Masha Prager-Khoutorsky
@mashapk.bsky.social
Neurobiology of hypothalamus🧠, Associate Professor @mcgillu, mom to 👦🏻👦🏼🐶, microscopy geek🔬, and amateur baker🧁 and musician🎹 masha-prager-khoutorsky.lab.mcgill.ca
Targeting the brain's vasopressin neurons could be a novel treatment for high blood pressure 📹 Ning Gu et al @mashapk.bsky.social lab @mcgilluniversity.bsky.social in @cp-neuron.bsky.social ➡️ bpod.org.uk/archive/2025... with @rooph.bsky.social
Thrilled to share our new study showing microglia prune astrocyte processes in adult brain, to regulate synaptic transmission, hypothalamic neuron activity, and salt-induced hypertension in🐀. Huge team effort - congratulations to all🥂🍾🎉
Online now:
Microglial control of cerebral capillary basal tone. Congrats to @eyolab.bsky.social & team ! #cerebrovascular
Microglial cyclooxygenase-1 modulates cerebral capillary basal tone in vivo in mice - Nature Communications
The role of myeloid cells in vascular regulation remains incompletely understood. Here, the authors show that microglia are the only myeloid cells that localize to capillaries and that they maintain b...
nature.com
🧪 The Sjöström Lab in Montreal is looking for a postdoc! We study cortical circuits, synaptic plasticity, and NMDAR signalling using custom 2-photon microscopy and optogenetics. We seek candidates with strong patch-clamp and/or 2-photon imaging expertise, and a relevant publication track record.
Come join us at @mcgill.ca as an assistant professor in virus-host interactions! Please share widely. mcgill.wd3.myworkdayjobs.com/en-US/McGill...
Assistant Professor (Research), Department of Microbiology & Immunology, (C2-240724)
Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at ...
mcgill.wd3.myworkdayjobs.com
An iconic example of a successful combination of basic and clinical/translational research, offering real promise for treating a currently incurable disease #Fibromyalgia -congrats to all the authors🥂🍾👏🏽
Online now:
Excited to share our work by exceptional postdoc, Kyungdeok (KD) Kim. 2025 marks 10th anniversary of meningeal lymphatic discovery and I can’t be happier celebrating it with this work addressing how lymphatic dysfunction leads to cognitive deficits || www.sciencedirect.com/science/arti...
Meningeal lymphatics-microglia axis regulates synaptic physiology
Meningeal lymphatics serve as an outlet for cerebrospinal fluid, and their dysfunction is associated with various neurodegenerative conditions. Previo…
sciencedirect.com
Tenure track position in pharmacology or toxicology at McGill, in Montreal!!! www.nature.com/naturecareer...
Assistant / Associate Professor (Tenure Track), Department of Pharmacology and Therapeutics - Montréal, Quebec (CA) job with McGill University | 12837963
Faculty of Medicine and Health Sciences – Department of Pharmacology and Therapeutics, Toxicology (L000054
nature.com
So excited to share the work of the fantastic Katarzyna, 1st 🧪PhD student of my lab 🧠, out in @natureneuro.bsky.social 🥂🥳 Cheers to the team, thanks to our precious collaborators and support from @braincanada.bsky.social #CIHR @fondsrechercheqc.bsky.social #newPI www.nature.com/articles/s41...
Astrocytic cannabinoid receptor 1 promotes resilience by dampening stress-induced blood–brain barrier alterations - Nature Neuroscience
The mechanisms of neurovascular adaptations underlying stress resilience remain unclear. Here the authors show that the astrocytic endocannabinoid system modulates the blood–brain barrier changes duri...
nature.com
Our latest findings on social behavior circuits is out: how does the brain responds to social isolation? Terrific work by @dingliu.bsky.social et al. uncovering a circuit with similar neural architecture as physiological needs (hunger, thirst, sleep..). Detailed thread soon. rdcu.be/ebo63
A hypothalamic circuit underlying the dynamic control of social homeostasis
Nature - New data on brain-wide circuits centred around two interconnected hypothalamic neuron populations provide significant mechanistic insights into the emergence of social need during social...
rdcu.be
In our new preprint, we show that microglia can prune astrocyte processes to regulate synaptic transmission and hypothalamic neuron activity. This work represents a huge team effort spanning ~10 years, and we are very excited to finally share it with the world!
Microglia regulate neuronal activity via structural remodeling of astrocytes https://www.biorxiv.org/content/10.1101/2025.02.18.638874v1
Just bumping this up for those who may have missed earlier announcements-- we have a new PI position in the Neuroscience & Mental Health program here at SickKids. Neural and glial mechanisms in cognition.
Scientist/Senior Scientist – Research Institute, Hospital for Sick Children, University of Toronto – Canadian Association for Neuroscience
can-acn.org
Working on manuscript revisions during holidays🎄🎅🕎🍩🕯️ in 🇲🇽 with🍹🍸!!!
Huge congrats to Dr. Amirah Hicks on successfully defending her PhD! 🎉🥂👏 Amirah is my first trainee to earn a doctoral degree, and I couldn't be more proud of her accomplishments. I'm incredibly excited for the new chapter that lies ahead for her!