One of my hardest and longest PhD challenges is coming to a close (well, almost). Very happy to finally share the preprint to our updated Gsens method! Major updates include the extension to multiple exposure scenarios, along with using raw data, estimating mediation effects and many more.

medRxivpreprint@medrxivpreprint.bsky.social · 3w ago

Genetic sensitivity analysis: estimating genetic confounding and environmentally mediated genetic effects using multiple exposures https://www.medrxiv.org/content/10.64898/2026.07.16.26358236v1

One week left to apply!

Torsten Günther@trstngnthr.bsky.social · 2mo ago

I am recruiting a PhD student (fully funded, 4yrs) to analyze modern 🧬 and ancient 🦴 genomic data from humans and domestic animals 🐑 Please share, I am happy to chat at #ICP2026 or #SMBE2026 this summer www.uu.se/en/about-uu/...

So excited to share my first preprint of grad school! Check out this thread to learn more about a cool new technique we are using to learn more about hidden layers of RNA regulation! Thank you so much to my coauthors, mentors, and lab for helping us get this story up!

Stirling Churchman@stirlingchurchman.bsky.social · last wk.

RNA-seq tells us how much RNA is present in the cell. But to understand gene regulation, we need to easily measure the synthesis and decay rates driving this abundance. We introduce AIR-seq: analog intrinsic recoding sequencing. (1/6) www.biorxiv.org/content/10.6...

>Science is not an efficiency problem< "This is because creativity is fundamentally not an efficiency problem; process is not just the means of producing output, but rather a labor vessel that holds the near-invisible work that is truly important." Paul Cantrell, hachyderm.io/@inthehands/...

The bottom line is that evolutionary theory sheds light on how empirically successful methods in statistical genetics operate. It further simplifies those models to achieve better interpretability and scalability by leaving only biologically relevant parts of the model. (n/n)

Wellcome also implementing changes to manage the increasing number of applications. For for CDA and Discovery awards: - moving to ‘always-open’ rolling deadlines - 12 months period (after the first review) before resubmission wellcome.org/insights/art...

Rethinking the future of research funding | News | Wellcome

Wellcome is making changes to how and when people can apply for our funding so we can more effectively manage demand, easing the strain on our services, applicants and institutions.

wellcome.org

My coauthor Jay Falk's postdoctoral fellowship was terminated by the Trump administration for documenting the hummingbird example in this paper.

Andy Lee, PhD@andylee.bsky.social · 4w ago

In our Viewpoint (onlinelibrary.wiley.com/doi/abs/10.1...) we synthesize the gametic definition (outlined by Janicke et al below) and other definitions of sex (e.g., multivariate definition). We contend that is NO consensus on “biological sex” (maybe a consensus isn’t actually necessary…)

In our Viewpoint (onlinelibrary.wiley.com/doi/abs/10.1...) we synthesize the gametic definition (outlined by Janicke et al below) and other definitions of sex (e.g., multivariate definition). We contend that is NO consensus on “biological sex” (maybe a consensus isn’t actually necessary…)

There is No Consensus on Biological Sex

At this critical moment when misinformation about sex is being applied to policy globally, scientific clarification on the definition of biological sex is valuable. Here, we evaluate the primary appr...

onlinelibrary.wiley.com

Tim Janicke@timjanicke.bsky.social · 4w ago

In a new #Viewpoint we argue that the binary definition of #BiologicalSex based on gamete size is a scientifically robust framework that is entirely compatible with the diversity of sexual phenotypes and human gender identities. onlinelibrary.wiley.com/doi/10.1111/...

🚨 Fabulous job alert 🚨 The Mental Health Goals Omics Psychosis team is looking for a Psychology Assistant to join our Wales recruitment team. We're a friendly and motivated bunch, and there will be plenty of opportunities for learning and development. cardiffuniweb.eploy.net/vacancies/48...

Psychology Assistant in Hadyn Ellis Building | Internal & External Website

View details and apply for this Psychology Assistant vacancy in Hadyn Ellis Building. Psychology Assistant Division of Psychological Medicine and Clinical Neurosciences School of Medicine Colle...

cardiffuniweb.eploy.net

dcdehaas.github.io/grg/2025/03/... "We still end up with a slightly slower graph traversal by doing this encoding, but the 50% RAM savings seems worth it as we can essentially analyze biobank-scale datasets on a cheap consumer laptop now, entirely within RAM." Reads totally differently in 2026 lol

"The compiler infrastructure that began in 2000 as a federally funded two-person research project at the University of Illinois now supports multi-billion dollar hardware, software, and services industries worldwide" dl.acm.org/doi/10.1145/...

Thought I'd give this place a go again. I'm Kim. I'm a psychiatrist who does research on genetics and proteomics. I also do a lot of recruitment of people with psychosis for research studies. My clinical work is in a psychiatric genetics clinic in Cardiff.

New UK government guidance about "Safeguarding UK human genomic data". Applies specifically to Genomics England, Our Future Health, UK Biobank and NIHR BioResource, with major implications for sharing data outside the UK. www.gov.uk/government/p...

Very interesting new preprint from @jengreitz.bsky.social lab arguing that rather than there being significant enhancer-promoter compatibility, promoters simply differ in their enhancer responsiveness. If promoters are responsive, they respond to all enhancers. www.biorxiv.org/content/10.6...

David Baulcombe started out speaking about "the days when you could hypothesise about things without being too burdened by data."

Genetics Society UK@gensocuk.bsky.social · last mo.

Great to hear David Baulcombe, Honorary Member of the Genetics Society, give his talk, "An RNA world". From RNA silencing to gene regulation, it was a fascinating look at discoveries that have transformed genetics and continue to shape research today.

Veronica van Heyningen: "Genetics is a tool to explore biology, but biological observations in many organisms help to decipher genetics"

Genetics Society UK@gensocuk.bsky.social · last mo.

Veronica van Heyningen, Honorary Member of the Genetics Society, delivered a fascinating talk titled “Journey through genetics to biology”, reflecting on a remarkable career spanning human genetics, developmental biology, and disease gene discovery!

At @edinuni-irr.bsky.social today and tomorrow for the @gensocuk.bsky.social Anniversary Day talks. genetics.org.uk/events/anniv...

JOB ALERT! We are recruiting at @ucl-c4ia.bsky.social - a lecturer (Grade 8) or associate professor (Grade 9) in primate or human evolutionary anatomy (research and teaching). Contact Susan Evans or myself for further details. www.jobs.ac.uk/job/DRZ412/l...

Lecturer / Associate Professor in Primate or Human Evolutionary Anatomy at UCL

Searching for an academic job? Explore this Lecturer / Associate Professor in Primate or Human Evolutionary Anatomy opening on jobs.ac.uk! Click to view more details and browse other academic jobs.

jobs.ac.uk

Excited to see @jonj-udd.bsky.social's fantastic work out @genetics-gsa.bsky.social. Selection in _heterozygotes_ is the primary force shaping allele frequencies of loss-of-function mutations in humans, even in genes only associated with purely recessive diseases. 🧪🧬 doi.org/10.1093/gene...

Allele Frequencies at Recessive Disease Genes are Mainly Determined by Pleiotropic Effects in Heterozygotes

Abstract. The classic theory of mutation-selection balance predicts the equilibrium frequency of genetic variation under negative selection. The model pred

doi.org

Very good preprint on the evolution of the canine genome through joint dog and wolf genealogies (by Jasmin Rees @mattiassherman.bsky.social @anders-bergstrom.bsky.social @leospeidel.bsky.social and colleagues) 🧪🧬🐶🐺 www.biorxiv.org/content/10.6...

Joint dog and wolf genealogies reveal the evolution of the canine genome

Dogs and their closest extant relative, the grey wolf, diverged around 30k years ago, but have since experienced complex histories of gene flow involving other canids, adaptive pressures due to close ...

biorxiv.org

1/9 🚨 BREAKING OUT OF STEALTH MODE 🚨 Multivariate GWAS in Genomic SEM now runs on a laptop! New preprint + package update: a closed-form analytic solution makes multivariate GWAS ~800× faster, cutting runtimes from hours on HPC clusters to minutes on a personal computer.

The Predator Emerges

ALT: The Predator Emerges

static.klipy.com

📣🧬 Postdoc Alert🧬📣 We are hiring a 2+ year NERC-funded postdoc at Edinburgh Uni investigating causes and consequences of sex differences in recombination in house sparrows in Norway. Informal enquiries welcome at Susan.Johnston@ed.ac.uk 🙂 Details here: elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

Phil Trans A theme issue on statistical workflows royalsocietypublishing.org/rsta/issue/3...

Volume 384 Issue 2321 | Philosophical Transactions of the Royal Society A | The Royal Society

Influential themed journal issues across the physical mathematical and engineering sciences.

royalsocietypublishing.org

"Parkinson’s Law states that work expands to fill the time available. In the era of AI, workers now have a tool that expands to fill whatever a large language model can be persuaded to generate, which is to say, without limit." nooneshappy.com/article/appe...

While its an exciting subfield, it’s also a field where there are a lot of open questions about what these models truely encode and where there added value over more targeted smaller models is worth it. See this writeup of a recent meeting of experts: open.substack.com/pub/blekhman...

Seven points on the current state of AI in genomics

A grounded take from the messy middle of an AI revolution

open.substack.com

Login access to HPC disabled (Copy Fail / Dirty Frag) UKB RAP unavailable. Hasn't been a good month for large-scale compute.

Sometimes co-authors ask me “did you see what they cited us for???” and of course I didn’t, because if you want to keep faith in humanity, you don’t look up what people cite you for, just like you don’t read comment sections.

Hadas Weiss@hadas.bsky.social · 3mo ago

Useful looking tool for finding variables across dbGaP and UK Biobank datasets querygap.org/explore

PLEASE SHARE: Serious request for a future scientific collaboration. Do I know any historians/sociologists who works with, or love working with historic ego documents. Diaries, letters, notes, etc. Especially those that describe real, or wished for, romantic partners/interests? email me, DM me!

Turns out empirically derived phenotypes (data-driven symptom sets) nested within traditional mental disorders can help reduce diagnostic heterogeneity! We learned so much cool and interesting stuff in this study. I could talk (/post) about it all day, but here’s a few highlights (🧵)

PsyArXivBot@psyarxivbot.bsky.social · 3mo ago

Empirically derived phenotypes can reduce diagnostic heterogeneity: https://osf.io/8wtqx