Excited to present our work on molecular glue degraders at the SMR Target to Patient conference in the Wellcome Genome Campus next month - looks like a very strong line-up. www.smr.org.uk/Meetings/202... #TargetedProteinDegradation #InducedProximity #MolecularGlues #DrugDiscovery #ChemicalBiology
SMR
smr.org.uk
Society for Medicines Research@socmedres.bsky.social · 6mo agoI’m taking steps to defy cancer at the Jimmy Fund Walk. Every donation to my walk will make an impact on the lives of patients and families at Dana-Farber. #JimmyFundWalk danafarber.jimmyfund.org/site/TR?fr_i...
I am walking for Dana-Farber patients
Together against cancer at the Jimmy Fund Walk
danafarber.jimmyfund.org
We’re excited to announce that nominations for our 2026 Emerging Investigator Lectureship are now open📢 Details about how to nominate: www.rsc.org/standards-an... We’re looking for up-and-coming researchers in drug discovery within 12 yrs of their PhD. Nominate before 31 October 2025! #chemsky 🧪
Who do you think has made an impact as a lifetime ambassador for nature? Nominate them for the Linnean Medal for Advocacy. The award recognises an exceptional track record in raising public awareness and advocating for the protection of nature. Submit a nomination by 30 September.
The Linnean Medal for Advocacy
An awarded to scientists for an outstanding contribution to the natural sciences.
buff.ly
🔓Check out this #OpenAccess article by @labthoma.bsky.social and colleagues where they investigated the potential of niclosamide as a molecular glue degrader targeting the proto-oncogene cyclin D1👀🔥 pubs.rsc.org/en/content/a... 📍EPFL, @fmiscience.bsky.social 🧪
Niclosamide: CRL4AMBRA1 mediated degradation of cyclin D1 following mitochondrial membrane depolarization
Targeted protein degradation has emerged as a promising approach in drug discovery, utilizing small molecules like molecular glue degraders to harness the ubiquitin-proteasome pathway for selective…
pubs.rsc.org
We're hiring postdoctorate fellows in covalent chemical biology - pass the word. careers.dana-farber.org/job/11940/po... careers.dana-farber.org/job/11941/po...
Fellowships Job: Postdoctoral Research Fellow - Jones Lab Chemistry at Dana-Farber Cancer Institute in 450 Brookline Ave, Boston, MA
Postdoctoral Research Fellow - Jones Lab Chemistry job
careers.dana-farber.org
📢We are delighted to share our latest themed collection on Induced-Proximity Pharmacology, guest edited by @lynjoneschembio.bsky.social, @hartungingo.bsky.social & Lindsey James! Explore the articles that make up this fantastic collection, here👇 pubs.rsc.org/en/journals/... #chemsky 🧪
Next up in the RSC Medicinal Chemistry Editor's Choice collection are Sankar Guchhait's chosen articles! Be sure to read our blog to see what he chose and why 👉 blogs.rsc.org/md/2025/06/1... And scan the QR code to see our collection as it grows👀
Splice modulators, meet your match. 🔦 Using photoaffinity labeling + Chem-CLIP, researchers mapped small molecule–RNA binding across the transcriptome and found... telomerase?! Wild. Read the study: doi.org/10.1039/D4CB...
Photoaffinity enabled transcriptome-wide identification of splice modulating small molecule–RNA binding events in native cells
Splice modulating small molecules have been developed to promote the U1 snRNP to engage with pre-mRNAs with strong and altered sequence preference. Transcriptomic profiling of bulk RNA from compound treated cells enables detection of RNAs impacted; however, it is difficult to delineate whether transcriptional chang
doi.org
We are delighted to announce that our 2024 Emerging Investigators collection is now online👀 This themed collection aims to highlight the achievements of some early career researchers in the medicinal chemistry community. Access it here👉 pubs.rsc.org/en/journals/... #Chemsky🧪
Darwin's grandfather was known for writing somewhat scandalous, Linnaeus-inspired poetry about the reproductive habits of plants. This #WorldPoetryDay we present you with this excerpt about the mythical #VegetableLamb without further comment.
📣 Last chance to register! The 2nd SMR Molecular Glues Meeting - 21st March 2025 🚀🚀🚀 🌟 World-class Speakers 🌟 Cutting-edge Insights 🌟 Networking Opportunities 📅 Date: 21st March 2025 📍 Location: GSK Stevenage, UK 🔗 Register here: www.smr.org.uk/Meetings/202...
Still hopping for more frog content? A paper published in the Zoological Journal of the Linnean Society highlights a new(ish) species of proto-amphibian named after the universally beloved celebrity, #Kermit the Frog. @zoojlinnsoc.bsky.social academic.oup.com/zoolinnean/a...
kermit the frog from the muppet show is standing in front of a red curtain
ALT: kermit the frog from the muppet show is standing in front of a red curtain
media.tenor.com
📢We are delighted to announce that Michael Bollong (@scripps.edu) has been awarded the 2025 RSC Medicinal Chemistry Emerging Investigator Lectureship🎉 Join us in congratulating Michael and read our blog to find out more about him and his work: blogs.rsc.org/md/2025/01/3... #Chemsky 🧪
Issue 3 is now online and ready to read👇 pubs.rsc.org/en/journals/journalissues/md#!issueid=md016003&type=current&issnonline=2632-8682 #Chemsky
How short can you make a PROTAC linker? We designed the first degrader of an ER-resident protein (IRE1a) that has physicochemistry more like a molecular glue than a traditional PROTAC pubs.rsc.org/en/content/a... #PROTAC #TPD @rscmedchem.rsc.org
Structure-guided design of a truncated heterobivalent chemical probe degrader of IRE1α
IRE1α is an ER protein involved in the unfolded protein response (UPR) and dysregulation of the ER stress pathway has been implicated in several diseases. Inhibitors of the cytoplasmic endonuclease or...
pubs.rsc.org