Leonard Frach

@leofrach.bsky.social

Postdoc in psychiatric genetics and clinical psychologist at University Hospital Bonn | PhD @ucl.ac.uk | Within-family analyses, statistical genetics, polygenic scores, behaviour genetics, epigenetics | he/him

One of my hardest and longest PhD challenges is coming to a close (well, almost). Very happy to finally share the preprint to our updated Gsens method! Major updates include the extension to multiple exposure scenarios, along with using raw data, estimating mediation effects and many more.

medRxivpreprint@medrxivpreprint.bsky.social · 3w ago

Genetic sensitivity analysis: estimating genetic confounding and environmentally mediated genetic effects using multiple exposures https://www.medrxiv.org/content/10.64898/2026.07.16.26358236v1

One of my hardest and longest PhD challenges is coming to a close (well, almost). Very happy to finally share the preprint to our updated Gsens method! Major updates include the extension to multiple exposure scenarios, along with using raw data, estimating mediation effects and many more.

medRxivpreprint@medrxivpreprint.bsky.social · 3w ago

Genetic sensitivity analysis: estimating genetic confounding and environmentally mediated genetic effects using multiple exposures https://www.medrxiv.org/content/10.64898/2026.07.16.26358236v1

🆕 New pre-print! osf.io/preprints/ps... Are you satisfied with your life because you are satisfied with your friends, health, job, etc.? Or is it actually the other way around: are some people generally satisfied with their life and, because of this, satisfied with their friends, health, job, etc.?

OSF

osf.io

Been saying this for years: Don't submit to Frontiers. Don't peer-review for Frontiers. It's long been considered a predatory publisher by many in the field, including many who have worked as editor there.

Michael Okun@michael-okun.bsky.social · 2mo ago

I’ve officially resigned as Associate Editor for Frontiers in Systems Neuroscience. It used to be a reputable journal, but became a case study in how forced automation destroys academic integrity. 👇

Are we still posting our raw datasets now that they're being farmed for genAI-written papers? I'm starting to feel differently now sharing data before I'm totally done with my own research questions...

🚨We have a fully-funded PhD scholarship (UCL/Birkbeck) starting October 2026 to look at how genetic, family, and social factors shape children’s language and literacy development. **Deadline 29th March**. Further details at bit.ly/40B2Wrx, please do get in touch if you are interested!

Untangling genetic and environmental pathways to language and reading development: Integrating social and genetic data from longitudinal cohort studies

Principal Supervisor: Dr Tim Morris (UCL) Co-Supervisors: Dr Emma Meaburn (Birkbeck); Professor Bonamy Oliver (UCL) Project Description Language and reading skills are key drivers of educational su…

bit.ly

Just posted a new preprint! We uncovered reproducible symptom‑based subtypes of depression. Findings include: • melancholic, atypical & psychomotor subtypes • links between insomnia + weight gain clusters and asthma • psychomotor clusters associated with Parkinson’s disease 🔗 doi.org/10.64898/202...

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1/4 Thrilled to be sharing new work published today in Nature describing the third wave of results from the PGC Cross-Disorder Group. This reflects a massive group effort to examine shared and unique genetic signal across >1 million cases for 14 psychiatric disorders. www.nature.com/articles/s41...

Mapping the genetic landscape across 14 psychiatric disorders - Nature

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders...

nature.com

I'm hiring! ✨ Looking for a Research Fellow to study environmental factors that mitigate intergenerational transmission of mental health. 3-year post at UCL @uclbrainscience.bsky.social with great opportunities for training, collaboration & exciting science! 🔗 Apply: www.jobs.ac.uk/job/DOZ633/r...

Research Fellow in Mental Health at UCL

Apply for the Research Fellow in Mental Health role on jobs.ac.uk, the top job board for academic positions in higher education. View details and apply now.

jobs.ac.uk

New paper out at the Journal of Psychopathology and Clinical Science! We examined unconditional & event-related changes in pathological vs normal-range personality using 4 metrics to compare their developmental links, how these vary with life events, and whether unique effects emerge across metrics

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