Eran Meshorer
@meshorer.bsky.social
Stem cell epigenetics; chromatin; modeling neurodegenerative diseases; paleo-epigenetics. Hebrew University's Institute of Life Sciences and the Edmond and Lily Safra Center for Brain Sciences (ELSC).
Paper alert! Together with @TevaUSA (Teva), we developed a live imaging system to detect aSYN aggregation, a system suitable for high content screening. Kudos Tzukit Tal and co-authors!👇🔥 link.springer.com/article/10.1...
A Live-Cell Imaging System for the Identification of Pro- and Anti-Aggregatory α-Synuclein Modulators - Molecular Neurobiology
α-Synuclein (αSyn) aggregation is a defining pathological feature of synucleinopathies, including Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy (MSA). However, existing i...
link.springer.com
Berlin Marathon, DKFZ visit, then EMBO Members’ meeting. What a exciting week!
EMBO@embo.org · 4w agoOur Fellows' Meeting opens today! 🧪 A warm welcome to all EMBO Fellows joining us in Heidelberg. We're excited for the days ahead, and next week our EMBO Members join us for the joint meeting. Follow along for highlights! #EMBOFMM26
Check out this fantastic work, which we were happy to contribute to, by the amazing Gokhman and Inoue labs and colleagues. Congrats David and all involved! 🔥🔥🔥
David Gokhman@david-gokhman.bsky.social · last mo.Humans are remarkably prone to degenerative skeletal diseases. Other apes, much less so, even in old age. In our new paper in @nature.com , we map the genetic changes that shaped our skeleton and uncover a major clue to why it is so vulnerable to degeneration.🧵👇 www.nature.com/articles/s41...
The final program of the MIND-IL conference "Developmental Biology, Stem Cells & Regeneration", Oct-26 at the Weizmann Institute is now available! Check it out👇🔥🔥 Registration is still open. Join us!
Super interesting paper. Congrats Karsten and team!
Karsten Rippe@karsten-rippe.bsky.social · 2mo ago🧬 1/ HP1α marks silenced heterochromatin, but how does it repress, and what happens when transcription is switched on? On mouse fibroblast chromocenters, HP1α stays bound, its barrier is local, and the domain reorganizes nanodomain by nanodomain. 👉 @cp-molcell.bsky.social doi.org/10.1016/j.mo...
links.springernature.com/f/a/3jNqJ4R4...
Client Challenge
links.springernature.com
Eran Meshorer@meshorer.bsky.social · 2mo agoHot from the oven!🔥🔥 Excited to share Tamar Segal's PhD work in @GenomeBiology, where we developed a pipeline to identify regulators of transcriptional noise in embryonic stem cells, revealing NAP1L1 as a stabilizer! Congrats Tamar and authors! rdcu.be/Q1ucQSYdgvta
Hot from the oven!🔥🔥 Excited to share Tamar Segal's PhD work in @GenomeBiology, where we developed a pipeline to identify regulators of transcriptional noise in embryonic stem cells, revealing NAP1L1 as a stabilizer! Congrats Tamar and authors! rdcu.be/Q1ucQSYdgvta
Join us for the Mind-IL conference on Developmental Biology, Stem Cells, and Regeneration to take place on Monday, Oct-26 at the Weizmann Institute. Slots are available for short talks, and registration is free for students!
Our lab took part in a joint course on scientific illustrations between ELSC and Bezalel. The students (Aderet, Nika, Anja, Snir & Alice) were amazing! Now our wall is decorated with their creativity (Plus Walaa’s farewell present sign & Special Tnxxx to Avital!)
Exciting science coming up👇🔥👇
SMART Symposia@smartsymposium.bsky.social · 5mo agoAnnouncing SMART Genome Symposium: From Structure to Function ! 📅 October 14–16, 2026 Focus: 3D genome organization | Chromatin dynamics | Computational modeling Register now symposia.smart.org.cn/sym/event/Fu... #SMARTSymposia #SMARTshenzhen #Genome #Genomes #Biophysics
This new method, BLISS, to detect single molecule fluorescent bursts revealed the “hyperdynamic” fraction of HP1a we previously observed in pluripotent stem cells. Check it out👇🔬🔥
LernerLab@lernerlab.bsky.social · 6mo agowww.biorxiv.org/content/10.6... Single-molecule fluorescence bursts of FP-tagged proteins are achieved in live cells using a new method, BLISS, exposing a rare subpopulation of heterochromatin protein 1alpha dense clusters in undifferentiated embryonic stem cells.
Check out this new Review Article in TiG by the amazing Elad Dvir, a joint student of the Shifman and Meshorer labs👇👇
Sagiv Shifman@sagivshifman.bsky.social · 6mo agoWhy do pathogenic variants in the same gene lead to different neurodevelopmental outcomes? Our Trends in Genetics review discusses how variant effects, genetic background, environment, and developmental noise may all contribute. www.cell.com/trends/genet... authors.elsevier.com/a/1mxFv_3rsx...
Beautiful work
Kazuhiro Maeshima@kazu-maeshima.bsky.social · 7mo agoOur H1 paper is out #ScienceAdvances: www.science.org/doi/10.1126/... @masaashimazoe.bsky.social et al. reveal that linker histone H1 acts as a liquid-like glue to organize chromatin in live cells. 🎉 Fantastic collab with @rcollepardo.bsky.social @janhuemar.bsky.social and others—huge thanks! 🙌 1/
Are PolyQ Inclusion Bodies detrimental or protective in Huntington’s Disease? The amazing Walaa Oweis in my lab shows they are protective in human iPSC-derived neurons, confirming Finkbeiner’s observation in rodents. She further found that ATF3 is required for their formation. 🔥🔥🔥 rdcu.be/fbjil
ATF3-dependent formation of inclusion bodies in polyQ-expressing human iPSC-derived neurons confers cellular protection - Cell Death & Differentiation
Cell Death & Differentiation - ATF3-dependent formation of inclusion bodies in polyQ-expressing human iPSC-derived neurons confers cellular protection
nature.com
Functional fertile sperm from mouse embryonic stem cells👇🔥
Science News@scinews.bsky.social · 8mo agoReconstitution of sex determination and the testicular niche using mouse pluripotent stem cells. @science.org "In vitro gametogenesis could be beneficial in various settings ranging from human reproduction to helping with recovery of endangered species." www.science.org/doi/10.1126/...
And today Shalhevet’s Flashtalk about SCA3 concluded our lab’s presentations. Kudos everyone!⚡️🧬🔬
Eran Meshorer@meshorer.bsky.social · 8mo ago🔥Flashtalks and posters in ILANIT FISEB meeting today by Shira Siegel, Shira Horev, Riki Masar, Eden Mishne and Avital Pushett🔥
🔥Flashtalks and posters in ILANIT FISEB meeting today by Shira Siegel, Shira Horev, Riki Masar, Eden Mishne and Avital Pushett🔥
Extracellular environment stabilization of stem cell state identity via KDM3A👇🔥
Carmelo Ferrai@carmeloferrai.bsky.social · 8mo agoTread -1- EpiSci - I am very proud to share with you our new study that you can access on @biorxivpreprint.bsky.social (see link below) "The Interaction with Nanotopographical Environment regulates nuclear mechanoresponse in mESCs via Histone Demethylase KDM3A. www.biorxiv.org/content/10.6...
Finally out! Patrick developed a system to study SET isoform specificity in ES cells, revealing a role for SETa/b switch in endoderm specification. Check it out🔥 academic.oup.com/nar/article/...
Distinct roles for SETα and SETβ in early cell fate decisions
Abstract. SET, the nuclear proto-oncogene, is primarily expressed as SETα in embryonic stem cells (ESCs). Upon pluripotency exit, a transcriptional switch
academic.oup.com
A super interesting study!👇👇👇🔥
Sagiv Shifman@sagivshifman.bsky.social · 10mo ago1/6 Thrilled to share our new paper in Nature Neuroscience with an amazing team of collaborators: CRISPR knockout screens map essential genes/pathways for neuronal differentiation and implicate PEDS1 in neurodevelopment. www.nature.com/articles/s41...
👇👇👇
Bruno Di Stefano@distefanolab.bsky.social · 12mo ago1/ Excited to share our new study with @brumbaugh-lab.bsky.social, out in @natbiotech.nature.com! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵 www.nature.com/articles/s41...
Such a big loss. What an inspiration he was for so many of us
Mark Dawson@mafdawson.bsky.social · last yr.Science has lost a GIANT and the world has lost one of the kindest most inspiring people I had the pleasure of knowing. Just an extraordinary man whose curiosity was infectious and whose dry wit will always be memorable- RIP John www.cam.ac.uk/research/new...
The incidence of ASD in Israel is slightly higher than the rest of the world. There's no Tylenol in Israel.
Chise@sailorrooscout.bsky.social · last yr.Just a reminder before the “big announcement” today. Autism was discovered in 1911 and the modern definition of Autism came in 1943. Tylenol wasn’t widely used until the 1950s. Anyone trying to tell you that Tylenol causes Autism isn’t someone that should be taken seriously.
Thank you EMBO and EMBO members! Excited to join!
EMBO@embo.org · last yr.Welcome and congratulations to the 60 new members and 9 associate members who have been elected to the EMBO Membership! This honour celebrates #research excellence and outstanding achievements in the #LifeSciences. 🧪 Learn more here: www.embo.org/press-releas... #EMBOMembers2025
🔬✨ Excited to share a major milestone from my PhD research at Institut Curie, where I am a first author in a recently published paper in Nature Communications! www.nature.com/articles/s41...
H3.3 deposition counteracts the replication-dependent enrichment of H3.1 at chromocenters in embryonic stem cells - Nature Communications
In mammals, two major non-centromeric histone H3 (H3.1/2 and H3.3) variants, display distinct nuclear distribution patterns across the genome and use distinct deposition pathways. Here the authors rev...
nature.com
We are looking to take on an intern at EMBL Rome, for anyone interested in CRISPR and Epigenetics training. The traineeship is 3-12-months, in Rome (Italy), should start by July, and is supervised by the outstanding @steliostsagkris.bsky.social. #job #internship; see info below...
I am raising funds for a unique center dedicated to AIDS-impacted youth, and will run the NY marathon on their behalf. Feel free to contribute!🙂🙏🏃♂️➡️ fundraisers.nyrr.org/eran-meshorer
New York City Marathon
Zara's Center is an after-school safe haven for AIDS orphans and vulnerable children in Bulawayo, Zimbabwe. The Center provides daily meals, academic enrichment, medical care, work training, recreatio...
fundraisers.nyrr.org