🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: The competition between splicing and 3′ processing shapes the human transcriptome By Soles et al. and Yongsheng Shi ➡️ https://ow.ly/bXG150ZachI UC Irvine UC Irvine School of Medicine #RNAprocessing #splicing #mRNA #transcription

Looking forward to sharing this story in person at #RNASociety on Friday! I'm giving a talk at the RNA and Disease session and Liza will have a poster (ID 528) on Friday evening.

Cassandra Hayne@cassandrahayne.bsky.social · 2mo ago

🚨The lab's first research paper is In Press at JBC! Congrats Liza and Magda!! Pontocerebellar Hypoplasia linked mutations of the deadenylase Target of EGR1 (TOE1) impair thermal stability, ribonuclease activity, and oligomerization - Journal of Biological Chemistry www.jbc.org/article/S002...

Excited to be part of this collaborative work on telomere biology in pluripotent cells. We found that nonsense-mediated mRNA decay (NMD) becomes essential for cell survival in the absence of TRF2, by preventing production of a dominant-negative TRF1 isoform. www.nature.com/articles/s41...

Nonsense-mediated mRNA decay safeguards telomeres in pluripotent stem cells - Nature Cell Biology

Markiewicz-Potoczny et al. report that the nonsense-mediated mRNA decay pathway protects telomeres in the absence of core Shelterin component TRF2 by regulating the stability and abundance of TRF1 at ...

nature.com

Uncovering the isoform-resolution kinetic landscape of nonsense-mediated mRNA decay with EZbakR https://www.biorxiv.org/content/10.1101/2025.03.12.642874v1

Excited to share our latest work! We asked if and how TDP-43 regulates RNA transport in neurons and if this is misregulated in ALS. We found that it works to keep RNAs *out* of neurites, and that loss of TDP-43 activity results in specific RNAs aberrantly accumulating there.