Spending great days with the 🇫🇷 glyco community of GFG. Honored to receive and share the Verbert-Fournet Award 2026 with my chem alter ego (and also roommate 😄), Ahmed El Rhaz. Congrats to @rebekkawild.bsky.social for the GFG 2026 Award, and to everyone for the quality of discussions. #glycotime

New piece from our lab: alpha-Gal syndrome from a glycobiologist's point of view. How glycans in ticks' saliva immunize us, and how our immune system responds to similar glycans present in red meat. Glycoproteins/glycolipids discussed. @alphagal-info.bsky.social tinyurl.com/55762ewu #glycotime

Day 2 of #CGS2026 was packed with 21 presenters and an engaging poster session, showcasing the incredible breadth of research happening in #glycomics and #glycoscience. The evening banquet was also a great opportunity to connect and continue conversations. #glycotime

My student Lena Nuschy giving her flash presentation about anionic glycan arrays at #CGS2026, organised by @glyconet_nce, in Canmore, Alberta

Yesterday we kicked off #CGS2026! It's fantastic to see strong engagement from the #glycomics community with over 190 attendees gathered from across Canada and internationally. Looking forward to a great few days of science, discussion, and new ideas! #glycotime #glycoscience

A great paper, with multiple approaches to characterise ST8Sia IV. #glycotime Polysialylation of HEK N-glycans, O-glycans, and even plant polysialylation. It would have been nice to see a little mass spec, but I'm biased :) pubs.acs.org/doi/full/10....

Polysialic Acid Synthesis on the N- and O-Glycans of Salmonid Polysialyltransferase ST8Sia IV

Extension of N- and O-glycans with linear sialic acid polymers (polySias) was described on a limited number of mammalian glycoproteins, including the α2,8-polysialyltransferases ST8Sia II and ST8Sia IV. Previous in vitro analyses have shown that ST8Sia IV from the salmonid fish Coregonus maraena (Cma) had high polysialylation activity and broader donor substrate specificity compared to its human counterpart. In this study, we investigated whether the fish ST8Sia IV was able to polysialylate N- and O-glycans of glycoproteins with a focus on its autopolysialylation capacity. Using a combination of strategies, including plant-based glycoengineering, we found that the Cma ST8Sia IV is able to use both types of acceptors for the formation of long polySia chains with a degree of polymerization of >40 consisting of N-acetylneuraminic acid and N-glycolylneuraminic acid. Given the importance of polySias in multiple health and disease states, the Cma ST8Sia IV represents a useful biocatalyst with applications in the fields of biosafe therapeutics and glycobiology.

pubs.acs.org

Excited to share some work that our lab co-led with @veredpk.bsky.social. Lots of data for anyone interested in Siglecs. Great work from Edward Schmidt with big support from @zeinab-jc.bsky.social. www.nature.com/articles/s41...

Congratulations to GlycoNet Investigator Dr. Matthew Macauley on receiving the Horace S. Isbell Award, recognizing his contributions to carbohydrate (sugar) research. Read more: https://canadianglycomics.ca/glyconet-investigator-receives-2026-horace-s-isbell-award/ #Glycotime #Glycoscience

Check out the super cool collaborative work with @elisafadda.bsky.social. Very cool modelling!

Elisa Fadda@elisafadda.bsky.social · 5mo ago

Wee thread 🧵⬇️ on our new #glycotime with @siglecdude.bsky.social John Klassen and @glycocode.bsky.social 🥳 where we show Siglecs as molecular precision tools, able to recognise sialylated glycans with surgical precision in their natural environment, not bad for a lectin! 😎 doi.org/10.1038/s420...

Wee thread 🧵⬇️ on our new #glycotime with @siglecdude.bsky.social John Klassen and @glycocode.bsky.social 🥳 where we show Siglecs as molecular precision tools, able to recognise sialylated glycans with surgical precision in their natural environment, not bad for a lectin! 😎 doi.org/10.1038/s420...

GlycoShape@glycoshape.org · 5mo ago

Silvia's simulations showed that while all epitopes expose Sia for binding, Siglec-6 recognises and binds only GM1 because of a key interaction with the membrane through W127 and K126, which orientates the V-set domain to bind the Sia through Arg122 and the terminal Gal to the C-C' loop 😎

Finally, an in-depth review #JBC about sialylation in cancer: dual role of sialyltransferases (the “writers”) and siglecs/selectins (the “readers”) in cancer progression. Must-read! tinyurl.com/yvauu3zj @mathd34.bsky.social @siglecdude.bsky.social #glycotime

On #WorldCancerDay 🎗️, our review on Writers and Readers of Sialylation in Immunoregulation in Cancer is out today in #JBiolChem: 🔗 www.jbc.org/article/S002... Follow for future experimental glyco-work from the @siglecdude.bsky.social lab 🔬🧫 #glycotime

Writers and Readers of Sialylation in Immunoregulation in Cancer

Sialic acids are the terminal monosaccharides of the glycocalyx that critically shape cell-cell interactions, and are strongly implicated in regulating immune recognition and tissue homeostasis. In ca...

jbc.org

Excited to share our laboratory's research tools to study Siglecs along with some interesting discoveries with these tools. Lot of help from many group, but @zeinab-jc.bsky.social was the major driver of this work. Please reach out if you would like to try them out. www.science.org/doi/10.1126/...

An ultrasensitive and modular platform to detect Siglec ligands and control immune cell function

Siglec-liposomes are a multivalent and modular platform for profiling Siglec ligands and modulating immune cell function.

science.org

An amazing week at University of Alberta 🇨🇦with plenty of #glycotime! A big thanks to @glycocode.bsky.social , @giaglyco.bsky.social and to @glyconet.bsky.social for the kind invitation!! Also great to see inspiring glyco-researchers that marked a generation

Great two glyco-days at #GIA2025 🍬 Honored to introduce Prof. Jim Paulson ⭐ Exciting glyco talks, amazing chats ☕, and valuable feedback for the next steps in my project 💡 #glycotime

Lara K. Mahal@glycocode.bsky.social · 9mo ago

Wonderful day 2 of #GIA2025 @giaglyco.bsky.social ! We started off with an outstanding talk from @salomepinho.bsky.social followed by a spectacular day of science with talks from @rlhull-meichle.bsky.social, Jason Northey, Alisdair Boraston and Trainees Sogand Makhsous and @mathd34.bsky.social!

Wonderful day 2 of #GIA2025 @giaglyco.bsky.social ! We started off with an outstanding talk from @salomepinho.bsky.social followed by a spectacular day of science with talks from @rlhull-meichle.bsky.social, Jason Northey, Alisdair Boraston and Trainees Sogand Makhsous and @mathd34.bsky.social!

Save the date for #GIA2026 (Nov. 5-6, 2026) which will feature free #glycotime talks by @carolynbertozzi.bskyverified.social , Dr. Mia Huang and more!

Amazing #glycotime immune research on display at GIA2025. Come join us at this free hybrid event and watch talk by some of the best in the field. Register here

Glycomics Institute of Alberta@giaglyco.bsky.social · 9mo ago

We’re thrilled to introduce GIA2025 Trainee Invited Speaker Dr. Jim Paulson, Professor Emeritus in the Department of Immunology and Microbiology at The Scripps Research Institute in La Jolla, CA who’ll talk on the roles of inhibitory Siglecs in regulation of immune responses! #GIA2025 #glycotime

Register for virtual or in person attendance for FREE at forms.gle/GGXwhBiRPgA9... #glycotime

Reminder that the deadline to submit an abstract to be considered for a 15 minute talk at GIA2025 is tonight! Don't miss out on presenting your glyco research and the opportunity to have lunch with Dr. Jim Paulson, our trainee-invited speaker! Link to submit: forms.gle/BdDTRsdXmTP9.... #GIA2025

We’re excited to invite you to the @giaglyco.bsky.social GIA2025 Symposium on Thursday and Friday, November 6–7. Registration is free and the event will take place in person and virtually for those joining online. glyco-alberta.ca/gia2025/ Come get the latest #Glycogang swag!

GIA2025

Join us for our fourth annual symposium, a celebration of knowledge and innovation in the field of glycoscience! Whether you’re an aspiring scientist or a seasoned researcher…

glyco-alberta.ca

🧪 Come join us for free #glycotime Register here for hybrid or in person attendance glyco-alberta.ca/gia2025/

Glycomics Institute of Alberta@giaglyco.bsky.social · 10mo ago

The countdown is on! With GIA2025 less than 3 weeks away, we’d like to introduce our Keynote Speakers that we will have the privilege of hosting this year. First is Dr. Sriram Neelameghan from the University at Buffalo whose lab studies the area of Systems Glycobiology. @neel-lab.bsky.social

🧬Power your research with GlycoNet Integrated Services’ Molecular Glycobiology node at the ‪@ualberta.bsky.social‬ Offering: Custom cell & mouse models (CRISPR, transgenics) Siglec-Fc protein production Cell engineering & expert support Explore more services: canadianglycomics.ca/services/

🚨 Just published in Mass Spectrometry Reviews! 🚨 Thrilled to share our latest review, summarizing over 20 years of work from the Klassen lab —plus insights from my own PhD research on COIN-nMS, SLOMO-nMS, and charge detection MS. analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...

Quantifying Protein–Glycan Interactions Using Native Mass Spectrometry

Interactions between glycan-binding proteins (GBPs) and carbohydrates (glycans) are essential to many biological processes relevant to human health and disease. For most GBPs, however, their glycan i...

analyticalsciencejournals.onlinelibrary.wiley.com

When glycan recognition is linked to immune response, you need fine tuning! 😎 Here ⬇️ we show how human Siglecs act as molecular precision tools, recognising the glycan and also the biological environment (or context) these glycans are found in. A 1/5 #glycotime🧵 ⬇️ doi.org/10.1101/2025...

🔬Meet Dr. @faezehjame.bsky.social‬ , a postdoc at SFU, studying how sugar molecules influence disease. Working in the Vocadlo lab, she is exploring how sugar molecules and the driving enzymes, glycosyltransferases, are involved in health and disease. Read: canadianglycomics.ca/trainee-at-g...

Good time at the Summer School in Structural Glycosciences organized by @glyco-alps.bsky.social and @anneimb.bsky.social . Was nice to visit the IBS, ESRF and CERMAV and meet a friendly glyco-community in Grenoble 🏔️

Excellent start for the 2025 session of our Structural Glycoscience Summer School with conférences and visit of @esrf.fr beamlines

Great few days in Maynooth for the 16th Jenner Glycobiology & Medicine Symposium. Grateful to have presented my work from the @siglecdude.bsky.social lab, connect with brilliant glyco-scientists, hear inspiring stories of pioneers, and enjoy Irish music & culture. 🇮🇪🎶🍻 #glycotime

Very excited to share some work the Lab has been working on for a while. A new platform to probe Siglec ligands. Led by an incredible PhD student (Zeinab). Comes out of an ongoing fruitful collaboration with the Derda lab. Very open to feedback! www.biorxiv.org/content/10.1...

An ultrasensitive and modular platform to detect Siglec ligands and control immune cell function

Siglecs are immunomodulatory receptors that regulate immune cell function. A fundamental challenge in studying Siglec-ligand interactions is the low affinity of Siglecs for their ligands. Inspired by ...

biorxiv.org