackle this with a multiscale, connectome-based mouse model @ldallap.bsky.social . 🧵/n 👉 biorxiv.org/content/10.6...

I am more than pleased to share our new work with you: "Intra- and Interhemispheric Signatures of Criticality at the Onset of Synchronization" biorxiv.org/content/10.6... Short 🧵 1/9:

Intra-and Interhemispheric Signatures of Criticality at the Onset of Synchronization

The cerebral cortex must flexibly alternate between locally segregated activity that supports specialization and long-range interactions that enable integration. How cortical networks balance these co...

biorxiv.org

Cell assemblies are drawing increasing attention in neuroscience, but one could argue that they are just an epiphenomenon. Is the activity of cell assemblies relevant for the brain? The short answer is yes. The long answer is in our paper, now online at PLOS Biology. 🧵👇 1/10 doi.org/10.1371/jour...

Adaptive communication between cell assemblies and “reader” neurons shapes flexible brain dynamics

Cell assemblies have been proposed as key units of brain activity, underlying diverse functions, but their basic features are not well understood. This study shows that interactions between cell assem...

doi.org

State-dependent brain responsiveness, from local circuits to the whole brain elifesciences.org/reviewed-pre...

The brain computes by processing information over time through interactions between connectivity and dynamics that are hard to model. Here we infer these interactions from data and find they better predict cognitive performance! www.nature.com/articles/s41... w/ @lindenmp.bsky.social

Cholinergic heterogeneity facilitates synchronization and information flow in a whole-brain model https://www.biorxiv.org/content/10.1101/2025.10.28.685048v1

I'm really happy to share our latest work: “Cholinergic heterogeneity facilitates synchronization and information flow in a whole-brain model” www.biorxiv.org/content/10.1...

Cholinergic heterogeneity facilitates synchronization and information flow in a whole-brain model

The human brain displays substantial regional variability in molecular, anatomical, and physiological organization. Yet, how this heterogeneity shapes large-scale neuronal dynamics remains poorly unde...

biorxiv.org

Disconnecting part of the brain sends it into a deep sleep www.nature.com/articles/d41...

Disconnecting part of the brain sends it into a deep sleep

Study on the effects of surgical epilepsy treatment adds to researchers’ understanding of unconsciousness.

nature.com

#Hemispherotomy is a surgical treatment for #epilepsy by disconnecting a portion of the #cortex. Michele Colombo, Jacopo Favaro, @anilseth.bsky.social, Marcello Massimini &co show that the isolated cortex has #EEG patterns resembling deep #sleep or #anesthesia @plosbiology.org 🧪 plos.io/3J9ci8X

Have you ever wondered what is the brain activity left in a cortical hemisphere after structural isolation? Check it out: journals.plos.org/plosbiology/...

Hemispherotomy leads to persistent sleep-like slow waves in the isolated cortex of awake humans

Hemispherotomy is a neurosurgical procedure for treating refractory epilepsy by disconnecting a significant portion of the cortex. This study shows that the isolated cortex exhibits EEG patterns resem...

journals.plos.org

Now out in Advanced Intelligent Systems: Exploiting underlying data geometry, we classify brain states efficiently using Riemannian manifolds. A lightweight and interpretable alternative to DNNs. Spearheaded by @arnauya.bsky.social! Check it out: advanced.onlinelibrary.wiley.com/doi/10.1002/...

Riemannian Geometry for the Classification of Brain States with Intracortical Brain Recordings

Geometric machine learning is applied to decode brain states from invasive intracortical neural recordings, extending Riemannian methods to the invasive regime where data is scarcer and less stationa...

advanced.onlinelibrary.wiley.com

www.biorxiv.org/content/10.1... Brainwide hemodynamics predict EEG neural rhythms across sleep and wakefulness in humans | bioRxiv

Brainwide hemodynamics predict EEG neural rhythms across sleep and wakefulness in humans

The brain exhibits rich oscillatory dynamics that play critical roles in vigilance and cognition, such as the neural rhythms that define sleep. These rhythms continuously fluctuate, signaling major ch...

biorxiv.org

Attractors are usually not mechanisms - new blog post: open.substack.com/pub/kording/...

Attractors are usually not mechanisms

The mathematical objects can not be. And the "attractor models" have not been established as mechanisms in mammals

open.substack.com

Are you at the @cnsorg.bsky.social conference? Do you like networks? Brain-like networks? Pretty and structure rich networks? 🙇‍♂️🧠🕸 Come to my Poster 204 this afternoon (or anytime today)!! The poster is right next to the coffee! ☕️ 😉 #CNS2025 #CNS2025Florence 🇮🇹🍝