Introducing peptidiens! Congratulations to the TransCODE consortium on this exciting tour-de-force in @nature.com: nature.com/articles/s41... We look forward to seeing what’s next as lead authors Sebastiaan van Heesch and John Prensner take on our dark proteome challenge as part of team ILLUMINE!

Expanding the human proteome with microproteins and peptideins - Nature

A large-scale proteomics analysis of the dark proteome by the TransCODE Consortium reveals many translated non-canonical open reading frames to encode microproteins and peptideins.

nature.com

Less than 1 week to go until our Cancer Grand Challenges panel at #AACR. Hear insights from our exceptional panellists, and join us afterwards for a networking reception. Mark your calendar and add it to your AACR itinerary: www.abstractsonline.com/pp8/#!/21436... @theaacr.bsky.social

Incredible science was shared at the #TeamPROSPECT scientific retreat this week bringing together experts in epidemiology, oncology, immunology, computational biology & more. A global effort to understand and reverse the rapid rise of early-onset colorectal cancer. #CancerResearch #ColorectalCancer

New research from team PROMINENT (@nlbigas.bsky.social), published in @nature.com, uncovers clues why men face a higher risk of bladder cancer and reveals that tobacco smoke acts as a promoter, not an initiator, in bladder cancer development. Read more: www.cancergrandchallenges.org/news/early-c...

Paul Mischel is championing the importance of odd rings of DNA in tumors—and their promise as targets for cancer therapy. https://scim.ag/4m5x2f3

Weird rings of DNA fuel cancers. This scientist leads the effort to target them

Paul Mischel and others are testing therapies for rogue genetic loops that drive tumor evolution and growth

scim.ag

We are hiring! 🚨 Great opportunity to be at the forefront of cancer research internationally as a @cancergrand.bsky.social Research Portfolio Manager (going to the London office 2 days/week). Apply by: 1 July 2025 Get in touch📩 More info 👇 cancerresearchuk.wd3.myworkdayjobs.com/en-US/Extern...

Research Portfolio Manager (Cancer Grand Challenges)

4,000 professionals, 0 days wasted, 1 incredible purpose. Together we are beating cancer. Research Portfolio Manager (Cancer Grand Challenges) Salary: £46,000 - £54,000 depending on experience plus be...

cancerresearchuk.wd3.myworkdayjobs.com

#ICYMI from team eDyNAmiC: SPACE-seq! Howard Chang's group at @stanfordmedicine.bsky.social published a new method in @pnas.org allowing spatial multi-omics and lineage tracing, coupled with detection of ecDNA copy number. The team went on to show the utility of SPACE-seq in glioblastoma.

Julia Belk@juliabelk.bsky.social · last yr.

Happy to share our paper describing SPACE-seq - a new approach to spatial multiomics and lineage tracing - out today in @pnas.org! 🧵(1/5)

Last week, Regina Barzilay's group @mit.edu released Boltz-2. With accuracy rivalling AlphaFold3, the updated model can now predict small molecule-protein binding affinity. Crucially, Boltz-2 is open source. Read more: bit.ly/4kY1gki (wonderful article by @rebeccaeccles.bsky.social).

Boltz-2: democratising the future of drug design

Open source structure prediction with binding affinity

bit.ly

💡 ecDNA Conference 🗓️ 11–13 June 2025 📍 London, UK 🚨 Register by Monday 5th May (3 days left!!) The full programme for our conference on ecDNA is now confirmed! You can view all the details and register here: www.cancergrandchallenges.org/ecDNA-2025

🚨 New transatlantic research funding! 🚨 We've partnered with the American Cancer Society to co-fund our Biology to Prevention Award, doubling the funding pot for collaborative UK and US prevention research teams. Join us for a webinar on 21 May to find out how to apply: bit.ly/445v4pO

Webinar: Biology to Prevention Award co-funded with American Cancer Society

Join our webinar on 21 May to learn about this new partnership and how to apply for co-funding through the Biology to Prevention Award

bit.ly

What a masterful #AACR25 Plenary talk by Paul Mischel @stanfordmedicine.bsky.social, #CancerGrandChallenges team eDyNAmiC lead) on the role of extrachromosomal DNAs (#ecDNAs) in cancer. As a funder, it’s incredible to see what we've enabled — in front of 21,000 cancer research leaders!

🌟 Hello from #AACR25 🌟 At @cancergrand.bsky.social, we're uniting the world's brightest minds to tackle cancer's toughest challenges. Applications are now open to take on our newest set of challenges, with awards of up to £20m available. Come by booth 2327 to learn more 💭 We're about to open!

Would it even be #AACR25 without the mandatory photo at their "selfie 🤳 station"???

Fantastic science at #AACR25 yesterday! So inspiring to see @cancergrand.bsky.social Challenges like extrachromosomal DNAs #ecDNAs 🧬⭕ (team eDyNAmiC!) and transposable elements 🦘🧬 (key for the Dark Proteome!) highlighted in the 🎓educational sessions. Really cool science being discussed 🔬!

#AACR25 has officially started! I presented at the Professional Development Session "Grant Writing Workshop", sharing UK🇬🇧 & European🇪🇺 funding opportunities in #CancerResearch, and spotlighting our 7 #CancerGrandChallenges. @theaacr.bsky.social @cancerresearchuk.org

The 24/25 edition of @cancergrand.bsky.social progress magazine is now live! Including: 👉key advances from our funded teams 👉 the biggest themes in cancer research from early-onset cancers to AI and cancer as a systemic disease 👉our 7 new challenges features.cancerresearchuk.org/cancergrandc...

DFS 0161 CGC Discover mag 2024

A year of scientific creativity

features.cancerresearchuk.org

@cancergrand.bsky.social funded research featured in The Guardian "Childhood toxin exposure ‘may be factor in bowel cancer rise in under-50s’ "

The Guardian@theguardian.com · last yr.

Childhood toxin exposure ‘may be factor in bowel cancer rise in under-50s’

🚨New in @nature.com @cancergrand.bsky.social Mutographs team identified mutational signatures caused by the bacterial genotoxin colibactin are enriched in early onset colorectal cancer cases. Read more about the findings, the open questions and the curiosities of colibactin 👇 t.co/FfElyKim68

DFS 0161 CGC Discover mag 2024 — Early-onset cancers

A year of scientific creativity

features.cancerresearchuk.org

We are finalizing the programme of our #CancerGrandChallenges Conference on #ecDNAs, and I couldn't be more proud and excited! Watch this space for updates! Also, register soon as we're nearly sold out! 👇 www.cancergrandchallenges.org/ecDNA-2025

Cancer Grand Challenges Conference: extrachromosomal DNA

Taking place on 11 - 13 June 2025 in London, UK. Registration is now open.

cancergrandchallenges.org

A big congratulations to #CancerGrandChallenges Scientific Committee member, Karen Vousden for her AACR-G.H.A. Clowes Award for Outstanding Basic Cancer Research and to OPTIMISTICC co-team lead Matthew Meyerson on his AACR Award for Outstanding Achievement in Pathology in Cancer Research! 🙌👏🧬 #AACR

American Association for Cancer Research (AACR)@theaacr.bsky.social · 2y ago

Congratulations to the recipients of the 2025 AACR Scientific Achievement Awards and Lectureships. This year’s distinguished class of awardees will be recognized at #AACR25 in Chicago. www.aacr.org/about-the-aa...

The #CancerGrandChallenges Mutographs team reveals how tobacco smoke damages DNA to drive different types of head and neck cancer 🧬 They also show that smoking combined with drinking alcohol can more than double the damaging effect on DNA ⤵️ www.sanger.ac.uk/news_item/sc...

Scientists unlock secret behind how smoking and drinking alcohol causes cancer

Scientists have revealed exactly how tobacco smoke damages DNA to drive the development of different types of head and neck cancer, a finding that could unlock new treatments and prevention strategies...

sanger.ac.uk

New @theaacr.bsky.social Cancer Discovery paper on ecDNA in urothelial carcinoma reveals how ecDNAs: 💡 Drive #BladderCancer evolution 💡 Promote immune evasion 💡 Amplify oncogenes 💡 Fuel tumour heterogeneity 💡 May be a biomarker in urine for non-invasive detection aacrjournals.org/cancerdiscov...

Fantastic achievement and recognition to some of our @cancergrand.bsky.social researchers! Congrats to Josep Tabernero @joseptabernero.bsky.social (vhio.bsky.social) and Paul Mischel (@stanford.edu) on being elected as Fellows of the AACR Academy Class of 2025!

American Association for Cancer Research (AACR)@theaacr.bsky.social · 2y ago

The AACR is proud to announce our newly elected class of Fellows of the AACR Academy. The AACR Academy honors distinguished scientists whose contributions have propelled significant innovation and progress against cancer. Learn more: buff.ly/8a8WUn9 #AACRFellows

Tackling Cancer through Global Team Science aacrjournals.org/cancerdiscov...

Nuria Lopez-Bigas@nlbigas.bsky.social · 2y ago

Seven New Cancer Grand Challenges Announced www.cancergrandchallenges.org/new-challenges With awards of up to £20m ($25m). Expressions of Interest are now open. @cancergrand.bsky.social #CancerGrandChallenges

Interesting cancer grand challenges just announced. Funders looking for interdisciplinary & international teams. I'm an outsider, but fascinated that some of them have clear eco-evo cell-population dynamical component. finance.yahoo.com/news/cancer-... @cancergrand.bsky.social @cancerresearchuk.org

Cancer Grand Challenges Announces Seven New Challenges Representing Some of the Toughest Questions Facing Cancer Research Today

BOSTON, March 05, 2025--Cancer Grand Challenges announces seven new challenges representing some of the toughest questions facing cancer research today.

finance.yahoo.com

7 new Cancer Grand Challenges announced: www.cancergrandchallenges.org/new-challenges @cancergrand.bsky.social

New challenges

Explore the challenges currently open for Expressions of Interest.

cancergrandchallenges.org

In collaboration of CRUK, the NCI and many other funders new sets of cancer grand challenges are announced today

Seven New Cancer Grand Challenges Announced www.cancergrandchallenges.org/new-challenges With awards of up to £20m ($25m). Expressions of Interest are now open. @cancergrand.bsky.social #CancerGrandChallenges

New Challenges just announced!! £20m per international team! -The dark proteome -Mechanisms driving mutational signatures -AI-human collaborations in cancer -Cancer avoidance -The nervous system and cancer -Rewiring cancer cells -TME dynamics More info: www.cancergrandchallenges.org/new-challeng...

⏳ 14 MARCH ABSTRACT DEADLINE ⏳ 🚨 2 weeks! If you'd like the opportunity to present your work alongside this 👇 stellar line-up of researchers at our ecDNA conference, ensure you submit your abstract by 14 March. Learn more: bit.ly/ecDNAConfere...