Colleagues, Since the launch of The Journal of Precision Medicine: Health and Disease, papers are flowing in and we're ready to expand the editorial board! Nominate a colleague or self-nominate! An exciting opportunity to shape precision medicine, get editorial experience and host special issues!

The Journal of Precision Medicine: Health and Disease@jprecmed.bsky.social · last wk.

Join our Editorial Board! 🎓️ We’re inviting nominations for new Editorial Board members to help shape the future of precision medicine. Self-nominations are warmly welcomed. Submit a statement of interest, CV and short biography to jpm@physoc.org by 30 November 2026.

🎓️ EDITOR'S CHOICE🎓️ Christoph Sandmann from @uniheidelberg.bsky.social and colleagues reveal how the endoplasmic reticulum (ER) and sarcoplasmic reticulum (SR) evolve during heart muscle development. Read the study👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

#Research by Miguel Martin-Aragon Baudel of @pharmacologyucc.bsky.social and colleagues investigates CaV1.2 dynamics in native male arterial myocytes 🫀 🔬 Read the study here👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

Looking for a home for your Physiolgy preprint? We welcome research that reveals the mechanisms driving physiological processes across all levels of organisation See what we publish... buff.ly/rytcQXb ...or learn how we're championing preprints: buff.ly/55KVQ8P

Thrilled to be co-organizing the 2027 FASEB Science Research Conference on Vasoregulation: Signaling & Multicellular Inputs, with Scott Earley and Madeline Nieves-Cintrón. Save the date for Washington DC, Aug 29–Sep 1. Registration details to follow very soon. Please circulate widely!

This study shows a fundamental methodological advance enabling measurements of single-channel gating behavior of CRAC channels whose unitary currents are too small to be resolved electrically. The work is convincing and findings have biological relevance.

Optical single-channel recording of CRAC channels with HaloTag and a Ca2+-sensitive ligand

Altmetric provides a collated score for online attention across various platforms and media.See more details

buff.ly

Very happy to share our latest work out in PNAS this week, led by Amy Xiang. We show that capillary thin-strand pericytes express TMEM16A calcium-activated chloride channels, which set the operating point for capillary control of cerebral blood flow in vivo. www.pnas.org/doi/10.1073/...

Tomorrow! June 4—Kafui Dzirasa, MD, PhD from Duke University Medical Center will be our distinguished speaker at the 2026 Carlson Lecture.🎙️🧠 Join us at 12pm in the Genome Auditorium, room 1005. Description: Portrait photo of the lecture speaker

Join us for the 2026 Carlson Lecture, with speaker Kafui Dzirasa, MD, PhD from Duke U. Medical Center. Learn how engineered neural circuits may restore healthy brain function and help prevent psychiatric disorders. Thursday, June 4th, 12pm, Genome Auditorium Description: Photo, scientist smiling

In this #TopicalReview, Nathan Grainger of @unevadareno.bsky.social discusses the role of resident #pacemaker cells in the #renal pelvis and argues that a greater understanding of pacemaker and peristaltic mechanisms is warranted 🔬 🔎 Read it here: 📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...

Happy Monday everyone!!! Happy to share this book chapter by my awesome partner Made Nieves-Cintron and #MnMLab members on "Experimental Models for Studying Cardiovascular Dysfunction in Metabolic Syndrome" Highly relevant topic these days!!! link.springer.com/chapter/10.1...

Experimental Models for Studying Cardiovascular Dysfunction in Metabolic Syndrome

Metabolic syndrome (MetS) encompasses an interconnected set of risk factors, including abdominal obesity, insulin resistance, hypertension, dyslipidemia, and systemic inflammation, all of which signif...

link.springer.com

Our May issue is here! rupress.org/jgp/issue/15... The cover represents beat-locked mitochondrial ATP consumption in a sinoatrial node pacemaker myocyte. From Muñoz, @lfsantana68.bsky.social and colleagues: doi.org/10.1085/jgp....

🚨Not all channels are created equal🚨 New work from our lab shows that PKA regulates vascular CaV1.2 via S1928 — NOT Rad — phosphorylation, overturning the assumption that cardiac and vascular channels are regulated the same way. www.ahajournals.org/doi/10.1161/...

Context-Dependent Control: PKA Regulation of Vascular CaV1.2 Requires S1928 not Rad Phosphorylation | Arteriosclerosis, Thrombosis, and Vascular Biology

ahajournals.org

Our new paper is out! 🎉 Let-7 doesn’t act through a single pathway: it controls neocortical neuron fate and migration via distinct downstream mechanisms, with RBX2 dedicated to migration. A new layer of post-transcriptional control shaping cortical development www.pnas.org/doi/10.1073/...

Compelling new study by @maartjewesthoff.bsky.social, Taylor Voelker, @roseedixon.bsky.social et al. This latest work in Circulation Research explores what happens when angiotensin II signaling becomes chronic. www.ahajournals.org/doi/10.1161/...

Phosphoinositide Depletion and Compensatory Phospho-Signaling in Angiotensin II-Induced Heart Disease: Protection Through PTEN Inhibition | Circulation Research

BACKGROUND: Contractile dysfunction, hypertrophy, and cell death during heart failure are linked to altered Ca2+ handling and elevated levels of the hormone AngII (angiotensin II), which signals throu...

ahajournals.org

Beat-locked ATP microdomains in the sinoatrial node map a Ca2+-timed energetic hierarchy and regional pacemaker roles. New study from Manuel F. Muñoz, Fernando Santana @lfsantana68.bsky.social and colleagues @ucd-physiology.bsky.social rupress.org/jgp/article/... #IonChannels #CardiacMuscle

Muñoz, @lfsantana68.bsky.social et al. show that beat-locked cytosolic and mitochondrial ATP transients in sinoatrial node myocytes sort into high-gain, low-gain, or consumption-dominant modes aligned with superior–inferior vascular–mitochondrial gradients. rupress.org/jgp/article/... #CardiacMuscle

A new #PMB paper @JPhysiol reveals beat-to-beat ATP dynamics. Imaging shows mitochondrial ATP waves synchronized with contraction and distinct energetic strategies in male vs. female heart cells. Congratulations Paula Rhana, Collin Matsumoto, @lfsantana68.bsky.social

Demonstration of beat‐to‐beat, on‐demand ATP synthesis in ventricular myocytes reveals sex‐specific mitochondrial and cytosolic dynamics

Abstract figure legend Beat-locked mitochondrial ATP transients reveal modular, sex-specific bioenergetic control during excitation–contraction coupling. A, each action potential activates L-type CaV...

physoc.onlinelibrary.wiley.com

#CallForPapers ⏰️ Don't miss the March 15th deadline! Submit your research on topics including #IonChannel structure and biophysical properties, regulatory mechanisms, pharmacology, physiological functions, disease relevance, and drug discovery 👉 rupress.org/JGP/pages/ca...

Commentary: Schmidt and Kopec @mpi-nat.bsky.social discuss how Lopez-Mateos et al. @vyy-sf.bsky.social (rupress.org/jgp/article/...) used AlphaFold 2 to generate structural ensembles of voltage-gated sodium channels across different conformations. rupress.org/jgp/article/... #IonChannels

I had a great time talking about the importance of storytelling our science at the @biophysicalsoc.bsky.social President’s Symposium today! Always extra fun with my little fan club tags along 🩷

Apply by Feb 23—Junior Specialist position in #PMB’s Belford Lab

Daniah Beleford@daniahbeleford.bsky.social · 7mo ago

My lab at the University of California, Davis is hiring a Junior Specialist! Apply by February 23. JPF07490: Junior Specialist: Vascular Biology – Beleford Lab For more information and to apply: recruit.ucdavis.edu/JPF07490

After 50 years in science, former #HHMIInvestigator David Clapham’s advice is simple: “You have to see problem-solving as fun.” From training with Nobel laureates to deepening our understanding of ion channels & leading at HHMI, he retires with a lasting legacy: hhmi.news/3O3kYji.

A lifelong passion for writing helped rising star @doctheagrif.bsky.social land a book deal and publish 15 chapter books for early readers, covering topics ranging from what the cerebellum does to how a cake bakes. By @avaskham.bsky.social www.thetransmitter.org/craft-and-ca...

Crafting tales of science with Theanne Griffith

A lifelong passion for writing helped the neuroscientist land a book deal and publish 15 chapter books for early readers, covering topics ranging from what the cerebellum does to how a cake bakes.

thetransmitter.org

Excited to be speaking at this year’s Biophysical Society Presidential Symposium on the importance of communicating science to the public 👩🏾‍🔬🧫🧬🔬🥼🧪👩🏾‍🔬

Biophysical Society@biophysicalsoc.bsky.social · 7mo ago

The President’s Symposium at #bps2026 serves to empower biophysicists to tell stories that build public confidence in science. Speakers will discuss perspectives on the crisis in US investment in science, and approaches for conveying the value of research to human health and prosperity

Excitability isn't intrinsic to ion channels alone; it's an emergent property of the CMIC Axis. @vesselman.bsky.social & I link Capillaries, Mitochondria & Channels to function. Break the link, lose the function. doi.org/10.1113/JP28... @jphysiol.bsky.social

Sudha (@chakrapanilab.bsky.social) and Julio (@cvlab.bsky.social) are organizing the 2026 Ion Channel Gordon Research Conference: Ion Channels Across Scales — Bridging Molecular Events to Physiological Outcomes, to be held at Mount Holyoke College, July 12–17, 2026. 1/3

We're incredibly excited to announce that Dr. Theanne Griffith @doctheagrif.bsky.social of #PMB Griffith Lab has been promoted to Associate Professor with tenure, effective July 1, 2026! Congratulations, Theanne, on this well-earned achievement! 🎉🌟 Her lab research: www.thegriffithresearchgroup.com

Congrats to my colleague Dr. Theanne Griffith @doctheagrif.bsky.social for receiving a 2025 Rising Star of Neuroscience award! ⭐️ 🧠 ⭐️ www.thetransmitter.org/early-career...

The Transmitter’s Rising Stars of Neuroscience 2025

We recognize the outstanding achievements of 25 neuroscientists who stand to shape the field for years to come.

thetransmitter.org

🚨 We are recruiting postdocs! If you're interested in reproductive, stem cell/developmental biology, and/or women's health, please apply! 📝 Please repost! 🚩 More info here: hhmi.wd1.myworkdayjobs.com/en-US/Extern...

Postdoctoral Scientist - Zhang Lab

Primary Work Address: One Shields Avenue, Davis, CA, 95616 Current HHMI Employees, click here to apply via your Workday account. The Howard Hughes Medical Institute (HHMI) advances the discovery and s...

hhmi.wd1.myworkdayjobs.com