Lindsey Van Haute
@lindseyvanhaute.bsky.social
Next generation sequencing geek and mitochondria lover https://www.nextgenseqanalysis.com Check out my YouTube channel: https://www.youtube.com/@SimpleScienceLVH #RNA,#DNA,#mitochondria,#NGS #RNAseq,#Genomics,#bioinformatics,#equality
Study shows that mothers are: - 29% less likely to be employed at a university - 12% reduction in earnings when they left academia - 35% decline in their chance of getting tenure - 31% fewer publications than fathers www.nature.com/articles/d41...
Motherhood derails women’s academic careers — these data reveal how and why
Mothers in academia take on considerably more childcare-related responsibilities than do fathers.
nature.com
Friendly reminder from AI-Lindsey: ChatGPT isn’t ‘smart’, it’s obedient. If your prompt is fuzzy, your result will be… creative.
What factors contribute the most to PhD satisfaction? Stipends that are more than just a living wage? Manageable hours? A supportive team? These all matter, and are often in short supply. Another factor often overlooked is supportive supervision. www.nature.com/articles/d41...
What makes PhD students happy? Good supervision
Supervisors who invest in positive mentoring relationships with their PhD candidates also reap the benefits for their own research.
nature.com
Higher education is being reshaped by powerful forces — from AI to mental health to decolonization. Six scholars offer fresh ideas for how universities can truly evolve. www.nature.com/articles/d41...
Universities must move with the times: how six scholars tackle AI, mental health and more
Societies are evolving, and so must higher education. Researchers describe initiatives that can help to create stimulating and nurturing environments fit for today’s learning landscape.
nature.com
The rise in applications indicates a “huge increase in the amount and cost of work for academics completing these applications”. “[Researchers] must be spending less time either teaching or doing research, and spending more time on writing these grants”. www.nature.com/articles/d41...
The grant lottery: award rates at UK national funding agency fall below 20%
Application volume is outpacing available funding, intensifying competition and worsening pressure on the peer-review system. But those who win grants are now getting more.
nature.com
P-hacking Removing outliers, using alternative statistical methods and running extra experiments are some methods that could be used to change the P-value. Be careful not to fall in this trap! Stay sceptical! Null results are a normal part of science. www.nature.com/articles/d41...
P hacking — Five ways it could happen to you
Some data practices can lead to statistically dubious findings. Here’s how to avoid them.
nature.com
It was fantastic to have @labliston.bsky.social give a talk at the @mrc-mbu.bsky.social on building a positive research culture. Valuable for all investigators/group leaders regardless of career stage, check out the resources below: listonlab.uk/careers/
Translational Immunology - Careers
Becoming a Scientist
listonlab.uk
The temptation to create beautify images can be a slippery slope. www.nature.com/articles/d41...
The do’s and don’ts of scientific image editing
Acceptable image-editing practices are partly a matter of common sense. But researchers say journals and funders could help scientists by standardizing policies.
nature.com
Stem cells were initially touted as a cure-all, but aside from a few anecdotal studies, this has not been proven true. Is it finally going to happen? www.nature.com/articles/d41...
Japan’s big bet on stem-cell therapies might soon pay off with medical breakthroughs
Induced pluripotent stem cells are being tested to treat blindness, paralysis, Parkinson’s disease and more. Approvals might be around the corner.
nature.com
Clinically translatable mitochondrial #GeneTherapy in muscle using tandem mtZFN architecture. By P. Nash, @mitogene.bsky.social & colleagues @mrc-mbu.bsky.social 🗞️ doi.org/10.1038/s443... Read also related N&V by A. Ghifari & M. Ott 👉 doi.org/10.1038/s443...
Congratulations, Pavel! Proud to have been involved in this project.
Minczuk Lab@mitogene.bsky.social · last yr.Huge congrats to Pavel Nash on publishing his PhD work! 🎉 We showcase a safer mtDNA gene therapy using a novel mtZFN architecture compatible with a single AAV. Thanks to the entire team! @mrc-mbu.bsky.social @mbu-postdocs.bsky.social #MitochondrialDisease #mtDNA www.embopress.org/doi/full/10....
Reposting since it's been a while since I posted this, and new MBU members might have joined.
Lindsey Van Haute@lindseyvanhaute.bsky.social · 2y agoI thought connecting current and past members of MBU Mitochondrial Biology Unit Cambridge would be useful. Please note that this is a work in progress and that more people will be added. 🔄 Anyone missing? Additions welcome! go.bsky.app/9ATZngh
Mitochondria differ in type and density in different parts of the brain. For example, the evolutionarily oldest brain regions have a lower density of mitochondria than newer regions. www.nature.com/articles/d41...
First map of human brain mitochondria is ‘groundbreaking’ achievement
Hundreds of cubes of human brain tissue help scientists to chart the energy-making capabilities of various brain regions.
nature.com
Shared first authorship, but who gets to be first? According to this study, there is no disadvantage to sharing credit. Weakness of the study: The test name was a gender-neutral European name. Can someone please repeat this study with female/non-European names? www.nature.com/articles/d41...
Does sharing first authorship on a paper carry a penalty? What the research says
Study dispels myth that order of names in a paper’s author list dictates perception of success.
nature.com
In-cell architecture of the mitochondrial respiratory chain | Science www.science.org/doi/10.1126/...
In-cell architecture of the mitochondrial respiratory chain
Mitochondria regenerate adenosine triphosphate (ATP) through oxidative phosphorylation. This process is carried out by five membrane-bound complexes collectively known as the respiratory chain, workin...
science.org
“These findings will need to be confirmed in vivo.“ Animal research can be extremely valuable, but isn't it time to encourage novel alternative non-animal models if they are available? Shouldn't funders encourage research to establish such alternative models more? www.nature.com/articles/d41...
How ‘animal methods bias’ is affecting research careers
Some early-career researchers report feeling pressure to use animal models to meet journal and grant requirements, even in disciplines and projects that don’t require them.
nature.com
It is often said that the first responsibility of any government is the safety and protection of its people. Vaccines save lives, and casting doubt on their safety could have dangerous and far-reaching consequences. www.nature.com/articles/d41...
Vaccines save lives. Leaders must champion them
Attacks on vaccines and the cancellation of research into what causes vaccine hesitancy puts people in harm’s way.
nature.com
Can internet use become addictive? A #SciencePerspective discusses the addictive potential of the #internet and how it can be best conceptualized and evaluated. scim.ag/3R5Npv1 #BrainAwarenessWeek
Conference alert: Machines acting on DNA and RNA Madrid, May 28-30 Abstract deadline: April 24 Organised by @cniostopcancer.bsky.social. Come to share your research with experts in the molecular mechanisms of DNA & RNA machines. See the list of speakers below. Please repost.
Thought that only purine nucleotides could inhibit mitochondrial thermogenesis in brown adipose tissue? Edmund Kunji and coworkers @mitocarriers.bsky.social @mrc-mbu.bsky.social show that pyrimidines bind and inhibit UCP1 in similar manner www.embopress.org/doi/full/10....
Today is World Kidney Day. Are you sure your kidneys are OK? Do the quick test in the link and read about the risks. www.worldkidneyday.org/2025-campaign/
2025 campaign - World Kidney Day 2025
World Kidney Day – 13 March 2025 Are Your Kidneys OK?Detect early, protectkidney health Are Your Kidneys OK? Take this quiz! Are Your Kidneys OK? Detect early, protect kidney health Chronic kidney dis...
worldkidneyday.org
Alcohol raises the risk of at least seven types of cancer, including breast, liver, and esophageal cancer. Yet, many drinkers remain unaware. Is there truly a “safe” amount of alcohol? Would a cancer warning label be helpful? htps://www.nature.com/articles/d41586-025-00729-5
Alcohol and cancer risk: what you need to know
Experts weigh in on the risks of moderate drinking — and how people should assess them.
nature.com
"I had spent half my life working toward my dream of being a scientist. It had given me a sense of purpose. But now it dawned on me that, for the sake of my health, I was going to have to let that dream go." This week's #ScienceWorkingLife. scim.ag/4bCwyth
