Matilde Galli
@matildegalli.bsky.social
Cell cycle / Developmental timing / polyploidy Favorite model: C. elegans Group leader @hubrechtinstitute.bsky.social
Be on the lookout for an exciting meeting that Matilde @matildegalli.bsky.social , Silvia @santoslab.bsky.social and I are organizing next year in Amsterdam. It will be a lot of fun. coming-soon.embo.org/w27-24
Cycling towards fate: cell-cycle control in development
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coming-soon.embo.org
Is the bottom image really C. elegans? I've worked with them for more than 15 years, this is not what they look like! BTW - the conclusion of the article is not that model organism research is fading, but rather that it is becoming a smaller fraction of all the research that is being done!
An analysis of published papers on eight widely studied “model” organisms suggests work on them is fading, but not everyone is worried. https://scim.ag/3PaOvIs
I'm excited to share our work on the regulation of endomitosis in worm intestines: www.biorxiv.org/content/10.1... We find that cells are able to uncouple nuclear division from cell division by transcriptional repression of key cytokinesis regulators
Transcriptional repression of central spindle factors controls endomitosis in the C. elegans intestine
During development, many cell types transition from canonical to non-canonical cell cycles, suchas endomitosis and endoreplication, in which they duplicate their DNA but do not divide, giving rise to ...
biorxiv.org
Great thread summarizing a recent provocative (and insightful!) paper "Cell cycle duration determines oncogenic transformation capacity" (pubmed.ncbi.nlm.nih.gov/40307557/) We clearly need to understand more about cell cycle timings in different cell types!
To better treat cancer, we need to understand its underlying biology. Despite decades of research, some fundamental questions remain unanswered. One is why certain key tumor suppressor or oncogenes lead to cancer predominantly in single tissue: e.g. Rb in the retina, or APC in the colon 1/n 🧪
My friend @aniekj.bsky.social is not going to like this 😅 (Unless fly people have something similar with worms?) #worm25
I'm so happy and proud to be part of the worm community! #worm25
Go worms! #worm25
🤔 Equal treatment... Perhaps reconsider extension rules for eligibility for applying to ERC @erc.europa.eu grants? LGBTIQ (non-biological) parents get 0 months extension (compared 18-months for biological mothers) FYI: the Dutch Research Council (NWO) gives 6 months to all non-biological parents
Diversity is our strength❤️🧡💛💚💙💜 On #IDAHOT, we reaffirm our commitment to end violence and discrimination against LGBTIQ people — and raise the progressive flag at our headquarters. Respect for fundamental rights and equal treatment are key pillars of our Union.
Fun Q&A with Curr Bio in which I discuss mammoths, Don Quijote, and why you should not fall in love with a hypothesis authors.elsevier.com/a/1l2MF3QW8S...
authors.elsevier.com
🔥New Night Science paper!! Discovery happens when your initial plans fall apart but it requires you to have a particular mindset: it's not extraverted, orderly, neurotic or agreeable that's the most important – discovery requires an OPENNESS to new ideas and unexpected insights.
Such a fun movie from the @hubrechtinstitute.bsky.social featuring two PhD students in my lab @sonvelt.bsky.social and @divm-science.bsky.social
We challenged our researchers to describe their work in 10 words or less. See how they did in this video!
Wow, this is so cool 🤯
1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬 But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯 Our new study reveals how retrotransposons invade the germline directly from somatic cells. www.biorxiv.org/content/10.1... A short thread 🧵👇
Together with fellow @biologists.bsky.social EiCs we've written about the unprecedented cuts & policy changes to research in the US We stand with our US colleagues during this challenging time Science transcends borders—setbacks in one nation affect us all journals.biologists.com/dev/article/...
Science under siege: protecting scientific progress in turbulent times
As Editors-in-Chief of The Company of Biologists' journals, we have been watching with growing concern the policy changes in the United States of America (USA) and the challenges that these are creati...
journals.biologists.com
Today I say goodbye to my last two wisdom teeth. I hope there is still some wisdom left in me
This Editorial by Brandon S. Gaut and Claudia A. M. Russo provides some nice insight into how #SocietyJournals work, and why it pays for Scientists to publish with #SocietyOwned Journals. 👇 A Message From the Editors-in-Chief academic.oup.com/mbe/article/... #PlantScience #SciencePublishing
A Message From the Editors-in-Chief
We have been Co-Editor-in-Chiefs of Molecular Biology and Evolution (MBE) for 2 years now. In that time, we have learned a great deal about the science of
academic.oup.com
Many US students don’t know how to seek opportunities outside the US. With some help from our colleagues in EU and Canada, we could put together a consolidated website of PhD opportunities and scholarships outside the US, organized by field. There might still be time for this year in some places.
I’m having similar conversations and sharing international opportunities a lot. I’m sure for a lot of US based trainees that feels overwhelming. I moved to Europe for my postdoc.Happy to chat with any trainees about my experience if it would be helpful.
Today, I registered for the 2025 International Worm Meeting and I also voted for my favorite invertebrate here (I voted for another worm than on the pic😉) www.theguardian.com/environment/...
Nominate your invertebrate species of the year
We’re asking readers from around the world to nominate their favourite spineless species for our second Invertebrate of the Year competition
theguardian.com
It's interesting to see that European countries have such different views on the value of science.. (especially as an Italian living in the Netherlands, I feel a bit split..) media.springernature.com/full/springe...
A very clear (and scary) summary of what's happening at US research institutions and universities
Here’s a gift link. This is a good one to share with your non-scientist friends and family www.nytimes.com/2025/02/14/o...
Join us in Paris 6-9 May 2025 for the #EvoDevoTempo conference (2nd edition) with a fantastic line up of speakers confirmed!! Organized by @mdiazcuadros.bsky.social @vanderhaeghenp2.bsky.social @bassemh.bsky.social and me. Please RT to spread the word meetings.embo.org/event/25-dev...
Developmental timing across species: From mechanisms to evolutionary insights
Like choreography, development consists of a highly ordered suite of steps and transitions. Modifying developmental tempo can affect final size and composition of tissues, as well as their plasticity…
meetings.embo.org
An inspiring interview for future scientists: my friend and colleague Francesca Mattiroli @fmattiroli.bsky.social recently got tenured at the Hubrecht and reflects on her journey ❤️ www.hubrecht.eu/francesca-ma...
Francesca Mattiroli got tenure: ‘Science is a team sport’ - Hubrecht Institute
She always dreamed of becoming a scientist. Francesca Mattiroli, has passed tenure evaluation with flying colors. She will expand her chromatin research.
hubrecht.eu
Wow 😳! I thought science in The Netherlands was in a bad spot after the Dutch elections but I guess it could be worse.. www.science.org/content/arti...
Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring
Researchers facing
science.org
Very happy to share our preprint on visualizing the life cycle of Influenza viruses using single-molecule imaging! 🥳 We developed two techniques to visualize infections of unmodified influenza viruses in live cells from endosomal release to budding of new viruses. For more details&videos see below ⬇️
I am really happy to announce the first Hubrecht Symposium on March 13th 2025! We will organize these yearly events on a specific topic in molecular and developmental biology to emphasize the importance of fundamental research for Dutch science. Free of charge! www.hubrecht.eu/hubrecht-sym...