Bladder dysfunction affects approximately 30% of stroke survivors. Our very own Kay Jann, PhD, spoke with Diagnostic Imaging about using brain MRI to guide treatment for bladder dysfunction after stroke. 🧠 Check out the interview: bit.ly/45JQdFv

Can Brain MRI Help Predict Spinal Cord Stimulation Response for Treating Urinary Incontinence in Stroke Survivors? | Diagnostic Imaging

In a recent interview, Kay Jann, PhD, discussed challenges with urinary continence in stroke survivors and a forthcoming NIH-funded study examining the use of brain MRI to help identify those who may ...

diagnosticimaging.com

Read more about our recent paper here ⬇️

USC INI@uscini.bsky.social · last wk.

Depression may be linked to changes in a specific part of the brain’s memory center. Our researchers studied more than 2,000 cognitively healthy older adults and found that depression was associated with smaller volume in a hippocampal area important for retrieving memories. Read more bit.ly/4q9xmxe

🚨New paper alert! "Depression and hippocampal subfield volume in older adults" in Translational Psychiatry Highlights: 👀 ⬇️ Read more: bit.ly/4we8ruq Led by: USC NGP student Danielle Luu

At AAIC? Please check out a few posters from our lab.

Congrats to the amazing Koral Wheeler and the other USC graduates! So glad I got to share this milestone celebration with her 🎉🎓

📣 HABS-HD R8 measures for sMRI & amyloid and tau PET are now available on the LONI IDA! New from our lab: 🧠 Centiloids for global amyloid. 🧠 Tau SUVR in the mesial temporal lobe region we used to tau positivity (doi: 10.1162/IMAG.a.41). 🧠 Detailed analysis protocols. @uscini.bsky.social

🚨 Our NEW study from Koral Wheeler-Bacani, MS, and @meredithbraskie.bsky.social found early Alzheimer's disease-related brain changes may appear differently across racial and ethnic groups. Read the press release 👉 bit.ly/46VvzDu and check out our animation of the data 🧠

🚨 NEW study out in Alzheimer's & Dementia from our very own @meredithbraskie.bsky.social & Amaryllis Tsiknia 🧠 Learn how subtle changes in how blood flows through the brain and how brain tissue uses oxygen may be closely linked to Alzheimer’s disease risk Press release: bit.ly/46UqkUu

It's public! I sold a book! Super psyched to join Ruadán, and to share Spit and Touch Iron with you all.

Ruadán Books@ruadanbooks.bsky.social · 6mo ago

We're pleased to announce that we will be publishing @michaelstrode.bsky.social's debut novel SPIT AND TOUCH IRON! This speculative historical thriller is a mashup of Sherlock Holmes with Celtic folklore, set in post-WWII rural Ireland: read more at the press release. links.ruadanbooks.com/strode

Out with the old and in with the new. This little guy was shedding its skin and 2025 both. Happy New Year, everyone! 🎉

How cool is this new work from the Bienkowski lab? CA1 of mouse hippocampus has 4 layers of specialized cell types. "This...changes our understanding of how information is processed...and could explain why certain cells are more vulnerable in diseases like Alzheimer’s and epilepsy." Read more ⬇️

USC INI@uscini.bsky.social · 9mo ago

🚨 Our latest study from @neuralmapping.bsky.social and his team is out in @nature.com and reveals a hidden set of cellular layers inside the hippocampus, the brain’s key center for learning and memory 🧠 Learn more about this work and its implications for memory and disease: bit.ly/48NtGdf

Come visit Suchita Ganesan at her SFN poster today from 1-5 pm: "Hemoglobin in relation to structural and fluid markers of neurodegeneration across a multi-ethnic cohort." Poster D4 @uscini.bsky.social

At SFN? Come check out Sam Nimmo's poster at D6 from 1-5 pm today: "The relationship between anxiety and brain amyloid levels in cognitively unimpaired older adults" @uscini.bsky.social

Scene from Max Hand's SFN poster yesterday, when he presented his poster "Cross-sectional model and predictors of cognitive resilience in an ethnoracially diverse cohort." @uscini.bsky.social

🚨New paper alert! Looks at how amyloid, tau, & neurodegeneration vary by ethnoracial group & sex in Hispanic & non-Hispanic Black & White adults from HABS-HD. Led by Dr. Michelle Caunca in Dr. Kristine Yaffe's lab. Read here ➡️ bit.ly/4gUbwJi @uscloni.bsky.social

Neuroimaging markers of dementia across race/ethnicity and sex/gender using an intersectional approach within the HABS‐HD cohort

INTRODUCTION Racial/ethnic and sex/gender differences in neuroimaging markers of dementia have been previously explored, but rarely with an intersectional approach. METHODS Using data from the Hea.....

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🚨New Paper Alert: 🔎Progression to MCI & dementia in 3 cohorts: 🧠Tau PET+ ➡️ faster cog decline. 🧠 50% of MCI patients ➡️ dementia in 2.36 years if amyloid+ & high tau at baseline. Led by Lydia Trudel & Joseph Therriault Dr. Pedro Rosa-Neto's lab Read ➡️ bit.ly/46x3Byd

Rates of clinical progression according to biological Alzheimer's disease stages

INTRODUCTION Predicting the rate of cognitive decline and the likelihood of progression to dementia remains a critical unmet need in clinical settings. METHODS We assessed progression to mild cogn...

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Great update on progress in neuroimaging of Alzheimer's disease!

Julie Ottoy@ottoyjulie.bsky.social · 11mo ago

🔥Recent advances in #neuroimaging of #Alzheimers disease 🧠✨ dx.doi.org/10.1002/alz.... ➡️ Valuable resource for both researchers & clinicians! ➡️ ATNIV biomarkers, staging, connectomics & more ➡️ Plus: how are sex & country represented in first/last authorship? @istaart.bsky.social Neuroimaging PIA

We’re excited to welcome our newest Trojans into our Master of Science program at USC! This year they’ll: Train on state-of-the-art MRI Explore computational modeling & big data Collaborate with world-class faculty Build skills to launch careers in neuroscience, medicine & industry✌️🧠

Recent pictures from the Getty Museum gardens, otherwise known as "the good place".

🚨New paper alert! Methods & insights from the Health & Aging Brain Study – Health Disparities (HABS-HD) 🧠📊 We examine amyloid, tau, neurodegeneration, cognition & social determinants of health in Hispanic & NH Black & White older adults. ➡️ bit.ly/4mwp67J @uscini.bsky.social

Health and Aging Brain Study–Health Disparities (HABS‐HD) methods and partner characteristics

INTRODUCTION The Health and Aging Brain Study–Health Disparities (HABS-HD) is an ongoing prospective study aimed at understanding brain health and aging. The current work provides a description of t.....

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This study, led by the talented grad student Boyang Li, identifies microglia undergoing cellular senescence in AD, and targeting cholesterol metabolism in senescent microglia is a therapeutic approach to slow AD progression. onlinelibrary.wiley.com/doi/10.1111/...

Microglial States Are Susceptible to Senescence and Cholesterol Dysregulation in Alzheimer's Disease

Senescent microglia in Alzheimer's disease exhibit dysregulated cholesterol metabolism and express Disease-Associated Microglia (DAM) signatures, including inflammatory and phagocytic markers. Single....

onlinelibrary.wiley.com

The Jagust Lab alumni dinner is one of my favorite parts of AAIC each year - and this year was no exception. What an amazing group of people, brought together by an extraordinary mentor!

🚨Online #AAIC25 diabetes poster by Amaryllis Tsiknia! Can a drink of glucose change functional brain connectivity? 🥮+🧠= 🔎 "Default mode network connectivity responses to glucose ingestion in cognitively unimpaired older adults with and without type 2 diabetes" @uscini.bsky.social

🟣At #AAIC25? Come talk science with Zoe Tsokolas at poster 490 today. 🧠APOE-ɛ4 moderates the association between HDL-c and white matter hyperintensity volume. ⏲️ 3:30 - 4:15 pm @uscini.bsky.social

🎤 Come see Koral Wheeler's talk today at #AAIC25, relating plasma markers of inflammation to longitudinal tau PET in Hispanic, non-Hispanic Black & non-Hispanic White non-demented older adults. 🧠 Session: Developing Topics on Tau Biomarkers 🕝 2:42–2:49 PM | 📍 Room 701 @uscini.bsky.social

At #AAIC25? Come check out Danielle Luu's poster, "Genetic Variants and Brain Tau Levels" today from 3:30-4:15 pm at poster 106. We related genetic variants to PI-2620 tau PET in Hispanic, non-Hispanic Black, and non-Hispanic White older adults 🧠🧬 @uscini.bsky.social

✈️Off to #AAIC25 in Toronto! Excited to share our new research 🧠🧬 • Tau PET & genetic variants • APOE, HDL, & WMH • Longitudinal tau PET & inflammation • DMN & glucose in aging & T2DM See our full presentation lineup ⬇️ 👋Come talk science with us!

"Clocks" that relate amyloid and tau PET to time were used to examine the timing of biomarker changes (including plasma biomarkers) in Alzheimer disease. Plasma Aβ42/40 changes very early! onlinelibrary.wiley.com/doi/10.1002/... #ENDALZ

Timing of Changes in Alzheimer's Disease Plasma Biomarkers as Assessed by Amyloid and Tau PET Clocks

Objective The objective of this study was to evaluate the timing of change of Alzheimer's disease (AD) plasma biomarkers (Aβ42/Aβ40, p-tau217, p-tau181, GFAP, and NfL) from six different assay platf.....

onlinelibrary.wiley.com

🧠New paper alert! We define PI-2620 tau PET cutpoints in a diverse cohort — summary of 🗝️ findings below ⬇️ 675 adults: • AB+ cognitively impaired (CI) • AB– cognitively unimpaired (CU) • 28% Hispanic, 31% NH Black, 41% NH White 🔗 Read it here: (bit.ly/44RLVwe) @victoriatennant.bsky.social