Delighted to share our latest publication: "Long-term rapamycin treatment suppresses IL-17-producing γδ T cells and blunts neuroinflammation during ageing." A particularly meaningful paper for me as it marks my first senior author publication 🔗 journals.plos.org/plosone/arti...

Long-term rapamycin treatment suppresses IL-17-producing gamma delta T cells and blunts neuroinflammation in aging

Aging is the gradual accumulation of structural and functional changes in an organism over time, including immune remodeling and a progressive increase in basal inflammation, or inflammaging. The mTOR...

journals.plos.org

Delighted to share our latest publication from my postdoc @ki.se @bertrandjoseph.bsky.social 'Microglia in diffuse midline glioma contribute to extracellular matrix remodelling and cancer cell invasion' Thanks to all co-authors, DMG families and Barncancerfonden www.nature.com/articles/s41...

Fascinating new link between stress, liver tryptophan metabolism, and liver cancer in this new article @natmetabolism.nature.com www.nature.com/articles/s42... We unpack it in our Nature Metabolism News & Views with John Cryan & Gerard Clarke, have a read: rdcu.be/eZHvs

November issue now online www.nature.com/nri/volumes/... Cover art inspired by a Perspective article by @lilykeane.bsky.social, Gerard Clarke & @jfcryan.bsky.social on the role of microglia, the 'gardeners' of the brain, in modulating the gut-brain axis www.nature.com/articles/s41...

Happy to be in Liverpool for #BSI25 this week. On Wednesday I’ll be speaking about how microbiome–microglia communication influences brainstem development and contributes to diffuse midline glioma in the Neuroimmunolgy across the body session (Part2).

Last night we said goodbye to our brilliant postdoc Cristina Cuesta. It’s hard to see such an inspiring scientist and colleague move on, but we’re so proud to have been part of her journey. The future is bright for this rising star! 🌟

Very excited to see our latest perspective “A role for microglia in mediating the microbiota–gut–brain axis”, together with @jfcryan.bsky.social and Ger Clarke make the cover of NRI! @apcmicrobiomeirel.bsky.social @anatneuroucc.bsky.social @researchireland.ie

Nature Reviews Immunology@natrevimmunol.nature.com · 10mo ago

November issue now online www.nature.com/nri/volumes/... Cover art inspired by a Perspective article by @lilykeane.bsky.social, Gerard Clarke & @jfcryan.bsky.social on the role of microglia, the 'gardeners' of the brain, in modulating the gut-brain axis www.nature.com/articles/s41...

Attending the @helloeacr.bsky.social Cancer Neuroscience meeting in Bilbao, Spain today? Check out my PhD student @austejabaleviciute.bsky.social poster in this evenings session "Targerting Microglia in Diffuse Midline Glioma - heating up the Tumour Microenvironment'

Congratulations to my amazing postdoc Cristina Cuesta Martí for wining the @ecnp.eu excellence award for our work on how 'The early life microbiota shapes the development of the brainstem during a critical window of vulnerability to diffuse midline glioma' @jfcryan.bsky.social, Gerard Clarke

Looking forward to chairing this exciting symposium at @ecnp.eu Congress Amsterdam: Vascular function and cognitive health across the lifespan. Join us to hear from these excellent speakers on how vascular health shapes cognitive function. 🗓 Tuesday, October 14th | 08:40–10:00 📍 Elicium 1 #ECNP2025

What's new on gut–microglia communication for shaping microglia-related functions? This timely review addresses opportunities and clinical implications @jfcryan.bsky.social @lilykeane.bsky.social https://loom.ly/enYXCnc

A role for microglia in mediating the microbiota–gut–brain axis - Nature Reviews Immunology

This Perspective explores how the gut microbiota influences the function and heterogeneity of microglia, highlighting their roles in neurological and neuropsychiatric disorders, and discusses the therapeutic potential, challenges and clinical implications of targeting microbiota–microglia interactions.

nature.com

Incredibly honoured to receive prestigious @researchireland.ie funding to study developmental vulnerabilities in diffuse midline glioma (DIPG/DMG). Huge thanks to my amazing mentor @jfcryan.bsky.social Excited for what’s ahead! @apcmicrobiomeirel.bsky.social @anatneuroucc.bsky.social

Thrilled to see our review out in @natrevimmunol.nature.com together with my amazing mentors @jfcryan.bsky.social and Ger Clarke. @apcmicrobiomeirel.bsky.social @anatneuroucc.bsky.social @uccresearch.bsky.social www.nature.com/articles/s41...

A role for microglia in mediating the microbiota–gut–brain axis - Nature Reviews Immunology

This Perspective explores how the gut microbiota influences the function and heterogeneity of microglia, highlighting their roles in neurological and neuropsychiatric disorders, and discusses the ther...

nature.com

A Perspective article by @lilykeane.bsky.social, Gerard Clarke & @jfcryan.bsky.social @apcmicrobiomeirel.bsky.social proposes that microbiota–microglia cross-talk may have major implications for our understanding of neurological disorders and neuropsychiatric disease #immunosky #microsky #microbiome

A role for microglia in mediating the microbiota–gut–brain axis - Nature Reviews Immunology

This Perspective explores how the gut microbiota influences the function and heterogeneity of microglia, highlighting their roles in neurological and neuropsychiatric disorders, and discusses the ther...

nature.com

The Keane lab is hiring! Join our team at @apcmicrobiomeirel.bsky.social on an exciting new project trying to understand how the gut-brain axis shapes the tumour microenvironment of Diffuse Midline Glioma #cryanlab #DMG #DIPG Apply here using using Job Id 085551 ucc.ie/en/hr/vacanc...

Delighted to see our recent perspective in Trends in Molecular Medicine, part of @cellpress.bsky.social making the cover! In this perspective, we discuss the potential to exploit the gut microbiome to improve responses to current and novel brain tumour treatments. @jfcryan.bsky.social, Jack Gleeson

Latest lab review- The Gut microbiota-Immune-Brain axis: Therapeutic Implications. Just out in @cp-cellrepmed.bsky.social Well done @kjdoriordan.bsky.social @moloneyger.bsky.social & @lilykeane.bsky.social www.cell.com/cell-reports...

🎉 Huge congratulations to @roisinmcmanus.bsky.social and Michael Heneka on this exciting study uncovering a novel role for NLRP3 in regulating microglial metabolism and phagocytosis to promote Alzheimer’s disease progression www.cell.com/immunity/abs...

NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression

How NLRP3 impacts Alzheimer’s disease (AD) is unclear. McManus et al. find that NLRP3 is located at mitochondria where it regulates microglial metabolism. Depletion or chronic pharmacological inhibiti...

cell.com

Happy to be part of this new and exciting study from @bertrandjoseph.bsky.social lab @karolinskainst.bsky.social where we identify critical molecular determinants of microglial cellular aging, including SLC16A3 and P2RY13 www.nature.com/articles/s41...?

Age-associated microglial transcriptome leads to diminished immunogenicity and dysregulation of MCT4 and P2RY12/P2RY13 related functions

Cell Death Discovery - Age-associated microglial transcriptome leads to diminished immunogenicity and dysregulation of MCT4 and P2RY12/P2RY13 related functions

nature.com

Gavin's story lifts my heart. What an inspiration! www.seattlechildrens.org/research/fea...

CAR T Cell Therapy Offers Hope Against DIPG – Featured Research

Encouraging success from Seattle Children’s cancer doctor and researcher Nick Vitanza dosing CAR T cell therapy directly to brain for patients with DIPG.

seattlechildrens.org

So proud of @larswilmes.bsky.social or should I say Dr. Wilmes for successfully defending his PhD yesterday.

John F. Cryan@jfcryan.bsky.social · 2y ago

Huge congratulations to Dr. @larswilmes.bsky.social who successfully defended his PhD today - thanks to the examiners David Finn & ⁦‪Rachel Moloney for a great discussion. ⁦‪Ger Clarke‬⁩ & I are proud supervisors indeed. ⁦‪@apcmicrobiomeirel.bsky.social‬⁩