Lothar Kalmbach

@lkalmbach.bsky.social

🌱 Assistant Professor at Uni of Neuchatel 🇨🇭 Investigating plant cell walls, vasculature, and physiology.

“Seven days after the girl’s medical team infused trillions of viruses carrying the recipe for the base editor into her spinal fluid, she died of a severe immune reaction linked to the therapy…” This, in @science.org, is an important and tragic story. (It’s also an incredibly well reported one.) 🧪

Exclusive: Death of girl in Chinese gene-editing trial was never made public

Parents want accountability after study went disastrously wrong, Science and Retraction Watch investigation reveals

science.org

We’re looking for a postdoc to identify polarity determining factors in bundle sheath cells of C4 grasses and their role in the carbon concentrating mechanism. @johninnescentre.bsky.social Applications close 15th June. Please check out the job ad below or get in touch! #PlantSciJobs

John Innes Centre@johninnescentre.bsky.social · 3mo ago

An exciting opportunity to join Dr Schreier's new group as a postdoctoral researcher is open for applications until 15 June 2026: www.jic.ac.uk/vacancies/po...

Plasmodesmal closure triggers stress responses! Turns out cells are generally better off with connections to their neighbours. This manuscript represents a decade-long team collaboration, with heroic effort from Estee Tee to lead it over the line! #PlantScience link.springer.com/article/10.1...

Plasmodesmal closure elicits stress responses - EMBO Reports

Plant cells are connected to their neighbors via plasmodesmata facilitating the exchange of nutrients and signaling molecules. During immune responses, plasmodesmata close, but how this contributes to...

link.springer.com

Our first study on how the leaf succulent Kalanchoë laxiflora makes stomatal subsidiary cells is finally peer-reviewed & out - and it made the cover! 🌵 🧬 🔬 doi.org/10.1126/scia... Despite 150 years of evolution, grasses and Crassulacean succulents use the SAME gene to make subsidiary cells! 🤯

ONLINE COVER: Leaves of Kalanchoe thyrsiflora, a member of the Crassulaceae family of succulents also containing Kalanchoë laxiflora. Stomata, otherwise known as plants’ breathing pores, allow gas exchange between plants and the atmosphere, but little is known about how succulent stomata are formed or move. Cheng et al.’s investigation into K. laxiflora revealed that subsidiary cells can support the opening and closing of stomata and that the transcription factor MUTE, which drives stomatal development, also facilitates additional rounds of asymmetric division needed to generate subsidiary cells. Their work provides insight into succulent development and could be applied in agricultural contexts to engineer water conservation strategies.

Credit: Rob Tilley / MindenExcessive activation of the MUTE gene switch leads to unrestricted asymmetric cell divisions in the leaf surface of the succulent Kalanchoë laxiflora.
© Miro LäderachThe MUTE gene switch is active in all cells of the developing stomata. Gene activity is visible through a weak signal (in blue) in the future helper cells and a strong signal (in green) in the mother cell of the guard cells.
© Michael Raissig
Michael Raissig@michaelraissig.bsky.social · 2y ago

🌵Preprint alert 🌵 5y in the works & extremely proud of this one. Xin Cheng & @heikelindner.bsky.social established the eudicot leaf succulent Kalanchoë laxiflora as a dev model. Like in grasses, MUTE makes Kalanchoë’s stomatal subsidiary cells! 1/n www.biorxiv.org/content/10.1... BSKY-tutorial 👇