Maria Antonietta Tosches
@matosches.bsky.social
Associate Professor @ Columbia University. Brain evolution, plasticity and regeneration. www.tosches-lab.com
🧠🧬🦤 Excited to be at #ICN2026! We're recruiting a #postdoc to study the neural and molecular basis of migration. Projects could include field experiments, captive studies, and spatial/single-cell. Stop by poster 72 today or email! @zuckermanbrain.bsky.social #neuroethology delmorelab.com/recruitment
Excited to share a new preprint from the lab, by @andrewmatheson.bsky.social and team, where we dive into the superpower of newts: plasticity! www.biorxiv.org/content/10.6... Like many good projects, this started with a serendipitous observation... 🧵1/5
Congratulations to lab members @andrewmatheson.bsky.social , Tori Saltz and recent alumna @ecbjaeger.bsky.social on their #ICN2026 awards! Keep an eye on these rising stars and don't miss Andrew's and Tori's talks at @neuroethology.org this week
Prebilaterian Origin of Monoaminergic Signalling is out! This paper represents four years of work, not only mine, but friends and colleagues. I am particularly grateful to Tatiana Mayorova; without her help, this paper would not have been nearly as complete. www.sciencedirect.com/science/arti...
Prebilaterian origin of monoaminergic signaling
Monoamines such as serotonin, dopamine, and tyramine regulate physiological and behavioral processes in bilaterian animals, but the evolutionary origi…
sciencedirect.com
I am excited to announce the latest paper from our lab, published in Science ! In this study, we show that thalamocortical-like circuits in the zebrafish brain process sensory information hierarchically across topographically organized forebrain circuits.
Hierarchical sensory processing in zebrafish thalamocortical-like circuits
Thalamocortical projections shape the functional regionalization and parallel sensory computations across the mammalian cortex. However, the principles of thalamocortical computations in non-mammalian...
science.org
Kavli Institute for Systems Neuroscience@kavlintnu.bsky.social · last mo.Out now in @science.org by @emreyaksi.bsky.social, Anh-Tuan Trinh and colleagues at the Kavli Institute in Trondheim: Hierarchical sensory processing in zebrafish thalamocortical-like circuits doi.org/10.1126/scie...
It is a huge honor to become an EMBO Associate Member. I am grateful to my mentors and to all the brilliant trainees in my lab.
EMBO@embo.org · last mo.Welcome and congratulations to the 60 new members and 11 associate members who have been elected to the EMBO Membership! They join a community of more than 2,200 leading scientists. 🧪 https://www.embo.org/press-releases/seventy-one-leading-scientists-elected-to-the-embo-membership/ #EMBOMembers2026
Better late than never... an update on the recent work from the lab. First of all, the Foundation: @astridd93.bsky.social phenomenal paper on the evolution of layering in the cerebral cortex 🧵1/7 www.biorxiv.org/content/10.1...
I disagree. Is head is full of tadpoley thoughts, unknown and unimaginable.
Colton the fish squeezer🐟🪴📚🏕️🐝@fishsqueezer.bsky.social · last mo.Hiding from me under two strings of algae, not a single thought in his rotund little head. 🐍
Looking forward to presenting our latest work in Seattle!
allen institute@alleninstitute.org · 4mo agoApplications are open for the Lake Conference on Comparative and Evolutionary Neurobiology - co-hosted with Circuit Neuroscience Basel! 🗓️ Oct. 25-29, 2026 📍 Seattle, WA 🧠 All career stages welcomed. 🔗 https://alleninstitute.org/events/lake-conference-comparative-and-evolutionary-neurobiology-2026/
Chuffed to see our paper with @geneyeo.bsky.social finally published in @nature.com. www.nature.com/articles/s41... Very grateful to Fede, Susie, and Dave from my lab, and Sammi, Eric, and Pratibha from Gene's lab. What did we find? ⬇️ ⬇️ ⬇️
Single-cell and isoform-specific translational profiling of the mouse brain - Nature
Post-transcriptional regulation of mRNA translation was explored using Ribo-STAMP and single-cell RNA sequencing to reveal cell-type-specific and isoform-specific translation patterns across hipp...
nature.com
very sad news. Peer Bork was one of the leaders of our field, a wonderful scientist, and he's much too young to be gone. www.embl.org/news/embl-an...
In remembrance of Peer Bork | EMBL
EMBL and its community are deeply saddened by the death of Peer Bork, the organisation’s Interim Director General.
embl.org
Thank you @fredcauseret.bsky.social for this nice highlight of our work and @idoiaeu.bsky.social 's!
Frédéric Causeret@fredcauseret.bsky.social · 7mo agoWe're happy to highlight two very exciting preprints from @idoiaeu.bsky.social and @matosches.bsky.social about the evolution of Cajal-Retzius cells. Find our perspective in @dev-journal.bsky.social here: doi.org/10.1242/dev....
Excited to present our recent work at #SfN25 's Evolutionary Neurogenomics session this Tuesday!
allen institute@alleninstitute.org · 9mo ago🧬 Evolution meets neuroscience at #SfN25! Learn how multi-omics approaches are revealing how evolution acts on cell types, underpinning neural circuitry and behavior changes across diverse species. 📅 Tues., 11/18, 9:30am–12:00pm 📍 Rm 6CF 📲 https://www.abstractsonline.com/pp8/#!/21171/session/1213
New faculty job opening at @zuckermanbrain.bsky.social @columbiauniversity.bsky.social Come be our colleague! Application deadline: November 22 apply.interfolio.com/176153
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Looking forward to speaking at the next TIBBE seminar!
The Integrative Biology of Brain Evolution (TIBBE)- Network@tibbe-evolneuro.bsky.social · 11mo ago🤩 Join us for the next TIBBE seminar: Evolution of brain cell types. September 10, 2–3pm UTC This event brings together 2 outstanding evolutionary and developmental neuroscientists who will present their work, followed by an interactive discussion with the audience: www.crowdcast.io/c/evolution-...
Scientists have mapped the entire connectome of a 3-day-old marine worm larva (Platynereis dumerilii), including over 9,000 cells and 200+ neuronal types. This resource can help us understand how nervous systems evolved and coordinate whole-body movement. buff.ly/IPxFCHs
Excited to share our latest work on brain evolution, where we dive into the evolution of Cajal-Retzius cells! If you are interested in cell type evolution and cerebral cortex evo-devo, please read on… www.biorxiv.org/content/10.1... 🧵 1/7
Evolution of Cajal-Retzius Cells in Vertebrates from an Ancient Class of Tp73+ Neurons
In the developing cerebral cortex, Cajal Retzius (CR) cells are early-born neurons that orchestrate the development of mammalian-specific cortical features. However, this cell type has not been conclu...
biorxiv.org
We’re looking for curious, innovative science leaders at EMBL Heidelberg! 🔬🧬🦠 Join a vibrant, interdisciplinary community where collaboration and innovation are nurtured at all levels. Take a look at these four open positions 👇
Evolution’s eye game is wild, but mollusks take it to another level CRISPR in apple snails gives us a new model to dissect how nature rebuilds complex organs like the camera-type eyes we humans possess It turns out Evolution doesn’t just innovate, it rewinds, remixes, & regenerates rdcu.be/ezw0t
A genetically tractable non-vertebrate system to study complete camera-type eye regeneration
Nature Communications - Accorsi et al. show that the apple snail Pomacea canaliculata has eyes similar to humans and can fully regenerate them. They then developed genetic tools to establish these...
url.us.m.mimecastprotect.com
Happy to share our publication - Comparative connectomics of two distantly related nematode species reveals patterns of nervous system evolution www.science.org/doi/10.1126/...
Comparative connectomics of two distantly related nematode species reveals patterns of nervous system evolution
Understanding the evolution of the bilaterian brain requires a detailed exploration of the precise nature of cellular and subcellular differences between related species. We undertook an electron micr...
science.org
Today, the @fwf-at.bsky.social honors Elly Tanaka, IMBA's Scientific Director, with the Wittgenstein Award – the premier research award of Austria - for her groundbreaking discoveries in the field of regenerative biology. Congratulations, Elly! More on the award: imba.science/43Y93sC
Österreichischer Wissenschaftsfonds FWF@fwf-at.bsky.social · last yr.Die Biochemikerin Elly Tanaka ist Österreichs #Wittgenstein-Preisträgerin 2025. 🏆 Elly Tanaka vom Vienna BioCenter @oeaw.bsky.social ist international führende Expertin auf dem Gebiet der Regeneration komplexer Körperstrukturen. Wir gratulieren! 🎉 www.fwf.ac.at/aktuelles/de...
How do brain circuits evolve? We started looking for some answers by using synapse-resolution cross-species comparative connectomics on an entire olfactory circuit 👇 bit.ly/44aVm9E
Get the word out far and wide. New opportunity from the Simons Foundation in the Eco-Evo space. 2026 Simons Graduate Fellowship in Ecology and Evolution Awards, due July 31, 2025, only for incoming PhD students who plan to start their PhDs in Fall 2026. www.simonsfoundation.org/grant/simons...
Simons Graduate Fellowships in Ecology and Evolution
The purpose of these awards is to provide support for students entering U.S.-based Ph.D. programs with a plan to perform research in ecology and evolution. While we will consider all projects in ecolo...
simonsfoundation.org
The axolotl has the ability to regenerate its brain. Using single-cell transcriptomics, four Science studies in 2022 revealed evolutionary innovations in reptile and amphibian brains. Learn more during #AmphibianWeek: scim.ag/3EEKMxZ
Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...
A human-specific enhancer fine-tunes radial glia potency and corticogenesis - Nature
HARE5, a human accelerated region enhancer, modulates cortical development by influencing neural progenitor cell behaviour, leading to an enlarged neocortex with increased functional independence betw...
nature.com
Check out our latest issue to read a Q&A with @thibautbrunet.bsky.social, who studies the evolutionary origin of animal morphogenesis at the Institut Pasteur. www.cell.com/current-biol...
Thibaut Brunet
Interview with Thibaut Brunet, who studies the evolutionary origin of animal morphogenesis at the Institut Pasteur.
cell.com
Wonderful work by @nataliabaumann.bsky.social & the @djabaudon.bsky.social team showing how progenitor metabolism regulates region-specific neurogenesis! Glad our group could contribute, thanks to Eleonora Conti & Roberto Sansevrino. www.cell.com/cell/fulltex...
Regional differences in progenitor metabolism shape brain growth during development
Brain-wide birthdate mapping reveals that while hindbrain neurogenesis is transient, forebrain neurogenesis is temporally sustained through spatiotemporal regulation of progenitor mitochondrial functi...
cell.com
New preprint from my PhD in @amphispacelab.bsky.social is out! 🥳 We investigated the evolution of my favorite gene FoxQ2 across 21 animal phyla, and found three ancient paralogs with a very dynamic history. More on phylogeny, synteny, and comparative in situs in the 🧵 below! tinyurl.com/2j96px45
Evolutionary dynamics of FoxQ2 transcription factors across metazoans: A tale of three ancient paralogs
FoxQ2 is a highly conserved class of Forkhead-box transcription factors expressed on the anterior side of the body in cnidarians and bilaterians. Despite this conserved expression pattern, recent phyl...
tinyurl.com
