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RyanLab_TCD

@ryanlab.bsky.social

Assistant Professor in Trinity College Dublin. A mitochondria and immunometabolism enthusiast. Views my own. 🇮🇪

267 Posts1225 Follower1071 Folgt
Trends in Endocrinology and Metabolism@cp-trendsendomet.bsky.social · last mo.

Online Now: Mitochondria produce lactate to vent redox pressure #trends #endocrinology #metabolism

Mitochondria produce lactate to vent redox pressure

Conventionally viewed as a waste product or a cytosolic pyruvate source, recent findings suggest that lactate may also directly contribute to mitochondrial oxidative metabolism. Using an intramitochondrial lactate biosensor, Rauseo et al. instead find that energized mitochondria are producers of lactate, which buffers mitochondrial redox to mitigate reactive oxygen species production.

dlvr.it

Catalina Vasilescu, PhD@cvasilescu.bsky.social · 2mo ago

New selection of papers on #Mitochondria in #Health & #Disease! 📚 biomed.news/bims-mitdis/... Mitochondrial l-2-hydroxyglutarate is a physiological [..] metabolite www.nature.com/articles/s41... @biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social @mito-news.bsky.social

Mitochondrial l-2-hydroxyglutarate is a physiological signalling metabolite - Nature

l-2-Hydroxyglutarate is identified as a legitimate physiological signalling metabolite, and control of its levels is essential for postnatal growth and survival and correct renal development and funct...

nature.com

Cell Chemical Biology@cp-cellchembiol.bsky.social · 3mo ago

Identification of an STING inhibitor targeting the allosteric transmembrane domains

Identification of an STING inhibitor targeting the allosteric transmembrane domains

Chen et al. introduce Y-320, a potent allosteric STING inhibitor that uniquely binds to the transmembrane domain instead of the canonical binding pocket, thereby blocking STING activation and trafficking. Y-320 effectively improves acute kidney injury in mice, highlighting the therapeutic potential of targeting non-canonical STING sites.

dlvr.it

RyanLab_TCD@ryanlab.bsky.social · 3mo ago

🚨 We’re hiring! 🚨 1/n I’m excited to share that the Ryan Lab at Trinity College Dublin is recruiting a Research Assistant to join our new team in the School of Biochemistry and Immunology, based inTBSI.☘️ Please share widely and see below for app details ⬇️

Jenny Difficult-Frecklington-Jones #IStandWithPalestine🍉🍉@joneshowdareyou.bsky.social · 3mo ago

“In my lifetime I have witnessed a terrible decline. In yours, you could and should witness a wonderful recovery.” What an immense privilege it has been to be alive at the same time as this incredible human being—David Attenborough. #Happy100thBirthday🥳 www.theguardian.com/tv-and-radio...

‘The greatest ambassador for life on Earth’: Tributes paid to David Attenborough on his 100th birthday

Naturalist says he has been ‘overwhelmed by greetings’ as milestone is marked with event at Royal Albert Hall

theguardian.com

RyanLab_TCD@ryanlab.bsky.social · 3mo ago

I’m delighted to share this news and grateful to the @wellcometrust.bsky.social for supporting our work. We will soon be recruiting for both a Research Associate and Research Assistant position. More details will follow shortly, but please feel free to get in touch! www.tcd.ie/news_events/...

Trinity scientist aims to demystify debilitating inherited conditions and pinpoint new treatment options

Dr Dylan Ryan will pursue the research after securing a highly competitive Wellcome Career Development Award valued at around €2.5 million.

tcd.ie

Magdalena Skipper@magdalenaskipper.bsky.social · 4mo ago

Is there life on Mars? Organic molecules from clay-bearing sandstones found by the Sample Analysis at Mars instrument suite onboard the Curiosity rover 🧪 @natcomms.nature.com www.nature.com/articles/s41...

Diverse organic molecules on Mars revealed by the first SAM TMAH experiment - Nature Communications

Curiosity detected over 20 organic molecules in 3.5-billion-year-old Martian rocks using a wet chemistry experiment, showing complex carbon compounds can survive for billions of years and may preserve...

nature.com

Ivan Zanoni@lozanzi.bsky.social · 4mo ago

#WeekendRead! #SharingIsCaring! #CatchMeIfYouCan! Roska, Ayupov, Moreno-Juan &co show @nature.com that healthy #mitochondria can be efficiently delivered to distinct cell types via a selective #MitoCatch system that allows their intracellular transfer & protection of cells!

Cell-type-targeted mitochondrial transplantation rescues cell degeneration - Nature

MitoCatch is a cell-type-specific mitochondrion-targeting system that links mitochondria and the cell surface by protein binders and delivers mitochondria into the target cell.

nature.com

Nature Portfolio@natureportfolio.nature.com · 4mo ago

In its 2025 PhD survey, Nature asked more than 3,700 doctoral candidates around the world a simple question: what is the best thing your supervisor has done for you during your studies? Nature highlights several moments when good supervision made the difference. #Academicsky 🧪

14 things our PhD supervisors got right and why it mattered

PhD students reflect on how their supervisors made a meaningful difference — from quiet acts of kindness to career-shaping guidance.

go.nature.com