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Martin McGavin

@mcgavlab.bsky.social

Prof in Microbiology and Immunology at University of Western Ontario. Studying Staph aureus and how it senses and responds to chemical signals from innate immunity.

67 Posts92 Follower116 Folgt
Brian Wilde@bwildemtl.bsky.social · last wk.

83 to go. The Canadiens open their season with a mature effort. It wasn’t spectacular but it was an intelligent road game. The win in Toronto in the season opener of the Call Of The Wilde for Global Montreal globalnews.ca/news/1207663...

Call of the Wilde: Montreal Canadiens start the season with a tight victory over the Maple Leafs in Toronto - Montreal | Globalnews.ca

The Montreal Canadiens drew the Maple Leafs in Toronto and it was a match-up that Montreal has struggled with, but not this time. The Canadiens posted a tight 3-2 win.

globalnews.ca

anna brogan@apbrogan.bsky.social · 2mo ago

This is now published! For those interested in microbial mechanotransduction: www.cell.com/current-biol...

Microbial GAIN domains undergo autoproteolysis and enable release of diverse cell-surface-associated proteins

Brogan and Rudner report the identification of a microbial autoproteolytic domain that is structurally homologous to the GAIN domain of eukaryotic adhesion GPCRs. Rather than participating in transmem...

cell.com

anna brogan@apbrogan.bsky.social · 5mo ago

My latest work! We found that the autoproteolytic GAIN domain which mediates force responsive signaling in adhesion GPCRs is not unique to eukaryotes. The microbial counterparts anchor diverse adhesion, enzymatic, and toxin domains to the cell surface, enabling release by likely mechanical stimuli.

Omar El-Halfawy@omarel-halfawy.bsky.social · 3mo ago

Thrilled to share our recent paper at @cellpress.bsky.social's @cp-iscience.bsky.social studying the antibiotic responses of MRSA, one of the most common wound pathogens, under wound infection-like conditions vs. standard lab test conditions. www.cell.com/iscience/ful...

Uncovering the mechanisms of clinically relevant altered antibiotic responses of Staphylococcus aureus under wound infection-mimetic conditions

Biophysics; Clinical microbiology; Microbiology; Molecular biology; Systems biology

cell.com

Brian Wilde@bwildemtl.bsky.social · 5mo ago

The playoff views is when we prove to them it’s financially viable to pay a writer. I ask humbly … keep those reposts coming for circulation Thank you and go Habs Go

Brian Wilde@bwildemtl.bsky.social · 5mo ago

The Canadiens were flying right from the get-go. All the heroes. I finally wade in on what is ailing Caufield, and the Wilde Cards is a plea to fans. The Call Of The Wilde is brought to you by Global Montreal. globalnews.ca/news/1183762...

Martin McGavin@mcgavlab.bsky.social · 6mo ago

Happy to share @McGavlab most recent work in J. Bact. journals.asm.org/doi/10.1128/... from PhD candidate Tika Thapa, assisted by Dr Robert Kuiack. Here we show that Staph aureus and Staph epidermidis exhibit differential responses to acidic pH and C16 fatty acids that would be encountered on skin.

Differential pathogenic and commensal response of Staphylococcus aureus and Staphylococcus epidermidis toward chemical signals of human skin | Journal of Bacteriology

Human skin is a chemically hostile environment, with acidic pH and antimicrobial fatty acids that challenge microbial survival. Understanding how closely related Staphylococcus epidermidis and Staphylococcus aureus navigate these conditions is critical for distinguishing commensal behavior from pathogenic potential. Our research reveals that S. aureus and S. epidermidis, although genetically similar, employ markedly distinct adaptive mechanisms in response to identical skin-derived cues. Specifically, each species remodels its membrane phospholipids in unique ways under acidic pH and C16 fatty acid exposure. These environmental factors also differentially modulate their biofilm formation and protease activity. Together, our findings highlight how the same host-derived chemical signals of skin can activate virulence-associated traits in S. aureus while supporting commensal persistence in S. epidermidis.

journals.asm.org

Martin McGavin@mcgavlab.bsky.social · 10mo ago

Happy to see our collaboration with @larocklab.com in print! Great work from @larocklab.com group to show that Staphopain A cysteine protease (ScpA) of S. aureus initiates pyroptosis in keratinocytes through proteolytic processing of Gasdermin A. www.nature.com/articles/s41...

Staphylococcus aureus induces Gasdermin A-dependent keratinocyte pyroptosis - Nature Communications

The cell death effector Gasdermin A is only known to be activated by Streptococcus pyogenes. This work discovers a mechanism for its activation by Staphylococcus aureus, and shows a conserved role in ...

nature.com

Patrick Moynihan@pmoyniha.bsky.social · 10mo ago

If you or someone you know is looking for a post-doctoral position working on mycobacterial envelope biology, please get in touch. I am recruiting here at the University of Western Ontario in London, Ontario, Canada.

Martin McGavin@mcgavlab.bsky.social · 11mo ago

ournals.asm.org/doi/10.1128/spectrum.02278-25?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed Pleased to present our latest work from Doctoral candidate Camryn Bonn. Emergence of S. aureus strains with increased resistance to antimicrobial fatty acids.

Widespread emergence of Staphylococcus aureus with variant FarR regulators and enhanced resistance to antimicrobial fatty acids within clonal complex CC5, CC8, and CC97 strains from human and bovine h...

Staphylococcus aureus is a priority pathogen for the World Health Organization due to its association with human morbidity, mortality, and acquisition of multiple drug resistance. In addition to acqui...

ournals.asm.org

Joanne Flynn@joanneflynn19.bsky.social · last yr.

We are hiring! The Dept of Microbiology and Molecular Genetics is looking for faculty at the Assistant or Associate professor level (tenure track). Please consider joining our vibrant microbiology and immunology community at the University of Pittsburgh School of medicine

Ferric Fang, MD@fangferric.bsky.social · last yr.

Two Harvard economists forecast the impact of the administration’s proposed NIH budget cuts- stunning losses in new therapies, life expectancy, and economic output with a “social cost 16 times greater than the savings the administration is attempting to achieve." jamanetwork.com/journals/jam...

Cutting the NIH—The $8 Trillion Health Care Catastrophe

This JAMA Forum discusses the recent budget cuts to National Institutes of Health (NIH), the effects of these cuts on scientific research and health of individuals in the US, and the prospects for cha...

jamanetwork.com