Max Telford

@maxjtelford.bsky.social

Zoologist and evolutionary biologist. Interested in animal phylogeny. At UCL. Author of 'The Tree of Life: Solving Science's Greatest Puzzle'

Thrilled to post thread re: new single-cell lineage of mouse embryo reconstructed w/ DNA Typewriter. One animal, zygote to late organogenesis (E13.5). Tree has 1,340,794 transcriptionally profiled, annotated tips (cells), 1,142,588 dated internal nodes, rooted at zygote 1/n

McDermott et al. (2026-07, Proceedings of the Royal Society B: Biological Sciences) 「動物における対称性の進化に対する形態系統学的アプローチ」 A morphological phylogenetic approach to the evolution of symmetry in animals doi.org/10.1098/rspb... うおおおおおおお!!!!!

James W. McDermott et al., CC BY 4.0, https://doi.org/10.1098/rspb.2026.1111

22 years ago today, Francis Crick died. You can read about his life, his brilliance and his failures in my biography, available in hardback in the UK and USA (and as an audiobook and ebook) and soon in a chonky UK paperback.

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Thoroughly enjoyed this. Lots of science, and it prompted me to read some of Crick's original writing. He had that incredible insight, like Turing, into the implications of his work and others'. Plus a fun puzzle trying to work out who some of his secret lovers were, with the aid of Google.

Matthew Cobb@matthewcobb.bsky.social · last wk.

22 years ago today, Francis Crick died. You can read about his life, his brilliance and his failures in my biography, available in hardback in the UK and USA (and as an audiobook and ebook) and soon in a chonky UK paperback.

🔬 Meet Kevin Grüner, DC in the ZooCELL team at IGFL! Kevin completed his BSc in Biology and MSc in Zoology at the Uni. of Innsbruck, where he also worked at the EM facility and tutored different courses. He is now a DC in ZooCELL, investigating limb regeneration. 🧵 Read on to get to know Kevin.

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HELP? Trying to get original, untrimmed alignments from this paper. Have looked very hard. Anyone able to help?? Philippe et al. Multigene analyses of bilaterian animals corroborate the monophyly of Ecdysozoa, Lophotrochozoa, and Protostomia Mol Biol Evol. 2005 May;22(5):1246-53.

1/ Deep-time phylogenetics is hard: overly simplistic substitution models can mislead tree estimation at the billion year timescale. Our new preprint introduces GTRspmix, a protein modeling framework designed to more realistically model site-to-site heterogeneity in amino acid replacement. 🧵

The first single-cell three-dimensional lamprey brain atlas reveals that the vertebrate common ancestor already had a highly regionalized brain, and subsequent neuronal specialization likely drove vertebrate brain diversification. Learn more this week in Science: https://scim.ag/4whLqXp

As living fossils, lampreys, such as this Far Eastern brook lamprey (Lethenteron reissneri), provide an irreplaceable model for reconstructing the ancestral vertebrate brain. The first single-cell three-dimensional lamprey brain atlas reveals that the vertebrate common ancestor (~500 million years ago) already had a highly regionalized brain, and subsequent neuronal specialization likely drove vertebrate brain diversification.

Photo: Nobuhiko Akiyama/Minden Pictures