Excited to see this preprint out! New work on the development of the enigmatic unipolar brush cells from the lab of @lenakutscher.bsky.social

Lena Kutscher@lenakutscher.bsky.social · 5d ago

New preprint from the lab! Led by PhD students @vuslatakcay.bsky.social, Lisa Spänig and Wouter-Michiel Vierdag (EMBL), we investigated the development and differentiation of cerebellar unipolar brush cell progenitors (UBCPs). www.biorxiv.org/content/10.6...

Congratulations to all the F2F fellows! Wishing you all the very best on the exciting journey ahead.

Simons Foundation@simonsfoundation.org · 5d ago

We're pleased to announce the 2026 class of our Fellows-to-Faculty program! This fellowship supports talented early-career scientists and their research visions as they transition into tenure-track faculty positions in autism and #neuroscience research. See the new class: https://bit.ly/4yXUjrd

Co-option of certain transposable elements as regulatory elements in specific cerebellar cell states, e.g. HERVL in rhombic lip–derived neuroblasts. Led by awesome Tetsuya @tyamadat.bsky.social, together with @ioansarr.bsky.social and @kaessmannlab.bsky.social

Tetsuya Yamada@tyamadat.bsky.social · 7d ago

Our manuscript on the co-option of TEs as cerebellar CREs is now officially published in @natcomms.nature.com! Huge thanks to @kaessmannlab.bsky.social @marisepp.bsky.social, and @ioansarr.bsky.social for the fantastic collaboration throughout this project! www.nature.com/articles/s41...

New preprint 📢 Thrilled to share our long-awaited work on the role of RSX in marsupial X-inactivation. This was a huge team effort over the years, led by @aureliencourtois.bsky.social @sermenchero.bsky.social Sugako Ogushi and Waz Varsally, that allowed us to set up genome editing in opossum embryos

Genome editing of marsupial RSX reveals conserved and divergent principles in mammalian X-inactivation

X-chromosome inactivation balances X-gene dosage between the sexes in eutherians and marsupials. The lncRNA Xist mediates X-inactivation in eutherians but is absent from marsupials. An evolutionarily ...

biorxiv.org

Better late than never... an update on the recent work from the lab. First of all, the Foundation: @astridd93.bsky.social phenomenal paper on the evolution of layering in the cerebral cortex 🧵1/7 www.biorxiv.org/content/10.1...

Might cerebellar disinhibition underlie Restless Legs Syndrome symptoms? Will Joo found that loss of the RLS-associated gene meis1b perturbs locomotion in zebrafish by disinhibiting cerebellar output. www.sciencedirect.com/science/arti...

According to @edvardmoser.bsky.social, director of the Kavli Institute for Systems Neuroscience, the four recipients of the Kavli Prize in Neuroscience challenged what had long been regarded as a central dogma in neuroscience. By Alissa de Chassey www.thetransmitter.org/awards/four-...

Protein synthesis pioneers garner Kavli neuroscience prize

Their research revealed how neurons synthesize proteins in previously unrecognized places.

thetransmitter.org

🧬 Join us at the 25th International Gene Forum – with stellar speakers from around the world (again)! Register now to secure your spot! 📅 August 25–26, 2026 📍 Estonian National Museum, Tartu, Estonia 🌐 Information & registration: www.geneforum.ee #Geneforum2026 #Geneforum

“By comparing gene activity across many species - from early vertebrates to humans - we can understand how we became who we are.” (hopefully precise enough) Prof. Dr. Henrik Kaessmann, evolutionary geneticist Recipient of the Ernst Schering Prize 2026 ❤️ Thrilled to see this, Henrik - congrats!

Kaessmann Lab@kaessmannlab.bsky.social · 2mo ago

Thrilled and honored to receive the Ernst Schering Prize 2026!🎉 Also deeply grateful to have been elected to the German Academy of Sciences. Both are recognitions of our whole group – I’m immensely thankful to all team members, past and present!❤️ tinyurl.com/hjrejv3p tinyurl.com/muw7j6mr

For all cerebellum and cerebellar nuclei aficionados: A cre line specifically tagging the large, excitatory B-cells in the mouse cerebellar nuclei: www.biorxiv.org/content/10.6... Lmk if you want to use it!

"Genetic analysis of circulating metabolic traits in 619,372 individuals" www.nature.com/articles/s41... Congrats to the teams of Priit Palta and @kauralasoo.bsky.social

Genetic analysis of circulating metabolic traits in 619,372 individuals - Nature

A genome-wide association study combining data from the Estonian Biobank and the UK Biobank identifies many common and low-frequency locus–metabolic trait associations, enabling the identification of ...

nature.com

Kaur Alasoo@kauralasoo.bsky.social · 2y ago

Happy to share our most recent GWAS meta-analysis of 249 circulating metabolic biomarkers (Nightingale Health platform) in up to 619,372 individuals. www.medrxiv.org/content/10.1...

New from the lab: BARseq3! Barcodes + high efficiency spatial transcriptomics and translatomics in the same cells, or just a nice spatial transcriptomics assay. All in a modular, expandable system to enable truly multimodal measurements. Check it out: www.biorxiv.org/content/10.6...

Huge congrats from our whole lab to Sir David Attenborough on his 100th birthday!!! 🎉🥳❤️ I had the honor of meeting him - and being interviewed by him - in 2013 for his BBC documentary "Rise of Animals: Triumph of the Vertebrates", which featured part of our work.

What should Europe do when demand for #ERC funding keeps rising? Restrict access or invest in excellence? Please read our open letter calling for reconsideration of the ERC 2027 resubmission restrictions & for constructive alternatives that preserve openness Consider to share & sign - see below 🧪

#erc | Johanna Joyce

What should Europe do when demand for its most successful frontier research programme keeps rising? Restrict access, or invest in the excellence it has created? A new open letter, spearheaded by Sara...

linkedin.com

🦈🧠2 JOB OFFERS in the brand-new Neuroshark group starting at the Institute of Neuroscience Paris-Saclay (NeuroPSI)? Lab manager: www.linkedin.com/posts/idoia-... Bioinformatician: www.linkedin.com/posts/idoia-... Curious about the lab but not your profile? Feel free to contact me

Lab manager job | Idoia Quintana Urzainqui

JOB OPPORTUNITY 🦈 🧠 🔬. We are looking for a Lab Manager to help establish a new group studying shark embryos to understand the origin of the vertebrate brain. Reach out if this motivates you. We’re ba...

linkedin.com

By applying for an MSCA Postdoctoral Fellowship with the University of Tartu, you can access 3 funding pathways: MSCA, ERA Fellowships, and national funding schemes. Get in touch if interested in brain development, autism spectrum disorders, and single-cell genomics. ut.ee/en/content/p...

Postdoctoral research at the University of Tartu

Estonia, a hub of innovation and cutting-edge research, offers a vibrant ecosystem for postdoctoral researchers.

ut.ee

Thrilled to present our comparative study on the evolution of zygotic genome activation (ZGA)!! 🥚🧬 Amazing PhD work of @campobes.bsky.social together with @fedemantica.bsky.social and many collaborators! @melisupf.bsky.social @crg.eu. Thread below 1/15 www.biorxiv.org/content/10.6...

Very proud of this and so cool that enhancer-level models can predict the effect of genetic variation. There is so much personal variation in terms of gene regulation in the human brain, it is fantastic to uncover this thanks to technology (whole-genome sequencing and single-cell multiomics) and AI

Alexandra P@alexanrna.bsky.social · 4mo ago

1/ 🧬 Happy to share our new preprint on modeling cis-regulatory variation in human brain enhancers across a large Parkinson’s disease cohort: www.biorxiv.org/content/10.6... Details in the thread below:

Exciting study by @lenakutscher.bsky.social and @doctorpauln77.bsky.social on male bias in medulloblastoma: “testosterone and the XY genotype cooperate to increase the abundance of specific cerebellar progenitor populations” Elegant use of Four Core Genotypes mice + recapitulation in organoids

Lena Kutscher@lenakutscher.bsky.social · 4mo ago

New preprint alert! I'm excited to share our latest preprint where we investigate the underlying developmental causes of the male bias in the pediatric brain tumor Group 3/4 medulloblastoma. www.biorxiv.org/content/10.6...

Amazing Margarida and her amazing research. Curiosity and enthusiasm in action 💙

The Francis Crick Institute@crick.ac.uk · 4mo ago

Crick evolutionary biologist @margaridamcm.bsky.social is working with conservation charity ZSL to investigate an enduring mystery: how the placenta has evolved with incredible variation across species. Read the full story: www.crick.ac.uk/news/2026-03...

Also out today - A quick intro piece on the role of the cerebellum in cognition. What does it do? How will we find out? This is what @actlab.bsky.social and I think the critical questions are right now. It was fun to write - especially the section on evolution.... journals.plos.org/plosbiology/...

How does the cerebellum contribute to cognitive functions?

The role of the cerebellum in motor functions is well understood. But why is the same circuitry engaged in functions such as working memory, language, and social cognition? This Unsolved Mystery looks...

journals.plos.org

interested in working on sex differences during development and in tumor initiation! come join our lab via the MSCA MasterClass

Deutsches Krebsforschungszentrum (DKFZ)@dkfz.bsky.social · 5mo ago

Do you want to do your #postdoc in #cancerresearch with the most prestigious fellowship in Europe? Apply to DKFZ #MSCA MasterClasses by May 18. 26 Projects in cancer research including #cellandmolecularbiology #genomics #bioinformatics #immunology. @horizoneu.bsky.social 👉Apply here: t1p.de/nx6tu

Inhibitory neurons are among the most transcriptomically diverse class of neurons in the CNS, with some brain regions having 60+ distinct cell types. Do humans share the same repertoire as rodents? Birds? Fish? 1/13

Warm congratulations to The Brain Prize winners 2026, Professor David Ginty and Professor Patrik Ernfors, for their pioneering work on how the nervous system detects and processes touch and pain. Karolinska Institutet HHMI #Neuroscience #BrainPrize2026

A beautiful 😍 review on vertebrate organ evolution - from molecular basis and evolutionary forces to the emergence of novel forms and functions.

Margarida Cardoso Moreira@margaridamcm.bsky.social · 5mo ago

Our internal organs are evolutionary marvels. New technologies are transforming our understanding of the evolution of vertebrate organs. You can find more by reading here: rdcu.be/e5EgU #EvoBio #EvoDevo 🐟🦎🐢🦇🐊🦜

How have concerted and mosaic evolutionary mechanisms shaped the expansion of the human cerebellum? Our review with @tyamadat.bsky.social and @ioansarr.bsky.social available free till March 29: authors.elsevier.com/a/1ma2wFzn7a...

Mari Sepp@marisepp.bsky.social · 6mo ago

This paper marks the end of a long but rewarding project - and the start of something new (more below👇). Massive thanks to @kaessmannlab.bsky.social, @ioansarr.bsky.social, @tyamadat.bsky.social, our amazing collaborators @steinaerts.bsky.social, Stefan Pfister, Rüdiger Behr and the entire team! 💙

Ramsey Najm and I have a joint postdoc position advertised through the @hlsalliance.bsky.social Interinstitutional Postdoc call! Our project proposes to generate better posterior cerebellar organoids to improve fidelity of pediatric medulloblastoma models. www.health-life-sciences.de/opportunitie...

Hiring a PhD student! 🎓 Looking for a PhD student to work on the prediction of complex diseases by integrating genetics, multi-omics, and electronic health records. Details: genomics.ut.ee/sites/defaul... Please share with anyone interested!

Some friends and I wrote a review with @biologists.bsky.social !! Together with Esther Becker and Simone Mayer, we explore the state of the cerebellum organoid field and offer practical guidance on getting this model system started in your own lab. journals.biologists.com/dmm/article/...

Generating cerebellar organoids from pluripotent stem cells

Summary: This Special Article provides a comprehensive overview of the methods, applications and considerations for the generation of cerebellar organoids.

journals.biologists.com

Congrats to @urmovosa.bsky.social and the international research team behind this achievement, including colleagues at @estbiobank.bsky.social!

Urmo Võsa@urmovosa.bsky.social · 6mo ago

Preprint with the results of genome-wide eQTL analyses across 43,301 blood samples from the eQTLGen Consortium is now online! A major collaborative effort- many thanks to everyone involved, especially @robertwarmerdam.bsky.social, @ludefranke.bsky.social, and all eQTLGen collaborators!👇