Review alert! Our new review titled 'The dynamic tumor extracellular matrix: Biophysical cues, cellular crosstalk, and disease progression,' is now online! Congrats to all the authors! Link: tinyurl.com/bdh6zzzp

The dynamic tumor extracellular matrix: Biophysical cues, cellular crosstalk, and disease progression

The interplay between diverse cell types and their extracellular matrix (ECM) is fundamental for multicellular life. The ECM is a complex meshwork of …

tinyurl.com

🚨 We are hiring TWO postdocs to join the Cell Migration Lab (cellmig.org) 🇫🇮 as part of the new Centre of Excellence in Immune–Endothelial Interfaces (IMMENs). Join us to decode immune regulation & develop next-gen imaging tools! 🧪🔬 Details in thread 🧵👇 #ScienceSky #Postdoc #AcademicJobs Please RT🫶

CELL MIGRATION LAB

We study cell migration in health and disease

cellmig.org

Postdocs wanted - Please spread the word! We are looking for one bioinformatician and 1-2 cell biologists with different expertise! See the job ad below for more information and links to the job descriptions!

Come and work with us, We are looking for a new group leader at Turku Bioscience @turkubioscience.bsky.social. Åbo Akademi University invites applications for a fixed term position as Head of Research in Bioscience (Principle Investigator). abo.rekrytointi.com/paikat/?o=A_...

Very happy to share Niklas Jäntti's PhD work on EPLIN /LIMA1 isoforms (α/β) in breast cancer (spoiler: both have opposing roles in integrin traffic, cell migration & clinical outcome). This might explain why EPLIN sometimes has been reported as pro- and sometimes as anti-tumorigenic: bit.ly/3Iwjtau

EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration

Epithelial protein lost in neoplasm (EPLIN), an actin-binding protein, has been described as both a tumor promoter and tumor suppressor in different c…

bit.ly

We are very proud to announce @johannaivaska.bsky.social as the recipient of the Biennial Finnish Science Award, given by the Finnish Ministry of Education & Culture. Johanna was described as a distinguished researcher with pioneering work in cell biology. Warmest congrats from all of us, boss!

New paper from @ivaskalab.bsky.social out now! 🍾 Watch how cancer cell adhesion dynamics are disrupted by inhibiting the phosphatase Shp2 - key to integrin β1 phosphorylation. Blocking Shp2 impairs adhesion and reduces invasion potential. 🎥👇 Read more at: www.nature.com/articles/s41...

Congratulations to Pat Caswell (@integrintraffic.bsky.social) & Alexandra Naba (@matrisome.bsky.social) who will be vice-chairs of the 2027 Fibronectin, Integrins & Related Molecules GRC and chairs of the 2029 meeting!

Happy to share our Tensin 1 phase separation project is now on bioRxiv. www.biorxiv.org/content/10.1... This wouldn't be possible without @johannaivaska.bsky.social @ivaskalab.bsky.social #VattulainenLab #MSCA by @ec.europa.eu @turkubioscience.bsky.social @inflames-flagship.bsky.social

Adhesion-derived condensates control component availability to regulate adhesion dynamics

Integrin adhesion complexes mediate cell-extracellular matrix (ECM) interactions and undergo dynamic remodelling to regulate cell adhesion and migration. Here, we demonstrate that tensin 1 (TNS1), a m...

biorxiv.org

Our lab's #1st manuscript from our #1st #PhD Katie is on #bioRxiv! Check it out 👇🏻 #macrophage regulation of fibroblast #collagen #circadian rhythm. #ImmunoECMatrix w/ @profandrewmac.bsky.social @tracyh9494.bsky.social @mcrcellmatrix.bsky.social @mcf-uom.bsky.social www.biorxiv.org/content/10.1...

Macrophages promote collagen deposition through circadian regulation of fibroblasts

Collagen deposition in fibroblasts, the primary collagen-producing cells, is regulated by both macrophages and the circadian rhythm, although how these regulatory processes interact with one another i...

biorxiv.org

Maybe of interest to the talented ECR network of @themeshwork.bsky.social ? www.manchester.ac.uk/research/bic...

Bicentenary PhD Studentships and Fellowships | The University of Manchester

Learn more about the Bicentenary PhD Studentships and Fellowships launched as part of The University of Manchester's 200th year.

manchester.ac.uk

#ECMatrix researchers, please share: Just under 2 weeks until the abstract deadline (21st Feb) for the 3-day Matrix Nexus meeting in Freiburg. Topics include #cancer #collagens #proteoglycans #proteases #tissueengineering & a session dedicated to #ECRs! www.matrixbiologie.de/annual-meeti...

🚀 SAVE THE DATE! The 4th BioImage Informatics Finland (BIIF) Symposium is happening 📅 May 22-23, 2025! Join researchers & facility experts to discuss the latest in image analysis & data management. 📍Seili, Turku Archipelago 🇫🇮 Stay tuned for program & registration #BIIF2025 Photo: Visit Seili

I put together a small guide on how to get started with Fiji. Please distribute to anyone who might benefit form this! zenodo.org/records/1477... #imageanalysis #fiji #imagej #training

The deadline for abstract submission has now been extended until the 10th Feb!

Megan Chastney@mchastney.bsky.social · 2y ago

For early career researchers interested in the Fibronectin, Integrins and Related Molecules GRS/GRC this May, don’t forget to sign up! The deadline for submitting an abstract to be considered for an oral presentation for the GRS is less than a week away! Register here: www.grc.org/fibronectin-...

We are hiring!! How do basement membranes become stable structures during tissue growth? How can we measure turnover and dynamics? Come and join our team to help us answer these questions! @mcrcellmatrix.bsky.social @stramerlab.bsky.social More info 👇 www.jobs.ac.uk/job/DLN927/r...

Research Associate - Mechanisms Associated with Extracellular Matrix Assembly and Stability at The University of Manchester

Apply for the Research Associate - Mechanisms Associated with Extracellular Matrix Assembly and Stability role on jobs.ac.uk, the top job board for academic positions in higher education. View details...

jobs.ac.uk

A reminder to colleagues interested in Cell-Matrix adhesion & anything ECM related that registration is now open for the Fibronectin, Integrins & related molecules Gordon Research Conference. Incredible list speakers! incredible location! it will 🔥 🔥 🔥 Please join us! www.grc.org/fibronectin-...

For early career researchers interested in the Fibronectin, Integrins and Related Molecules GRS/GRC this May, don’t forget to sign up! The deadline for submitting an abstract to be considered for an oral presentation for the GRS is less than a week away! Register here: www.grc.org/fibronectin-...

Very glad to see this study finally out (and mentioned on bsky already!)- it's been a huge #collaboration across different groups🙏🏻 Fibroblasts recycles (in a #circadian manner) #collagen to make new fibrils, which is enhanced in #fibrosis. doi.org/10.7554/eLif... @elife.bsky.social

Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis

Secretion and fibrillogenesis of collagen-I are separately controlled molecular pathways in the fibroblast, where surprisingly endocytic recycling is required for fibril formation and is increased in ...

doi.org

📣 Everything you always wanted to know about the #ECM (but were afraid to ask). Join me at @themeshwork.bsky.social seminar series in December to learn about the latest developments of the #Matrisome project @matrisome.bsky.social! Sign up here forms.gle/W3QFUheh9hf5... and help us spread the word!

Here is the most recent preprint from our most recent PhD graduate, Dr Nicolas Pasquier. Orientation of mucinous CRC apicobasal polarity is regulated by tumor-stroma interactions. This work was a collaboration with the Jaulin lab at the Gustave Roussy Institute. www.biorxiv.org/content/10.1...

Signaling downstream of tumor-stroma interaction regulates mucinous colorectal adenocarcinoma apicobasal polarity

Mucinous colorectal carcinoma (MUC CRC) dissemination into the tumor stroma and metastasis to multiple organs, including the peritoneum, is associated with poor prognosis. Disseminating MUC CRCs exhib...

biorxiv.org

Delighted to share our latest paper: "The glomerular circadian clock temporally regulates basement membrane dynamics and the podocyte glucocorticoid response" Expertly led by Rebecca Preston & in collaboration with clock superstar Qing Jun Meng pubmed.ncbi.nlm.nih.gov/39515644/ Key findings 👇👇

Introductory post on 🦋! We're a research group headed by Prof. Johanna Ivaska interested in understanding how integrins contribute to every step of cancer progression. We're located at the Turku Bioscience Center in Turku, Finland! Find out more about us and our interests here: ivaskalab.utu.fi

Ivaska cell adhesion and cancer Lab

Integrins, matrix, motility and mechanotransduction in cancer

ivaskalab.utu.fi