👉 RNA quality control enables antibiotic tolerance: www.cell.com/cell-host-mi... @cp-cellhostmicrobe.bsky.social #RNAseY
RNA quality control enables antibiotic tolerance
Nishimoto et al. experimentally evolve bacteria during infection, revealing a ribosomal “crash and reboot” strategy as a mechanism of antibiotic tolerance. Mutations in the RNA degradosome allow RNA t...
cell.com
🧪 #MicroSky #RNASky Great collaboration with @dunhamlab.bsky.social lab on solving the unusual hexameric structure of a bifunctional nuclease YhaM in complex with 2 distinct RNA substrates. Check out Dunham's summary at www.linkedin.com/posts/christ...
YhaM Structure Revealed in PNAS | Christine Dunham posted on the topic | LinkedIn
We are excited to present our recent research published in PNAS in collaboration with the Yap lab from Northwestern. Congrats to Jacob Mattingly who led our structural biology efforts and Anna Lipońsk...
linkedin.com
cryoEM papers@cryoempapers.bsky.social · 2mo agoStructural insights into RNA recognition by the Staphylococcus aureus exoribonuclease YhaM pubmed.ncbi.nlm.nih.gov/42301784/ #cryoEM
Happy to share our latest paper: www.nature.com/articles/s41... Great collaboration with @ifremer.bsky.social, @cbitoulouse.bsky.social & @pasteur.fr. Studying stress in P. abyssi with near-native, minimally purified ribosomes, we identified HibA, a new hibernation factor widespread in Archaea.
🌼🧬🦠 New #RNA modif newsletter is out: • tRNA mods evolve (bye Fe-S in strepto) • Dus ≠ boring → infection relevant • tRNAs are built, not decorated • rRNA mods = dynamic ribosomes • TadA editing depends on context • host signals → tRNA rewiring → virulence open.substack.com/pub/rnamodif...
📰 🌼 RNA Modifications Newsletter - May 2026
Issue #11
open.substack.com
À Strasbourg, des étudiants étrangers asphyxiés par les frais d’inscription majorés Par @thibaultvetter.bsky.social
À Strasbourg, des étudiants étrangers asphyxiés par les frais d’inscription majorés
L’université de Strasbourg applique déjà en partie la majoration des frais d’inscription pour les étudiants étrangers non européens, que le gouvernement voudrait généraliser. Cinq d’entre eux racontent leurs difficultés à s’acquitter des 3 941 euros demandés et leur crainte de devoir renoncer à leur parcours.
l.mediapart.fr
Postdoctoral Position (Please re-post) A funded postdoctoral position for a recent graduate to study aspects of Neisseria gonorrhoeae pathogenesis, antigenic variation, genetics, or physiology. Please contact Hank Seifert h-seifert@northwestern.edu #Microsky, #Microbiology, #MicrobialEvolution
Seemingly unrelated mutations boost multidrug resistance by promoting ribosome synthesis. Out in #mBio @asm.org, 1st author @lescorneta.bsky.social, great collaboration w/ Dapeng Zhang's and Jade Wang's groups. @nu-bsa.bsky.social #MicroSky #ribosome #AMR journals.asm.org/doi/10.1128/...
Inactivation of a purine biosynthesis repressor promotes ribosome synthesis to overcome antibiotic stress | mBio
The Erm rRNA methyltransferase superfamily represents the most prevalent determinant of MLS resistance in nosocomial Gram-negative and Gram-positive bacteria. Previous studies have established that erm expression is primarily governed by upstream ribosome stalling peptide and the 5′ untranslated regions. Using the widespread S. aureus ermBL-ermB (ermB+) operon as a model system, we unexpectedly identified second-site mutations in purR that synergistically enhance MLS resistance in an ermB+ background. Loss of purR function derepresses nucleotide biosynthesis and ribosome production, thereby promoting bacterial growth under antibiotic stress. While numerous purR single-nucleotide polymorphisms across multiple species have been associated with antibiotic resistance, no study has directly linked these sequence polymorphisms to their regulatory function. Our results highlight the critical role of ribosome abundance and nucleotide metabolism in shaping antibiotic efficacy.
journals.asm.org
Very happy to share our latest work on translation initiation and its regulation in S. aureus. If you are interested in #ribosomes, #bacteria and #translation, this one is for you! Very grateful to all co-authors, especially @bahcer.bsky.social for an amazing job at Cryo-EM data processing!
Extended Shine-Dalgarno motifs govern translation initiation in Staphylococcus aureus - Nature Communications
Kohl et al. combine high-resolution Ribo-seq and cryo electron microscopy to show that the bacterium Staphylococcus aureus uses extended Shine-Dalgarno motifs to initiate translation, which can m...
nature.com
POWERFUL: With snow falling in freezing weather in Chicago last night, the massive anti-ICE/Border Patrol rally wrapped up in front of City Hall as the energized crowd chanted, "I believe that we will win!"
The U.S. Is Funding Fewer Grants in Every Area of Science and Medicine www.nytimes.com/interactive/...
The U.S. Is Funding Fewer Grants in Every Area of Science and Medicine
A quiet policy change means the government is making fewer bets on long-term science.
nytimes.com
"officials said Northwestern researchers have not received payments for National Institutes of Health grants since March, signaling that those funds have been frozen, despite no official word from the Trump administration."
@LaBonneLaB@labonnelab.bsky.social · last yr.I helped explain to the Chicago Tribune the enourmous and irrational damage the NIH funding freeze is causing at Northwestern. “You’re at risk of losing an entire next generation of scientists" "it’s terrifying; it’s completely senseless." www.chicagotribune.com/2025/06/07/w...
@thedailynu.bsky.social Northwestern is still supporting our research despite not receiving any $ from active and new fundable grants. Definitely unsustainable and anxieties are piling up..
Jeremy Berg@jeremymberg.bsky.social · last yr.Funding freeze at Northwestern from Emma Mairson at grant-watch.us. Data from USAspending. Normally, ~$70 M per month. Now, bupkis. Northwestern is keeping research moving and must be spending ~$40 M per month. Clearly not sustainable for too long.
All of NIH funding to Northwestern University is frozen. This pause includes noncompeting approved funding, new and competing grants with fundable scores. No reimbursements for money already spent have been received since March. This situation is rarely reported so please Please get the word out!
L’administration a mis à la porte un très grand nombre de scientifiques dans les agences fédérales. Celles et ceux qui restent se taisent et doivent censurer leurs travaux. Mais la mobilisation s’organise, avec une première mobilisation internationale vendredi 7 mars. Par Caroline Coq-Chodorge
Depuis les États-Unis de Trump, une vague obscurantiste s’abat sur la science
L’administration a mis à la porte un très grand nombre de scientifiques dans les agences fédérales. Celles et ceux qui restent se taisent et doivent censurer leurs travaux. Mais la mobilisation s’organise, avec une première mobilisation internationale vendredi 7 mars.
l.mediapart.fr
À Toulouse on prend le relais, départ 18h allées Jules Guesdes ! #StandUpForScience
Stand Up for Science Paris et région parisienne@sufs-paris-rp.bsky.social · last yr.Encore bravo pour cette mobilisation. Le combat pour les libertés académiques continue.
