Our workflow to image and analyse germinal centres using a 50-plex cyclic staining protocol now out. Work led by Isabel San Martín Molina & Edith Marcial Juárez with @babrahaminst.bsky.social imaging facility scientists Simon Walker & Hanneke Okkenhaug. onlinelibrary.wiley.com/doi/10.1002/...

Spatial Profiling of Germinal Centers in Mouse Secondary Lymphoid Organs Using MACSima Imaging Cyclic Staining Technology

We developed a 50-plex imaging protocol using the MACSima platform to characterize the microarchitecture of germinal centers in secondary lymphoid tissues. This workflow combines tissue processing, a...

onlinelibrary.wiley.com

It's not too late to join us for Lorne I&I 2026! We have an incredible line-up of stellar Invited Speakers joining us from interstate and across the globe; check out our live Program for more details. Don't miss out, register now! www.lorneinfectionimmunity.org/registration #lorneiandi

Ever wondered what happens if you remove Tfh cells from established germinal centres?

Thanks for highlighting our work 🙏 Project led by Louise Webb @babrahaminst.bsky.social

Waggoner Lab@labwaggoner.bsky.social · 6mo ago

Germinal center responses can recover from transient loss of T cell help, but the sustained reduction in TFH cells impairs recall responses @sciimmunology.bsky.social www.science.org/doi/10.1126/... @babrahaminst.bsky.social @linterman.bsky.social

Thank you Fiamma. So good to be at LUMC and the NVVI this week. Great science, and great company!

Fiamma Salerno@fiammasalerno.bsky.social · 8mo ago

What a joy to host Michelle @linterman.bsky.social at the LUMC and spend more time together at the #NVVI!! She shared wonderful work on ectopic Germinal Centers in the lung (www.pnas.org/doi/10.1073/...) and a new exciting story that I can't wait to see published soon!!

Great to have this out, and such a pleasure to work together. @smguillaume.bsky.social @cristianbeccaria.bsky.social @iannaconelab.bsky.social

Cristian G Beccaria@cristianbeccaria.bsky.social · 10mo ago

So happy to share that our review in #ImmunolRev is finally out! 😃 We discuss how the immune system builds specialized TLSs across organs and conditions. Huge thanks to @StephanGuillaume, @iannaconelab.bsky.social & @linterman.bsky.social for this collaboration! dx.doi.org/10.1111/imr.70063

Save the date! Keystone Stromal Immunology meeting, Feb 2-5, 2026 #KSStromal26 1. Scholarships/Short Talk Abstracts: October 7 2. Early Registration: December 3 (Save $200!) 3. Poster Abstracts: January 12, 2026 (11:59 MST) Please share! And reach out if you have any questions. Can't wait!

It was great to be back at the @babrahaminst.bsky.social this week to spend time with the team talking about our science, and even managed a (very well timed) paper celebration! Amazing Tfh/GC themed brownie from Jess James.

Thank you @immunologyking.bsky.social & @maurogaya.bsky.social for organising the #EMBObarrierTissues meeting in Basel this week. Great science, great people, great atmosphere ❤️

Thank you Diana! Credit to @smguillaume.bsky.social for leading this work. Lung B cells in ectopic germinal centers undergo affinity maturation | PNAS share.google/6zXPfzAaAcva...

Lung B cells in ectopic germinal centers undergo affinity maturation | PNAS

The lungs are constantly exposed to the external environment and a myriad of antigenic challenges within the air. Chronic exposure to allergens and...

share.google

Diana E Matei@dianaematei.bsky.social · 11mo ago

@pallettlab.bsky.social showing exciting new data on liver TRMs @linterman.bsky.social with great insights into lung GC B cells (yes actual lung GC!) @carlanowosad.bsky.social showing such pretty confetti GCs along with an amazing analogy for LN organisation and concerts in stadiums 😅 🤩👏

Beautiful talk from @mahimaswamy.bsky.social at #EMBObarrierTissues. Conserved developmental rewiring of the TCR signalosome drives tolerance in innate-like lymphocytes | bioRxiv share.google/UroEHTZJI7tk...

Conserved developmental rewiring of the TCR signalosome drives tolerance in innate-like lymphocytes

Natural intraepithelial T lymphocytes (T-IELs) are innate-like, intestine-resident T cells essential for gut homeostasis. These cells express self-reactive T cell antigen receptors (TCRs) due to thymi...

share.google

Fantastic @embo.org young investigator lecture on lung B cell responses from @maurogaya.bsky.social #EMBObarrierTissues

Thank you Cris 🙏 Credit to Alyssa Silva Cayetano and Theresa Pankhurst for leading these research projects

Cristian G Beccaria@cristianbeccaria.bsky.social · 12mo ago

Amazing talk by Michelle @linterman.bsky.social at @iuis-online.bsky.social 2025 on ageing and immune responses to vaccines, shedding light on how understanding these mechanisms can guide the development of better immunization strategies

Absolutely fantastic to have @labliston.bsky.social visiting the @malaghan.bsky.social this week. Beautiful talk on harnessing the power of Tregs to promote tissue repair, as well as many scientific discussions, an award ceremony at @nzparliament.bsky.social and multiple runs up our hills!

A pleasure to have you in Aotearoa New Zealand to celebrate science!

Adrian Liston@labliston.bsky.social · 12mo ago

Great event at @nzparliament.bsky.social for Medicines New Zealand, with lots of exciting innovations in medical research on display. Thanks to @linterman.bsky.social from @malaghan.bsky.social for the invite!

Fantastic to have Johanne Jacobsen at @malaghan.bsky.social this week presenting her beautiful work on germinal centre T cells, in all their complexity.

Finally, after moving halfway across the world to beautiful Aotearoa New Zealand, our (Italian) espresso machine has arrived. Even better that we can get tasty beans from Acme who also make a special @malaghan.bsky.social blend that supports our research ❤️ lnkd.in/gbWi6RuW

Great to have the @jimmunol.bsky.social special collection, “Aging's impact on the immune system” out. academic.oup.com/jimmunol/pag...

Aging's impact on the immune system

Description This 2025 collection of The Journal of Immunology features a special collection of articles curated by guest editor Patricia Gearhart. The collecti

academic.oup.com

Highlights of 2024: unleashing the power of NK cells—cancer's worst nightmare onlinelibrary.wiley.com/doi/10.1111/...

🚨🦠🔬 Last month to register to the EMBO workshop on Adaptive Immunity in Barrier Tissues. 📍 Where: Basel, Switzerland 📅 When: 26th–29th August 2025 📝 Registration deadline: 30th May 2025 Childcare support & travel grants from @embo.org and @efis-immunology.bsky.social #EMBOBarrierTissues

Adaptive immunity in barrier tissues

Immune responses lie at the heart of almost every aspect of human health, including host responses to infection, autoimmunity, cancer, metabolism and aging. While adaptive immune responses by B and T…

meetings.embo.org

Our @immunolcellbiol.bsky.social "Highlights of 2024: Germinal Centers" is now out. Led by Theresa Pankhurst, we discuss some (there's never enough space for all!) neat germinal centre papers that were published in 2024, and whose findings are moving the field forward. doi.org/10.1111/imcb...

<em>Immunology & Cell Biology</em> | ASI Journal | Wiley Online Library

In this article for the Highlights of 2024 series, we review the latest advances in the biology of the germinal center response. These discoveries provide key insights into germinal center function a...

doi.org

Can't wait! I'm really looking forward to this meeting, so many amazing talks. Thanks @maurogaya.bsky.social @immunologyking.bsky.social @embo.org for organising ❤️ #EMBOBarrierTissues

Mauro Gaya@maurogaya.bsky.social · last yr.

Dr. Michelle Linterman from the Malaghan/Babraham Institutes 🇳🇿🇬🇧 will be presenting her work on "Function and maintenance of lung germinal centres". Check her recent study on how lung B cells undergo affinity maturation: pubmed.ncbi.nlm.nih.gov/40168127/ @linterman.bsky.social #EMBOBarrierTissues

Neat @pnas.org paper from @angelettilab.bsky.social & @matsbemark.bsky.social on ectopic germinal centres in the nasal turbinates of mice and humans. doi.org/10.1073/pnas...

Ectopic germinal centers in the nasal turbinates contribute to B cell immunity to intranasal viral infection and vaccination | PNAS

The nasal mucosa is the first immunologically active site that respiratory viruses encounter and establishing immunity at the initial point of path...

doi.org

Thank you for the @thelisterinstitute.bsky.social support for this project! We couldn't have done it without you.

The Lister Institute of Preventive Medicine@thelisterinstitute.bsky.social · last yr.

A new paper from #ListerFellow @linterman.bsky.social and colleagues explores the role of tertiary lymphoid structures (TLS) in #bcell immune response. @pnas.org doi.org/10.1073/pnas...

Lung B cells in ectopic germinal centers undergo affinity maturation www.pnas.org/doi/10.1073/... @linterman.bsky.social @smguillaume.bsky.social @wsfoster.bsky.social @sanmarti92.bsky.social @emae-watson.bsky.social

Michelle Linterman@linterman.bsky.social · last yr.

Great to have our paper out in @pnas.org showing that lung B cells in ectopic germinal centers undergo affinity maturation. @smguillaume.bsky.social @wsfoster.bsky.social @sanmarti92.bsky.social @emae-watson.bsky.social Silvia Innocentin, Grant Kennedy & Alice Denton. doi.org/10.1073/pnas...

Great to have our paper out in @pnas.org showing that lung B cells in ectopic germinal centers undergo affinity maturation. @smguillaume.bsky.social @wsfoster.bsky.social @sanmarti92.bsky.social @emae-watson.bsky.social Silvia Innocentin, Grant Kennedy & Alice Denton. doi.org/10.1073/pnas...

Lung B cells in ectopic germinal centers undergo affinity maturation | PNAS

The lungs are constantly exposed to the external environment and a myriad of antigenic challenges within the air. Chronic exposure to allergens and...

doi.org

Thanks to @zanivanlab.bsky.social , Max Mazzone and the Forbeck Research Foundation for a fantastic Forum on Harnessing stroma immune interactions for anti-cancer therapy. I learnt a huge amount from the participants and all the discussion. www.forbeckforums.org/forums/harne...

Great to have our latest review "The cellular factors that impair the germinal center in advanced age" out @jimmunol.bsky.social. Work led by @wsfoster.bsky.social and Edith Marcial-Juárez. With @sanmarti92.bsky.social creating the beautiful GC images in figure 2. doi.org/10.1093/jimm...

Thanks for highlighting our work. Credit goes to @wsfoster.bsky.social and Edith Marcial-Juárez for bringing this together

Thanks for the shout out. Credit to William Foster and Edith Marcial-Juárez for leading on this review.

Prof John Gordon@profcelentyx.bsky.social · last yr.

Terrific #ImmunoAgeing Review @jimmunol.bsky.social from @linterman.bsky.social & friends @babrahaminst.bsky.social "Thanks for the #Memory" #Bcells #GerminalCenter #Immunity #Infection #Vaccination #Antibodies