Mathias Jucker
@mathiasjucker.bsky.social
Biomedical Researcher Professor @dzne.science @hih-tuebingen.bsky.social Tübingen 🇩🇪 & Zürich 🇨🇭
More evidence that Aβ seeds can trigger the full pathological phenotype of Alzheimer's disease!
JAMA Neurology@jamaneurology.com · 5mo agoPatients treated with cadaveric pituitary-derived human growth hormone contaminated with amyloid-β developed early-onset #AlzheimerDisease with prominent language deficits and histopathological features consistent with AD. ja.ma/4cdaqYk
as Research Briefing: A biomarker of Alzheimer’s disease could be a useful diagnostic tool for other amyloidoses www.nature.com/articles/s41...
A biomarker of Alzheimer’s disease could be a useful diagnostic tool for other amyloidoses - Nature Medicine
Increased blood levels of phosphorylated tau (p-tau) are a diagnostic tool in Alzheimer’s disease. In a multicenter, cross-sectional study, we show that serum p-tau could also serve as a biomarker for...
nature.com
Serum pTau levels are not specific to Alzheimer's disease and may also serve as diagnostic tool for other types of systemic amyloidosis, with potential utility in distinguishing amyloidosis-related polyneuropathy from other etiologies Mathias Jucker https://www.nature.com/articles/s41591-026-04272-2
DZNE research center@dzne.science · 6mo ago🩸 A blood protein seen as an early marker of Alzheimer’s 🧠may also play a role in other diseases: Researchers at DZNE and @hih-tuebingen.bsky.social found elevated phosphorylated tau (pTau) levels in two rare conditions affecting the heart 💓 and kidneys. 👉 www.dzne.de/en/im-fokus/...
Now published: Elevated blood p-tau 181 and 217 levels are not specific to Alzheimer´s disease and may also serve as a diagnostic tool of ATTR and AL amyloidosis! #alzheimer #biomarker. Wonderful collaboration with 3 European amyloid centers. @natmed.nature.com doi.org/10.1038/s415...
Blood phosphorylated tau elevation as a biomarker in immunoglobulin light chain and transthyretin amyloidosis - Nature Medicine
Elevated serum levels of phosphorylated tau are not specific to Alzheimer’s disease and may also serve as a diagnostic tool for the most common types of systemic amyloidosis, with potential utility in...
doi.org
It was great fun to measure NfL in all these species—not many people have the chance to analyze blood from elephants, crocodiles, lizards, and turtles. To better understand age-related changes and predict mortality across an even wider range of species, we now require additional samples.
PLOS Biology@plosbiology.org · 7mo agoBlood levels of #neurofilament light chain (NfL) increase with age in humans & predict #mortality. @mathiasjucker.bsky.social &co show that NfL age-related levels are comparable across mice, cats, dogs & horses, & may serve as a cross-species biomarker for #aging @plosbiology.org 🧪 plos.io/46iNxiX
![NfL levels in blood increase with age. Left: Mammalian species were grouped as young, adult, or aged depending on their known life expectancies. Shown are individual data points (y-axis (NfL [pg ml−1] on a log10 scale) with the median (red) and 95% confidence interval. Note that the sex was not known for 17 animals and that it was not possible to assign the sex to 316 of the aged humans. Right: Relationship between age [years] and NfL [pg ml−1] across the five species. Scatter points represent individual data, colored lines indicate generalized additive model (GAM) fits for each species.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:5522ztebtekoor5efelihqhb/bafkreih74jlprwzyypo5ho6hwu44am7vbhzm5iixegdxbzrilqynov7w44)
Neurofilament light chain may serve as a cross-species blood biomarker to assess aging and predict mortality. Carina Bergmann et al. PLOS Biology (2026). DOI: 10.1371/journal.pbio.3003606
Neurofilament Light (NfL) may serve as a cross-species blood biomarker for assessing ageing interventions and predicting mortality! #Wilhelma #Vetsuisse @plosbiology.org @dzne.science @hih-tuebingen.bsky.social @unituebingen.bsky.social I PLOS Biology: dx.plos.org/10.1371/jour...
Neurofilament light chain may serve as a cross-species blood biomarker to assess aging and predict mortality
Blood levels of neurofilament light chain (NfL) increase with age in healthy humans and can predict all-cause human mortality, but is this true across species? This study shows that NfL age-related bl...
dx.plos.org
We discovered these astrocytic inclusion over 25 y ago (e.g. DOI: 10.1126/science.1542796). Very satisfying to finally see the genetic linkage. Great work! The Smarcal1-Usp37 locus modulates glycogen aggregation in astrocytes of the aged hippocampus: Cell Systems www.cell.com/cell-systems...
The Smarcal1-Usp37 locus modulates glycogen aggregation in astrocytes of the aged hippocampus
Gómez-Pascual et al. identified that in the aged murine hippocampus, astrocytes with impaired autophagy accumulate polyglucosan bodies. Their burden, which is modulated by the Smarcal1-Usp37 locus, va...
cell.com
Vasiliki made the cover of the December issue www.cell.com/cell-reports...
Mathias Jucker@mathiasjucker.bsky.social · 9mo agoHuman – mouse chimeric cultures to study microglia and amyloid pathology; This is a very exciting approach with lots of potential. Congratulations to Vasiliki Panagiotakopoulou! Cell Reports www.cell.com/cell-reports...
Human – mouse chimeric cultures to study microglia and amyloid pathology; This is a very exciting approach with lots of potential. Congratulations to Vasiliki Panagiotakopoulou! Cell Reports www.cell.com/cell-reports...
Chimeric human organoid and mouse brain slice co-cultures to study microglial function
Panagiotakopoulou et al. developed a co-culture system combining human cerebral organoids and mouse brain slices. The model supports long-term study of human microglia, enhances cortical marker expres...
cell.com
Hopes that anti-#tau drugs could join those targeting #amyloid as treatments for #Alzheimers disease have been dented by the failure of a phase 2b trial of #JohnsonandJohnson's posdinemab.
J&J abandons Alzheimer's antibody in setback for tau
Hopes that anti-tau drugs could emerge as treatments for Alzheimer's have been dented by the failure of a phase 2b trial of J&J's posdinemab.
buff.ly
An excellent review of Abeta seeds by my current and former students and postdocs. Abeta seeds are becoming increasingly important as immunotherapy moves towards presymptomatic stages. doi.org/10.1111/jnc....
Amyloid‐β Seeds in Alzheimer's Disease: Research Challenges and Implications
The amyloid cascade hypothesis places amyloid-β (Aβ) at the center of Alzheimer's disease (AD) pathogenesis. Evidence suggests that AD progresses in two phases: an early phase driven by Aβ aggregatio...
doi.org
I'm curious to know if the microglia repopulation would also work via blood. - Brain-wide microglia replacement using a nonconditioning strategy ameliorates pathology in mouse models of neurological disorders | Science Translational Medicine www.science.org/doi/10.1126/...
Brain-wide microglia replacement using a nonconditioning strategy ameliorates pathology in mouse models of neurological disorders
A tricyclic depletion protocol allows for microglia replacement without preconditioning and mitigates pathology in mouse models of neurodegeneration.
science.org
Long-term full amyloid removal potentially delayed symptom onset and dementia progression! Findings from the DIAN study. sciencedirect.com/science/arti...
Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open-label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled ...
Amyloid plaque removal by monoclonal antibody therapies slows clinical progression in symptomatic Alzheimer's disease; however, the potential for dela…
sciencedirect.com
Join us for a Master's in Neuroscience in Tübingen, Germany. www.neuroschool-tuebingen.de/application/...
Great summary of the history of early growth hormone preparations and their link to iatrogenic CJD and Alzheimer. Unfolding story of protein mis-folding causing Alzheimer’s disease in recipients of human pituitary growth hormone. , doi.org/10.1210/jend...
The unfolding story of protein mis-folding causing Alzheimer’s disease in recipients of human pituitary growth hormone
Abstract. Human growth hormone (hGH) has been in clinical use for children with GH deficiency (GHD) since the late 1950s. The original formulations were co
doi.org
One more day to apply for these neurodegeneration professorships!
Mathias Jucker@mathiasjucker.bsky.social · 2y agoTwo flagship chair professorships for neurodgenerative diseases in Tübingen, Germany. Both affiliated with our university @hih-tuebingen.bsky.social and the German Center for Neurodegenerative diseases @dzne.science. Apply and join us! www.nature.com/naturecareer... www.nature.com/naturecareer...
Dear Donald Trump: A letter from Nature on how to make science thrive and why it matters for the health, prosperity and safety of people of America and the world 🧪 www.nature.com/articles/d41...
Dear Donald Trump: A letter from Nature on how to make science thrive
The US federal government can harness science to secure the health, prosperity and safety of Americans and the world.
nature.com
amazing! doi.org/10.1038/s415...
In vivo base editing extends lifespan of a humanized mouse model of prion disease - Nature Medicine
An in vivo base editing approach targeting the PRNP gene led to a 52% increase in the lifespan of mouse models inoculated with the most common sporadic and genetic types of human pathogenic prion isol...
doi.org
Two flagship chair professorships for neurodgenerative diseases in Tübingen, Germany. Both affiliated with our university @hih-tuebingen.bsky.social and the German Center for Neurodegenerative diseases @dzne.science. Apply and join us! www.nature.com/naturecareer... www.nature.com/naturecareer...
Nature Careers | Science jobs | Choose from 1,225 live vacancies
Search for your next job from 1,225 live vacancies, or upload your CV now and let recruiters find you
nature.com
What a cool read and quiz about confidence! Why probability probably doesn’t exist (but it is useful to act like it does)https://www.nature.com/articles/d41586-024-04096-5
Why probability probably doesn’t exist (but it is useful to act like it does)
All of statistics and much of science depends on probability — an astonishing achievement, considering no one’s really sure what it is.
nature.com
Two flagship chair professorships for neurodgenerative diseases in Tübingen, Germany. Both affiliated with our university @hih-tuebingen.bsky.social and the German Center for Neurodegenerative diseases @dzne.science. Apply and join us! www.nature.com/naturecareer... www.nature.com/naturecareer...
Nature Careers | Science jobs | Choose from 1,225 live vacancies
Search for your next job from 1,225 live vacancies, or upload your CV now and let recruiters find you
nature.com
Now that #lecanemab (#Leqembi) has been approved in Europe, we have updated our #Alzheimer game! Play and find out when is the best time to start immunotherapy. Play at --> hih-tuebingen.de/alzheimer/game
Trajectories of neurofilament light chain (a presumed marker of neurodegeneration) in CSF and blood over the entire course of (autosomal dominant) #Alzheimer's. doi.org/10.1038/s414.... Great collaboration with Dominantly Inherited Alzheimer Network (DIAN) @dzne.science @hih-tuebingen.bsky.social
Comparative neurofilament light chain trajectories in CSF and plasma in autosomal dominant Alzheimer’s disease - Nature Communications
This study supports neurofilament light chain protein (NfL) in both cerebrospinal fluid (CSF) and blood as an early marker of neurodegeneration in Alzheimer’s disease but suggests that NfL in CSF may ...
doi.org
