"The field has completely turned on its head, and now we know inflammation is a huge part of the pathogenesis of Alzheimer's." Prof @tspiresjones.bsky.social (UK DRI at Edinburgh) discusses the complex role of inflammation in Alzheimer's, on BBC's Inside Health ⬇️ www.bbc.co.uk/sounds/play/...

Inside Health - Is inflammation behind all chronic disease? - BBC Sounds

How understanding inflammation could transform treatments from cancer to Alzheimer’s.

bbc.co.uk

How can the brain 🧠 promote healthy ageing? @ulelab.bsky.social at King's and Dr Mathieu Bourdenx (UCL) have been awarded £3.8m by @wellcometrust.bsky.social to study role of interstasis in protecting neurons. www.kcl.ac.uk/news/3.8m-aw... #AgingResearch @ukdri.ac.uk @uclbrainscience.bsky.social

£3.8m awarded to study protective mechanisms against neuron damage and ageing | King's College London

A new study, co-led by neuroscientists at King’s College London, University College London and the UK Dementia Research Institute (UK DRI), will investigate how neurons can protect themselves from toxic protein accumulation, with implications for neurodegenerative diseases and ageing.

kcl.ac.uk

Glad to see this work finally out! A joy working with the incredible Nurun Fancy to figure out the interaction between TREM2 and CD33, how TREM2 variants differ and what happens to other cell types in cases with TREM2 variants. Thanks to everyone involved in the study, it was a great team effort!

UK Dementia Research Institute@ukdri.ac.uk · 2w ago

Could a protective gene counteract risk of Alzheimer's in people with a high-risk gene variant? 🧬 Researchers led by Dr @jojacksonhere.bsky.social revealed how TREM2 – a well-known Alzheimer’s risk gene – interacts with CD33, a gene that can reduce disease risk. ukdri.ac.uk/news-and-eve...

How might neurons protect themselves from toxic protein build-up?🧠 @ulelab.bsky.social & @mbourdenx.bsky.social have been awarded £3.8m by @wellcometrust.bsky.social to study role of interstasis in protecting neurons ukdri.ac.uk/news-and-eve... @kingsioppn.bsky.social @uclbrainscience.bsky.social

Two UK DRI Group Leaders awarded major Wellcome funding to study protective mechanisms against neuron damage and ageing

A new study, co-led by researchers at the UK DRI at King’s and the UK DRI at UCL will investigate how neurons can protect themselves from toxic protein accumulation, with implications for neurodegener...

ukdri.ac.uk

Could a protective gene counteract risk of Alzheimer's in people with a high-risk gene variant? 🧬 Researchers led by Dr @jojacksonhere.bsky.social revealed how TREM2 – a well-known Alzheimer’s risk gene – interacts with CD33, a gene that can reduce disease risk. ukdri.ac.uk/news-and-eve...

What can scientists learn from the brains of centenarians? 🧠 @sj-marzi.bsky.social, Dr Alexi Nott & Prof Henne Holstege investigate what makes some people resilient to dementia into old age, in a major new project 👏 ukdri.ac.uk/news-and-eve... @alzheimersresearchuk.org

UK DRI researchers awarded Dementia Frontiers Fund project to study centenarian brains

An international team led by Dr Sarah Marzi (UK DRI at King’s), with Dr Alexi Nott (UK DRI at Imperial) and Professor Henne Holstege (Amsterdam UMC and VIB-KU Leuven Center for Neuroscience) has won £...

ukdri.ac.uk

What can scientists learn from the 🧠 brains of centenarians 💯? @sj-marzi.bsky.social co-leads team EMERALD — asking what protects some people's brains from #dementia. www.kcl.ac.uk/news/what-ca... @ukdri.ac.uk @imperialcollegeldn.bsky.social @amsterdamumc.bsky.social @alzresearchuk.bsky.social

What can scientists learn from the brains of centenarians? £1.5m awarded from the Dementia Frontiers Fund | King's College London

Dr Sarah Marzi will co-lead team EMERALD, who have been awarded £1.5m from the Dementia Frontiers Fund to study how some people's brains may be more resiliant to dementia, with the aim to leverage these insights to develop therapeutics.

kcl.ac.uk

Join us on 21 July at 2pm to learn about the Race Against Dementia x @ukdri.ac.uk AI Innovation Fellowship Scheme, hear from speakers and get tips on applying. #AI youtube.com/live/1XpA9Sk...

Applying for the RAD X UK DRI AI Innovation Fellowship

YouTube video by Dementia Researcher

youtube.com

We're excited to be taking part in the Health Data Research UK (HDR UK) Black Internship Programme for the second year 🎉 A warm welcome to the five students who will be spending time at our centres across the UK, learning new skills and developing their talents.

How does the cell's transport network go wrong in neurodegenerative conditions? 🧠 New research led by @avezovlab.bsky.social (UK DRI at @cneurodept.bsky.social ) reveals new insight and a potential therapeutic avenue 👉 ukdri.ac.uk/news-and-eve...

King's researchers identify a new mechanism for neuronal death in #dementia, called karyoptosis, that links the build-up of toxic proteins to neurons dying. @alzheimersresearchuk.org @ukdri.ac.uk @rcasterton.bsky.social

New mechanism found for neuronal death in Alzheimer's and frontotemporal dementia | King's College London

Markers of a new mechanism for cell death, called karyoptosis, have been found in brains of patients with Alzheimer’s disease and frontotemporal dementia (FTD).

kcl.ac.uk

Where there’s a common vision, there’s an opportunity for collaboration. The @ukdri.ac.uk shares our ambition to improve tests, treatments and ultimately find cures for people living with motor neuron disease and rare dementias. Learn more: https://t.ly/snVaa #PartnerForChange

Last month we celebrated the official launch of our Parkinson’s Research Centre, in partnership with @parkinsons.org.uk 🎉 📹 Watch the video below to hear Centre Director Prof Miratul Muqit outline his vision for the new centre. ukdri.ac.uk/news-and-eve...

Around six million people live with Down syndrome globally, and around 90% will develop Alzheimer’s in midlife. Dr Frances Wiseman & colleagues have developed two new models of Down syndrome related Alzheimer’s, that could enable better study of the condition's impact 👉 ukdri.ac.uk/news-and-eve...

Our researchers at the UK DRI at Edinburgh are featured on the BBC today, highlighting how AI is transforming the search for treatments for neurodegenerative conditions 👏 Thank you to Steve, who generously shared his story and why research gives him hope 💙 www.bbc.co.uk/news/article...

AI used to speed up search for motor neurone disease drugs

Researchers hope the work will help identify affordable, effective drugs to treat conditions like MND.

bbc.co.uk

This #DementiaActionWeek, we were delighted to welcome @vikkislademp.bsky.social & @alisonebennett.bsky.social to UK DRI at King’s Researchers showcased how they're uncovering new opportunities to diagnose early & slow onset by studying underlying processes & harnessing data science advances.

In #DementiaActionWeek learn how our universities are working with @ukdri.ac.uk to spearhead efforts to diagnose and treat this devastating disease. This includes better testing to enable accessible, accurate and early detection, even before symptoms appear. www.russellgroup.ac.uk/impact/diagn...

Diagnosing dementia: developing blood tests at the UK Dementia Research Institute | Russell Group

Dementia presents a major health challenge in our ageing society. Its personal, societal and economic consequences are devastating. With disease-modifying therapies finally on the horizon, there is re...

russellgroup.ac.uk

🧪I'm deeply honoured to be elected a member of @acmedsci.bsky.social. Very grateful to my wonderful trainees, mentors, collaborators, and colleagues over 22 yrs from @edinunineuro.bsky.social @ukdri.ac.uk @cmvm-edinburghuni.bsky.social @unityhealthto.bsky.social @utoronto.ca @theneuro.bsky.social

Academy of Medical Sciences@acmedsci.bsky.social · 3mo ago

Congratulations to the 60 exceptional biomedical and health scientists elected to the Academy Fellowship today in recognition of their outstanding contributions to advancing medical science! 🎉 Meet our new Fellows: bit.ly/3Rb82JT

Only 2% of people with dementia symptoms ever get a specialist diagnostic test We are developing: 🩸 Blood tests to distinguish between conditions ⌚ Smartwatch AI detecting Parkinson's 7 years early 🛏️ Sleep mats predicting tau accumulation www.russellgroup.ac.uk/impact/diagn... #DementiaActionWeek

Diagnosing dementia: developing blood tests at the UK Dementia Research Institute | Russell Group

Dementia presents a major health challenge in our ageing society. Its personal, societal and economic consequences are devastating. With disease-modifying therapies finally on the horizon, there is re...

russellgroup.ac.uk

@sj-marzi.bsky.social has been awarded $1.4m from @asapresearch.parkinsonsroadmap.org as part of a $9m international collaboration investigating how environmental toxicants may influence Parkinson’s disease. www.kcl.ac.uk/news/9m-awar... @ukdri.ac.uk #ParkinsonsResearch

$9m awarded to uncover how environmental toxicants influence Parkinson's | King's College London

Dr Sarah Marzi receives $1.4m from a Collaborative Research Network grant awarded by Aligning Science Across Parkinson's (ASAP) to study link between toxicants and Parkinson’s disease.

kcl.ac.uk

The best reasons to apply to the SPARK NS program don’t come from SPARK NS. Hear below a message from Miratul Muqit, PhD, Professor of Experimental Neurology, University of Dundee, and Director of UK Dementia Research Institute Parkinson’s Research Centre, University of Edinburgh. @ukdri.ac.uk

From the organising committee, from @edinunineuro.bsky.social, from the @ukdri.ac.uk, the one and only Dr Philip Hasel @philiphasel.bsky.social Registration is closes May 18th: www.physoc.org/events/uk-gl... #neuroscience #careers #networking #UK #science #neuroskyence #glia #Bristol #June

We are exceptionally proud to announce that the second UK Glia Network meeting will be closed by FRS, Prof Bal Khakh Returning to the UK to join the @ukdri.ac.uk we are super pleased he is coming to Bristol in June You can come too, registration still open: www.physoc.org/events/uk-gl...

Coming from Edinburgh @edinunineuro.bsky.social and the @ukdri.ac.uk, the ineffable @bdiazcastro.bsky.social #neuroscience #networking #science #career #opportunities #UK #glia Registration closes May 18th: www.physoc.org/events/uk-gl...

Professor Corinne Houart and Dr Richard Taylor (@ukdri.ac.uk at King's) received a new £500k+ grant from @alzresearchuk.bsky.social to study how RNA-binding proteins, which are disrupted in #dementia, might be important for protecting against degeneration. @cohouart.bsky.social

Join us! Research Fellow role at UCL @ukdri.ac.uk @uclqsion.bsky.social with me & @sj-marzi.bsky.social studying oligodendrocytes, genetics & epigenetics in ageing & neurodegeneration using multiomics/bioinformatics. Collaboration with Alexi Nott & @rikeshrajani.bsky.social Closing date: 2nd June

Dementia Researcher@dementiaresearcher.bsky.social · 3mo ago

Research Fellow role at UCL @ukdri.ac.uk with @dervissalih1.bsky.social studying oligodendrocytes, genetics and epigenetics in ageing and neurodegeneration using multiomics and bioinformatics. Closing date: 2nd June www.dementiaresearcher.nihr.ac.uk/job/research...

💡New evidence about the causes of a common type of stroke offers clues as to why widely used treatments like aspirin may not work. The new study, led by Prof Joanna Wardlaw found that instead of fat build-up, enlargement & widening of arteries may cause lacunar stroke 👉 lnkd.in/e-__v2kK

Could we boost the nervous system's ability to repair damaged brain cells?🔬 New research by Dr Jobert Vargas and Prof Giampetro Schiavo (UK DRI at UCL) in collaboration with Dr Andrea Serio (UK DRI at King’s), uncovers key insight into how human neurons can be repaired. ukdri.ac.uk/news-and-eve...

Could improving the way we collect & store brain tissue help better preserve it for research? A study by Dr @jojacksonhere.bsky.social & Prof Paul Matthews (UK DRI at Imperial) with researchers at McGill University reveals temperature plays a greater role than previously thought👉 lnkd.in/eG6yqJzD

Join the UK DRI's Prof Julie Williams, & neuroscientist & psychologist Dr Sabina Brennan as they share insights from the forefront of dementia research and care. 📍 Cheltenham Science Festival 🗓️ 7 June, 3:15pm www.cheltenhamfestivals.org/events/repai...