IGO Award (biennial), nominations of senior glycoscientists are requested by other senior figures in the field; no self-nominations are accepted. For the IGO Young Glycoscientist Award, applications are made by the candidates themselves, subject to limits on academic age. intl-glyco.org/procedure

This is the first @smartsymposium.bsky.social , Decoding the Glycome. We have lined up fantastic speakers, including experts in glycosylation and tool developers whose technologies hold exciting potential for applications in glycoscience. We look forward to welcoming you to Shenzhen this November

会议预告 | SMART Symposium：解码糖组—探索生物学未达之境

2026年11月16日-19日召开会议，2026年11月13日报名截止

mp.weixin.qq.com

Sharing our latest work on B cell Siglecs in regulating antibody production. Unlike our previous work (PMID: 35294874), where we found that CD22 (Siglec-2) positively impacts the germinal center (GC), our new work uncovers a regulatory role for Siglec-G in the GC: www.biorxiv.org/content/10.6...

Excited to share some work that our lab co-led with @veredpk.bsky.social. Lots of data for anyone interested in Siglecs. Great work from Edward Schmidt with big support from @zeinab-jc.bsky.social. www.nature.com/articles/s41...

Check out the super cool collaborative work with @elisafadda.bsky.social. Very cool modelling!

Elisa Fadda@elisafadda.bsky.social · 5mo ago

Wee thread 🧵⬇️ on our new #glycotime with @siglecdude.bsky.social John Klassen and @glycocode.bsky.social 🥳 where we show Siglecs as molecular precision tools, able to recognise sialylated glycans with surgical precision in their natural environment, not bad for a lectin! 😎 doi.org/10.1038/s420...

Interested in glycan-binding proteins in Immunity? Check out this review with Gabriel Rabinovich, @chrrademacher.bsky.social, and Mirta Schattner on this subject. www.annualreviews.org/docserver/fu...

Immune cells use sugar molecules on their surfaces to communicate—but these signals can be hard to study. GlycoNet researchers at @ualberta.bsky.social developed balloon-like probes to help detect these subtle interactions, opening doors for future therapies. 🔗 canadianglycomics.ca/balloon-like...

On #WorldCancerDay 🎗️, our review on Writers and Readers of Sialylation in Immunoregulation in Cancer is out today in #JBiolChem: 🔗 www.jbc.org/article/S002... Follow for future experimental glyco-work from the @siglecdude.bsky.social lab 🔬🧫 #glycotime

Writers and Readers of Sialylation in Immunoregulation in Cancer

Sialic acids are the terminal monosaccharides of the glycocalyx that critically shape cell-cell interactions, and are strongly implicated in regulating immune recognition and tissue homeostasis. In ca...

jbc.org

@pengwu.bsky.social put together a stellar lineup of speakers. Was just fun listening and fortunate to contribute.

Peng Wu@pengwu.bsky.social · 8mo ago

Nice discussions and turnover @pacifichem.bsky.social

Nice discussions and turnover @pacifichem.bsky.social

Come for the science. The location is pretty outstanding too.

GlycoNet@glyconet.bsky.social · 8mo ago

📢 Call for Abstracts now open! Submit your research to the 9th Canadian Glycomics Symposium (#CGS2026) and share your work with Canada’s glycomics community. 🗓️ Deadline: February 28, 2026 🔗 https://symposium.canadianglycomics.ca/abstract/ #Glycotime #CallForAbstracts #Research #STEM

Excited to share our laboratory's research tools to study Siglecs along with some interesting discoveries with these tools. Lot of help from many group, but @zeinab-jc.bsky.social was the major driver of this work. Please reach out if you would like to try them out. www.science.org/doi/10.1126/...

An ultrasensitive and modular platform to detect Siglec ligands and control immune cell function

Siglec-liposomes are a multivalent and modular platform for profiling Siglec ligands and modulating immune cell function.

science.org

When glycan recognition is linked to immune response, you need fine tuning! 😎 Here ⬇️ we show how human Siglecs act as molecular precision tools, recognising the glycan and also the biological environment (or context) these glycans are found in. A 1/5 #glycotime🧵 ⬇️ doi.org/10.1101/2025...

Very excited to share some work the Lab has been working on for a while. A new platform to probe Siglec ligands. Led by an incredible PhD student (Zeinab). Comes out of an ongoing fruitful collaboration with the Derda lab. Very open to feedback! www.biorxiv.org/content/10.1...

An ultrasensitive and modular platform to detect Siglec ligands and control immune cell function

Siglecs are immunomodulatory receptors that regulate immune cell function. A fundamental challenge in studying Siglec-ligand interactions is the low affinity of Siglecs for their ligands. Inspired by ...

biorxiv.org

New work on the structure of Siglec-10. Great collaboration that was solidified with a visit to Spain last year with fantastic discussions with June Ereno-Orbea and Jesus Jimenez-Barbero. Nice contributions on modeling by @elisafadda.bsky.social. www.biorxiv.org/content/10.1...

The unique molecular recognition features of Siglec-10: structural insights into sialoglycan and antibody interactions

Siglec-10 is a sialic acid-binding immunoglobulin-like lectin implicated in immune regulation, yet its molecular basis for ligand recognition and functional role in immune modulation remain poorly def...

biorxiv.org

A little story we put together that I hope can be useful: pubs.rsc.org/en/content/a.... More to come on this work related to this in the future.

Our review on the recent acceleration of research into carbohydrate Sulfation as as an enhancer of Siglec ligands: www.sciencedirect.com/science/arti...

Highly recommended listening to @ghazeskandari.bsky.social if you are interested in immune cells of the brain.

Canadian Neuroscience Seminars – Postdoctoral Series (CNS-PDS)@cns-pds.bsky.social · last yr.

Meet our first speaker 🗣️ Ghazaleh will be presenting at our webinar THIS Thursday! You can register here: zoom.us/webinar/regi... And remember, you can stay up to date on webinars, events, and more by subscribing to our mailing list: t.co/Oa9dLowy1h

We have a postdoctoral position open to help lead our CD33 project in microglia. Would be grateful if you could spread the word: macauleylab.ca/job-opening-...

Our latest work on Siglec binding to sulfated glycans. Great help: @khookh.bsky.social, @pengwu.bsky.social ,@raflynn5.bsky.social. Fom 1st PhD graduate of the lab (Jaesoo Jung) and help from Edward, Zeinab, Jhon, Kelli, @tayloregray.bsky.social, and Chris from my lab. pubs.acs.org/doi/10.1021/...

Understanding the Glycosylation Pathways Involved in the Biosynthesis of the Sulfated Glycan Ligands for Siglecs

Carbohydrate sulfation plays a pivotal role in modulating the strength of Siglec–glycan interactions. Recently, new aspects of Siglec binding to sulfated cell surface carbohydrates have been discovere...

pubs.acs.org

With the Wen lab and @siglecdude.bsky.social, we screening a library of sulfated glycan ligands against human Siglecs, and found that sulfation and sialylation patterns serve as important determinants of Siglec binding affinity and specificity #glycotime pubs.acs.org/doi/10.1021/...

Enzyme-Sialylation-Controlled Chemical Sulfation of Glycan Epitopes for Decoding the Binding of Siglec Ligands

Widely distributed in nature, sulfated glycan epitopes play important roles in diverse pathophysiological processes. However, due to their structural complexity, the preparation of glycan epitopes wit...

pubs.acs.org