On this day in 1944, the Gestapo found Anne Frank and her family in their Secret Annex. Her diary stands as a warning against hatred and persecution. Eighty years later, we should recognize the warning signs before it’s too late.🙂‍↕️

New preprint! In collaboration with the Yogev lab (Yale), we characterized and determined structures of various gamma-tubulin complexes from C. elegans, showing how divergent worm subunits evolved to template non-canonical (11-pf) and possibly canonical (13-pf!) microtubules: tinyurl.com/2sapyx2b

Monday: Train cancelled because too many trains need repair. Tuesday: Train cancelled because too many trains need repair. Wednesday: Train delayed because another train broke down. Almost 10% cancellations and just barely more than 70% on time is “not great”. Back to more maintenance, I guess.

Out now! In collaboration with Hiroshi Nishimasu's lab, we uncover how a dual reverse transcriptase immune system builds double-stranded DNA from both RNA and protein templates. www.cell.com/cell/abstrac... Previous thread for the preprint: bsky.app/profile/ster...

Coordinated RNA- and protein-templated synthesis of double-stranded DNA by a dual reverse transcriptase immune system

Bacterial reverse transcriptases defend against viruses, yet how their DNA products stop infection remains unknown. Bacteriophage inhibition of a host recombination enzyme activates the DRT3 defense s...

cell.com

🚀 New preprint 🥳 Fantastic work by our recent PhD graduate Daan ! How are mRNPs remodeled as they exit the nucleus? We identify PAIP1 as a factor that promotes exchange of the nuclear poly(A)-binding protein PABPN1 for cytoplasmic PABPC1, coupling mRNA export to cytoplasmic mRNP maturation.

bioRxiv Molecular Biology@biorxiv-molbio.bsky.social · 2d ago

PAIP1 couples mRNA export to cytoplasmic mRNP remodeling and poly(A) homeostasis https://www.biorxiv.org/content/10.64898/2026.07.31.742013v1

"f you are hunting for a COVID villain[,] investigate crooks who promoted quack remedies...sources of anti-vaccine disinformation...No mistakes by the scientific community begin to compare with the [right's] brutal indifference to the well-being of Americans" www.theatlantic.com/ideas/2026/0...?

Anthony Fauci Is Not the Villain in This Story

The doctor was thrust into his pandemic-leadership role because of Trump’s deadly dereliction of duty.

theatlantic.com

The E of E. coli fame. I did not know this story - fascinating! #IDSky #Microsky

c0nc0rdance@c0nc0rdance.bsky.social · 4d ago

The headlines are still covering the cyclosporiasis outbreak from lettuce, but let's talk about a different summer, long ago. The headlines in Bavaria would have called it "summer diarrhea" & it was killing babies. Enter our hero, Professor Theodor Escherich of the Julius Hospital, Würzburg.

👀

James Woodfield@jameswoodfield.bsky.social · 4d ago

According to the parliamentary annual report & accounts for the 2025/26 financial year, the cost of subsidising the bars in the House of Commons alone was around £5.8 million. Meanwhile, to save £3 million less than that, Jodrell Bank is being defunded and shut down. share.google/MRHIvCsCsKoc...

just incredible to watch the US president take Iran's side when my state's water systems are under cyberattack

"A US government map of Africa mislabeled every country during a state department presentation at a global conference in Brazil this week, causing a stir among attenders who took screenshots and posted them online."

US government map of Africa mislabels every country at global conference

State department ‘takes full responsibility’ for erroneous, widely shared chart displayed at Aids conference in Brazil

theguardian.com

I love capturing those moments where London Underground trains line up perfectly with station posters. With a little patience and a bit of luck, you can end up with some wonderfully amusing and unexpected shots.

Great to see this finally published! We describe channels at the poxvirus core wall involved in nucleic acid release. www.nature.com/articles/s41...

In situ structure of the poxvirus portal complex - Nature

Cryo-electron tomography uncovers the structure of a conserved hexameric ‘portal complex’ that spans the core wall in vaccinia virus, and shows how it is associated with viral functions such as a...

nature.com

Very important work supporting our scientific community! So, do apply! And also: Do look at our pretty structure! 😀

EMDB@emdatabank.bsky.social · 6d ago

Closing this weekend! Join us as a scientific biocurator in the OneDep biocuration team. Work with structural data, software and processes that support data deposition and curation. Apply by 2nd Aug: tinyurl.com/47t93kxp. CAK-CDK1-Cyclin-B1: Timing is everything (#cryoEM EMD-54971).

“The report assiduously ignores that a symbiotic, profitable relationship between the federal government, universities, and private companies already exists. Each federal research dollar generates about $1.50 to $3.00 in long-term economic benefits.“ 🧪

Aaron Rupar@atrupar.com · 6d ago

New in PN: The new "science golden age" looks suspiciously like a grift "It’s impossible not to wonder whether part of Trump’s loathing for universities is that there's no way for him to corrupt the process and make money off it in the same way he can by giving billions to Silicon Valley types."

Rand Paul swiftly moved from wet markets to "natural immunity". Rambling. Quoting Martin Kulldorff. Time to post one of my favorite xkcd drawings xkcd.com/2557/ ▫️42/ #faucihearing

In which we share News (and our Views) on breakthrough work from the labs of @juanmartin-serrano.bsky.social, Wes Sundquist and Adam Frost. A protective ESCRT sleeve for ultrafine DNA bridges! Fun writing with @barrallabeth.bsky.social. @natsmb.nature.com doi.org/10.1038/s415...

Job alert: Receptors respond to important signalling molecules (#cryoEM EMD-27634) - Our biocurators work directly with scientists to ensure their data are ready for release. Communication is key. Come join the EMDB and OneDep biocuration team. Apply by 2nd Aug: tinyurl.com/47t93kxp

JFC. www.science.org/content/arti...

Exclusive: Death of girl in Chinese gene-editing trial was never made public

Parents want accountability after study went disastrously wrong, Science and Retraction Watch investigation reveals

science.org

Growing up in the Northwest, Jodrell Bank helped inspire my interest in science. To hear of its funding being cut by @ukri.org is extremely sad, and an act of monumental vandalism that diminishes UK science in so many ways, including its ability to excite little kids... www.bbc.co.uk/news/article...

Jodrell Bank's Lovell telescope faces axe in science cuts, BBC understands

Astronomers warn it would tear the heart out of UK science, and leave a generation untrained.

bbc.co.uk

Billionaire logic is that it makes more sense to terraform Mars rather than to stop venusifying Earth, and that it is a better strategy to build underground bunkers than to make the whole planet a better place to live for everyone.

But the press didn't walk out ... because most of them are spineless. If the press had done their job, rather than apply wildly different standards to Democrats, Trump would not have been in the White House the first time. The email lady would have run the U.S. with competence and integrity.

Can you imagine the shitstorm if this had been done by a democratic president?! This is not a functioning Republic.

David Ho@davidho.bsky.social · 2w ago

The Trump regime admitted to canceling over $7.5 billion in federal grants for clean energy projects in states that voted for Kamala Harris in the 2024 election.

This is insane. Read this thread.

Kathleen Bachynski@bachynski.bsky.social · 2w ago

“The committee ended the day by voting in favor of injectable TB-500, a peptide that, according to the F.D.A., was initially developed as a veterinary drug to boost performance in horse or greyhound racing.” IT HAS NOT PREVIOUSLY BEEN STUDIED IN HUMANS. THIS IS NOT ACCEPTABLE.

My inaugural lecture on July 6 was an unforgettable occasion, made so special by the presence of family, friends, colleagues, and my amazing lab members, past, present, and perhaps future. I am deeply grateful to everyone who joined and helped make the day so memorable. hdl.handle.net/1887/4307045

Happy that our most recent paper on nucleotide excision repair mechanisms has now been published in Science Advances. This project was led by @natalia-mg.bsky.social and @callumhaste.bsky.social and focused on visualising early steps of the NER process by #cryoEM. www.science.org/doi/10.1126/...

Visualization of stepwise derepression of TFIIH in global genome nucleotide excision repair

Cryogenic electron microscopy captures nucleotide excision repair complexes assembling on damaged DNA templates.

science.org

Glad that our deposited datasets are serving their intended purpose. It will be interesting to see how much the interpretability of the ligands has improved once the maps are available for inspection.

Structura Biotechnology@structurabio.bsky.social · 2w ago

🚀 Can automation solve preferred orientation in your #cryoEM datasets? After automating processing across 21 GPCR datasets in #CryoSPARC, we updated the workflow to be even more robust to preferred orientation, achieving improved map quality over manual processing. Read more 👉 bit.ly/3RyOIGG

👀

Guardian US@us.theguardian.com · 2w ago

An electric ice-cream maker was listed at just $17.99 at Amazon and Best Buy. Then it became unavailable at Best Buy, and more than tripled in price to $59.99 at Amazon. Here’s how it happened… 🧵

Overall, this settlement seems decent, but I still can't believe that the judge ruled that chewing up entire books is "fair use." How does that make sense, when as an author and teacher I can only use small portions of other's work in my work? apnews.com/article/ai-a...

Judge approves a $1.5B Anthropic settlement over pirated books used to train the Claude chatbot

A federal judge has approved a $1.5 billion copyright settlement involving AI company Anthropic. The company will pay thousands of authors about $3,000 per book for using pirated copies to train its C...

apnews.com

Thrilled to share our collab led by Grace Hibshman with the Shipman lab! Type IX retron-Kva2 structure reveals phage detection via an HTH fold, not a primary sequence. We computationally designed triggers that program bacteria cell death, pointing toward designer antimicrobials.