🧬NEW PAPER🧬 To what extent is cancer development deterministic? Does the germline genome affect that predictability? Find out in our #StrainDifferences paper @nature.com "Genetic background sets the trajectory of experimental cancer evolution" www.nature.com/articles/s41... 🧵[1/14]

Genetic background sets the trajectory of experimental cancer evolution - Nature

Experimentally replaying tumour evolution in divergent mouse strains reveals the importance of interactions between genetic ancestry and acquired cancer-driving mutations in shaping the earliest stage...

nature.com

Tumor promotion through the lens of evolution This review grew out of many long conversations, shared ideas, and lively discussions It has been a real pleasure to think together with Allan, Paul, Eve, and Abel about how tumours develop and how carcinogens shape cancer risk rdcu.be/fdC2J

Tumour promotion through the lens of evolution

Nature - This Review revisits tumour initiation and promotion in light of clonal diversity and the presence of cancer driver mutations in normal tissues, aiming to understand mechanisms that enable...

rdcu.be

Happening tomorrow! Join our upcoming webinar, organised by the @helloeacr.bsky.social, on 09 April (14:00–15:30 CET) to explore the new CGI platform, virtual Molecular Tumour Boards, and a real clinical use case from Lyon. Save your spot: us02web.zoom.us/webinar/regi...

📢 This Week at #IRBBarcelona: Join us for a plenary #seminar this Friday, with Dr. @isidrolauscher.bsky.social from @ebi.embl.org @sangerinstitute.bsky.social @cancerresearchuk.org  🤝 Hosted by @nlbigas.bsky.social and @milanlab.bsky.social  Register here ➡️ https://shorturl.at/imwHx 🧪

Today is the #InternationalDayofWomenandGirlsinScience - celebrating women across our @helloeacr.bsky.social community 🙌 From Board members across Europe to the #EACR HQ team and the scientists we serve worldwide, women play a central role in advancing cancer research every day #WomeninScience 👩🏻‍🔬🧪

#internationaldayofwomenandgirlsinscience #eacr #womeninscience | Johanna Joyce

Today is the #InternationalDayofWomenandGirlsinScience - a moment to recognise and celebrate women across all of the #EACR community 🙌 From Board members working together across Europe, to the dedic...

linkedin.com

This week, Loic Verlingue (CLB) & Santi Demajo (@irbbarcelona.org) represented CGI-Clinics at the EUnetCCC seminar 'Advancing Precision Oncology through Molecular Tumour Boards' - a fantastic opportunity to bring the CGI tool to the forefront of the European precision cancer diagnostics community 🌍

Huge congratulations to Fran on being awarded the ERC Consolidator Grant! 🎉 Such a well-deserved recognition of an outstanding trajectory and a truly creative, exciting proposal on T-cell clonal hematopoiesis. Can’t wait to see the discoveries that come out of this project. So proud of you! 👏✨

Vall d’Hebron Institute of Oncology@vhio.bsky.social · 8mo ago

👏 Congratulations to Francisco Martínez Jiménez‼️ The head of the Computational Immunogenomics Group at #VHIO has been awarded an @erc.europa.eu Consolidator Grant to uncover new immunotherapy strategies built on expanded T-cell clones. ➡️ https://linke.to/ERCFranMVHIO #ERCCoG @cerca.cat

Today, Nuria López-Bigas @nlbigas.bsky.social and Mònica Sánchez-Guixé @guixe-m.bsky.social are at the #BarcelonaBiomed Conference, organised by #IRBBarcelona. A great occasion to share our projects related to childhood cancers.

Delighted and honored to have hosted the 3rd PROMINENT Retreat in Barcelona. The @cancergrand.bsky.social project led by Allan Balmain, Paul Brennan and Nuria Lopez-Bigas, is progressing thanks to the excellent science being performed by all the teams. Great meeting and best participants!

Don't miss our extraordinary #seminar to be held next week, with @jdegregori.bsky.social, from the University of Colorado Anschutz (@cuanschutz.bsky.social). Host: Dr. @nlbigas.bsky.social (@bbglab.bsky.social, #IRBBarcelona) Register here 👉 https://shorturl.at/n74Th #CancerResearch 🧪

Excited to see this thought provoking piece of work now published. So much more to learn about mutagenesis in healthy tissue.

Nuria Lopez-Bigas@nlbigas.bsky.social · 10mo ago

🚨 New paper alert! Sex and smoking bias in the selection of somatic mutations in human bladder www.nature.com/articles/s41... by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)

Very excited to share our new paper on the influence of biological sex and smoking in the clonal landscape of normal human bladder, just published in Nature. A big thank you and congrats to all the authors, specially to @raquelbmi.bsky.social for all the shared efforts in this journey! ⬇️More info⬇️

Nuria Lopez-Bigas@nlbigas.bsky.social · 10mo ago

🚨 New paper alert! Sex and smoking bias in the selection of somatic mutations in human bladder www.nature.com/articles/s41... by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)

Very happy to share that our paper on the influence of biological sex and smoking in the clonal landscape of the normal human bladder is out today in Nature. Kudos to all the authors and especially to @ferriol.bsky.social for coming along with me during this project's journey! 🧵Summary following ⬇️

Nuria Lopez-Bigas@nlbigas.bsky.social · 10mo ago

🚨 New paper alert! Sex and smoking bias in the selection of somatic mutations in human bladder www.nature.com/articles/s41... by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)

🚨 New paper alert! Sex and smoking bias in the selection of somatic mutations in human bladder www.nature.com/articles/s41... by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)

Sex and smoking bias in the selection of somatic mutations in human bladder - Nature

Sex bias and association with smoking history identified in the landscape of driver mutations and clonal expansions in normal human bladder tissue may explain the higher bladder cancer risk in men and smokers.

nature.com

New paper from our lab - ‪@bbglab.bsky.social‬. Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection academic.oup.com/nar/article/... Kudos to Stefano, Olivia, @fmuinos.bsky.social and Abel

Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection

Abstract. Identifying the genes capable of driving tumorigenesis in different tissues is one of the central goals of cancer genomics. Computational methods

academic.oup.com

Back after a few days in Lisbon for the annual #EACR2025 conference! Inspiring and great science. Glad for the opportunity to present our work, coming home with a bunch of new ideas! @bbglab.bsky.social @ferriol.bsky.social

@ewaszczurek.bsky.social explains how evolution is the generative process of cancer at #AACR25.

Jeffrey Townsend (that's me!) presents on dismantling the coarse approximation of drivers and passengers in cancer at #AACR25. Thank you @nlbigas.bsky.social for the photo!

@nlbigas.bsky.social explains how they assemble a compenduim of driver genes 🧬 in cancer at #AACR25.

We're at #CCG2025 in Amsterdam! Project Coordinator @nlbigas.bsky.social is delivering a keynote lecture on the CGI-Clinics project today, 'Data-driven cancer genome interpretation for clinical decision making': www.ccg2025.eu/speaker/nuri...

European Association of Cancer Reasearch statement on threats to cancer reasearch @helloeacr.bsky.social eacr.org/statement-on...

#standupforscience Boston

Tackling Cancer through Global Team Science aacrjournals.org/cancerdiscov...

Nuria Lopez-Bigas@nlbigas.bsky.social · last yr.

Seven New Cancer Grand Challenges Announced www.cancergrandchallenges.org/new-challenges With awards of up to £20m ($25m). Expressions of Interest are now open. @cancergrand.bsky.social #CancerGrandChallenges

Seven New Cancer Grand Challenges Announced www.cancergrandchallenges.org/new-challenges With awards of up to £20m ($25m). Expressions of Interest are now open. @cancergrand.bsky.social #CancerGrandChallenges

🌟NEW PREPRINT ALERT!🌟 We are very pleased to introduce #StrainDifferences: “Genetic background sets the trajectory of cancer evolution” www.biorxiv.org/content/10.1... 🧵[1/12]

Genetic background sets the trajectory of cancer evolution

Human cancers are heterogeneous. Their genomes evolve from genetically diverse germlines in complex and dynamic environments, including exposure to potential carcinogens. This heterogeneity of humans,...

biorxiv.org

Less than a week for registration. Check out the program: www.ccg2025.eu. With keynotes by @nlbigas.bsky.social and @charlesswanton.bsky.social and exciting sessions on clinical implementation and impact, research insights and future developments around cancer whole genome sequencing #ccg2025

Molt trista per aquesta notícia. Gran professor, comunicador i científic. Una persona propera que ha deixat empremta a tots els que hem tingut la sort d'interaccionar amb ell. Deixa un llegat immens a l'IRB i a la ciència al nostre país.

IRB Barcelona@irbbarcelona.org · 2y ago

With great sadness, we announce the passing of Dr. Joan Guinovart, founder, former scientist, director, and Emeritus Professor of IRB Barcelona. Our deepest condolences to his loved ones and the IRB Barcelona community. You will always be remembered, Captain.

🎉 I'm thrilled to announce that OpenVariant is finally published! A comprehensive toolkit to facilitate reading, parsing and refinement of diverse input file formats in a customizable structure, all within a single process. @bbglab.bsky.social at @irbbarcelona.bsky.social doi.org/10.1093/bioi...

OpenVariant: a toolkit to parse and operate multiple input file formats

AbstractSummary. Advances in high-throughput DNA sequencing technologies and decreasing costs have fueled the identification of small genetic variants (suc

academic.oup.com

**Clinical Cancer Genomics Conference** First of an annual recurring series. It will be a very important meeting for the advance of clinical implementation of cancer genomics. Proud to be part of it. March 20th-21st 2025 in Amsterdam. Registration open: www.ccg2025.eu #CCG2025

**Mutations in Time and Space** Looking forward to it. Abstract submission is now open broadinstitute.swoogo.com/mits2025/

Tim Coorens@timcoorens.bsky.social · 2y ago

Spread the word! Registration for the "Mutations in Time and Space" conference is open. The meeting is all about the origins, patterns, and consequences of mutations across cells, individuals, populations, species. Abstract submission deadline is Jan 17th broadinstitute.swoogo.com/mits2025/597...